Vitex negundo var. cannabifolia
Contents
Nomenclature
Other Names:
Historical Use of Vitex negundo var. cannabifolia
Vitex negundo var. cannabifolia in Traditional Chinese Medicine
Background
Chinese Name (pinyin): Mujingye
Chinese Name :
Common Name :Hempleaf Negundo Chastetree leaf
Specific Name : Folium viticis negundo
Scientific Name:
Collection : The drug is collected when foliage growing luxuriantly in summer and autumn, removed from stem and branch.
Description : leaves digitately compound, leaflets 5 or 3, lanceolate or elliptical lanceolate, the middle leaflets 5 - 10cm long, 2 - 4cm wide, the lateral leaflets relatively small, apex acuminate, base cuneate, margin dentate, upper surface green, lower surface pale green, both surface pubescent along veins, relatively dense on the lower surface of young leaf, petioles 2 - 6cm long, with shallow groove, densely covered with greyish white hairs, odor aromatic, taste pungent and slightly bitter.
Identification : Transverse section: upper epidermal cells arranged regularly, pubescent on both surfaces and more prominent on the lower surface. Palisade tissue of 3 - 4 rows of cells, spongy tissue loose. Vasculat bundles of the midrib collateral, U shaped with 1 - 5 small vascular bundles in the hallow of U shaped part, pits visible on the surrounding parenchymatous cells, several rows of collenchymatous cells occurring inside the upper epidermis and lower epidermis.Leaf in surface view: Upper epidermal cells subpolygonal or irregular with sinuous anticlinal walls. Non-glandular hairs, 1 - 4 celled, apical cells elongated with warty prominences. Glandular scales with a 4 celled head upt to 55µm in diameter and unicellular stalk, small glandular hairs few with a 1 - 4 celled head up to 25µm in diameter and a 1 - 3 celled stalk, very short. Lower epidermal cells relatively small, 17 - 30 (-45) µm long, 12 - 25µm in diameter with slightly sinuous or straight anticlinal walls, stomata subrounded, anomaytic, 15 - 20µm in diameter with 3 - 6 subsidiary cells. Non-glandular hairs, glandular scales and small glandular hairs numerous.
Processing :
Action : To counteract toxicity, and to induce expectoration, relieve cough and asthma.
Indication : chronic bronchitis with cough and asthma
Precautions :
Dosage : Used while fresh for the extraction of Oleum Viticis Negundo.
Storage : Preserve in a cool place.
Nomenclature
Other Names:
Historical Use of Vitex negundo var. cannabifolia
Vitex negundo var. cannabifolia in Traditional Chinese Medicine
Background
Chinese Name (pinyin): Mujingyou
Chinese Name :
Common Name :Negundo Chastetree Oil
Specific Name : Oleum viticis negundo
Scientific Name:
Collection :
Description : A pale yellow to orange yellow, clear liquid, odour charateristic and aromatic, taste slightly pungent. Freely miscible with hydrated ethaol, chloroform or ether, practically insoluble in water.Relative density: 0.890 - 0.910 at 25ºC (Appendix Vll A)Refractive index: 1.485 - 1.500 (Appendix Vll F)
Identification : 1.Dissolve about 0.1g of sodium nitrite in 1 - 2 drops of water. Add 0.3ml of the oil and 0.5ml of dilute sulfuric acid, mix well, the oil layer shows a jade green colour.2.To 1 drop of the oil add 1ml of chloroform, mix well, add 5% solution of bromine in chloroform in dropwise, then the bromine colour of the solution disappears, continue to add 5% solution of bromine in chloroform in dropwise until the solution becomes pale yellow, a green colour is produced gradually on standing.Fatty oil: To 1ml of the oil add 10ml of ethanol, oil globules should not be produced on standing.
Processing :
Action : To promote expectoration, and to relieve cough and asthma.
Indication : chronic bronchitis
Precautions :
Dosage : 20 to 40 mg, 3 times a day.
Storage : Preserve in tightly closed containers, stored in a cool place, and protected from light.
Synonymns for Vitex negundo var. cannabifolia
Patent Medicines and Medicines with Multiple Ingredients that include Vitex negundo var. cannabifolia
Pharmaceutical Information
Chemical Constituents
Evidence or the Use of Vitex negundo var. cannabifolia in the Treatment of Epilepesy
Basic Science
Animal Studies
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
Meta-Analysis
1st Five Results: pubmed search
Jing Sun, Manman Li, Yongru Wang, Chuang Chang, Yujie Pei, Kewu Zeng, Yunfang Zhao, Jiao Zheng, Yuelin Song, Pengfei Tu, Huixia Huo, Jun Li
Phenolic Glucosides from the Leaves of Vitex negundo var. cannabifolia.
Chem Biodivers: 2022, 19(11);e202200652
[PubMed:36129755]
[WorldCat.org]
[DOI]
(I p)
Pingping Dong, Lei Shi, Shaoping Wang, Shan Jiang, Haoran Li, Fan Dong, Jing Xu, Long Dai, Jiayu Zhang
Rapid Profiling and Identification of Vitexin Metabolites in Rat Urine, Plasma and Faeces after Oral Administration Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer Coupled with Multiple Data-mining Methods.
Curr Drug Metab: 2021, 22(3);185-197
[PubMed:33397253]
[WorldCat.org]
[DOI]
(I p)
Wei Zhang, Jia-Lun Wang, Li-Ying Tang, Zhi-Lai Zhan, Hua-Sheng Peng, Hong-Jun Yang
[Herbal textual research on Chinese medicine "Manjingzi"(Viticis Fructus)].
Zhongguo Zhong Yao Za Zhi: 2019, 44(24);5503-5507
[PubMed:32237401]
[WorldCat.org]
[DOI]
(P p)
Yueting Li, Jing Sun, Huixia Huo, Yao Liu, Wenjing Liu, Qian Zhang, Yunfang Zhao, Yuelin Song, Jun Li
Definitely simultaneous determination of three lignans in rat using ultra-high performance liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci: 2018, 1100-1101;17-26
[PubMed:30268953]
[WorldCat.org]
[DOI]
(I p)
Yue-Ting Li, Dao-Ran Pang, Zhi-Xiang Zhu, Hui-Xia Huo, Yi Ren, Zhi-Tian Peng, Jiao Zheng, Yun-Fang Zhao, Peng-Fei Tu, Jun Li
[Chemical constituents from the fruits of Vitex negundo var. cannabifolia and their biological activities in vitro].
Zhongguo Zhong Yao Za Zhi: 2016, 41(22);4197-4203
[PubMed:28933089]
[WorldCat.org]
[DOI]
(P p)
