Zizyphus jujuba var. spinosa

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Other Names:

Historical Use of Zizyphus jujuba var. spinosa

Zizyphus jujuba var. spinosa in Traditional Chinese Medicine


Chaozaoren ³´ÔæÈÊ Chinese Name (pinyin): Suanzaoren

Chinese Name  :

Common Name  :Wild or Spiny Jujuba Seed

Specific Name  : Semen ziziphi spinosae

Scientific Name:
Collection  : The ripe fruit is collected in later autumn and early winter. The seed collected and removed from the pulp and shell (endocarp) and dried in the sun.

Description  : Oblate or flattened ellipsoidal, 5 - 9 mm long, 5 - 7 mm wide, about 3 mm thick. External purplish-red or purplish brown, smooth, lustrous some fissured. One surface even with 1 raised longitudinal line in the center. The other surface slightly raised. One end dented, showing a linear hilum, the other end having finely raised chalaza. Testa fragile, endosperm white, cotyledons 2, pale yellow, oily, odor slight taste weak.

Identification  : (1)Powder: Brownish red, palisade cells of testa brownish red, polygonal in surface view, about 15 µm in diameter with thickened and lignified walls and small lumen. Cells of tegmen brownish yellow, rectangular or sub-square with beaded and lignified walls in surface view. Epidermal cells of cotyledon containing fine clusters of prism of calcium oxalate.(2)To 1g of the powder add 30 ml of methanol, heat under reflux for 1 hour and filter. Evaporate the filtrate to dryness, dissolve the residue in 0.5 ml of methanol used as the test solution. Dissolve jujuboside ACRS and jujuboside B CRS in methanol to produce a mixture containing 1 mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and n-butanol saturated with water as the mobile phase. Apply separately to the plate 10µl of each of the two solutions. After developing and removal of the plate, dry it in the air. Spray with 1% solution of vanillin in sulfuric acid and examine immediately. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.Foreign matter: Not more than 5% (Appendix 1X A)

Processing  : Remove the remained shells. Break to pieces before use.Stir fried: stir fry the as described under the method for simple stir frying (Appendix 11 D) to inflated and the color slightly darken. Break to pieces before use.

Action  : To replenish the liver, to cause tranquilizations, to arrest excessive perspiration, and to promote the production of body fluid.

Indication  : insomnia, dream-disturbed sleep; excessive sweating due to debility; thirst due to consumption of body fluid

Precautions  : .

Dosage  : 9 to 15 g.

Storage  : Preserve in a cool and cry place, protected from moth.

Synonymns for Zizyphus jujuba var. spinosa

Patent Medicines and Medicines with Multiple Ingredients that include Zizyphus jujuba var. spinosa

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Zizyphus jujuba var. spinosa in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Chae Bin Lee, Jee Sun Min, Soon Uk Chae, Hye Min Kim, Jun Hee Jang, In Ho Jung, Yu Fen Zheng, Jong Hoon Ryu, Soo Kyung Bae
Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
J Pharm Biomed Anal: 2020, 178;112919
[PubMed:31654856] [WorldCat.org] [DOI] (I p)

Jian Gao, Qiming Wang, Yuwei Huang, Kailin Tang, Xue Yang, Zhiwei Cao
Front Pharmacol: 2019, 10;925
[PubMed:31507421] [WorldCat.org] [DOI] (P e)

Tingting Yang, Leilei Fang, Tingting Lin, Jiayi Li, Yanqing Zhang, Aimin Zhou, Junbo Xie
Ultrasonicated sour Jujube seed flavonoids extract exerts ameliorative antioxidant capacity and reduces Aβ-induced toxicity in Caenorhabditis elegans.
J Ethnopharmacol: 2019, 239;111886
[PubMed:31026552] [WorldCat.org] [DOI] (I p)

Xiaoxi Zhang, Wenxing Zhou, Hui Liu, Erlei Bai, Jizhou Zhang, Zengwen Liu
Dynamics of the remediating effects of plant litter on the biological and chemical properties of petroleum-contaminated soil.
Environ Sci Pollut Res Int: 2019, 26(13);12765-12775
[PubMed:30877549] [WorldCat.org] [DOI] (I p)

Zehai Hou, Cong Wei
De novo comparative transcriptome analysis of a rare cicada, with identification of candidate genes related to adaptation to a novel host plant and drier habitats.
BMC Genomics: 2019, 20(1);182
[PubMed:30845906] [WorldCat.org] [DOI] (I e)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects