Vitex negundo var. cannabifolia

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Nomenclature

Other Names:

Historical Use of Vitex negundo var. cannabifolia

Vitex negundo var. cannabifolia in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Mujingye

Chinese Name  :

Common Name  :Hempleaf Negundo Chastetree leaf

Specific Name  : Folium viticis negundo

Scientific Name:
Collection  : The drug is collected when foliage growing luxuriantly in summer and autumn, removed from stem and branch.

Description  : leaves digitately compound, leaflets 5 or 3, lanceolate or elliptical lanceolate, the middle leaflets 5 - 10cm long, 2 - 4cm wide, the lateral leaflets relatively small, apex acuminate, base cuneate, margin dentate, upper surface green, lower surface pale green, both surface pubescent along veins, relatively dense on the lower surface of young leaf, petioles 2 - 6cm long, with shallow groove, densely covered with greyish white hairs, odor aromatic, taste pungent and slightly bitter.

Identification  : Transverse section: upper epidermal cells arranged regularly, pubescent on both surfaces and more prominent on the lower surface. Palisade tissue of 3 - 4 rows of cells, spongy tissue loose. Vasculat bundles of the midrib collateral, U shaped with 1 - 5 small vascular bundles in the hallow of U shaped part, pits visible on the surrounding parenchymatous cells, several rows of collenchymatous cells occurring inside the upper epidermis and lower epidermis.Leaf in surface view: Upper epidermal cells subpolygonal or irregular with sinuous anticlinal walls. Non-glandular hairs, 1 - 4 celled, apical cells elongated with warty prominences. Glandular scales with a 4 celled head upt to 55µm in diameter and unicellular stalk, small glandular hairs few with a 1 - 4 celled head up to 25µm in diameter and a 1 - 3 celled stalk, very short. Lower epidermal cells relatively small, 17 - 30 (-45) µm long, 12 - 25µm in diameter with slightly sinuous or straight anticlinal walls, stomata subrounded, anomaytic, 15 - 20µm in diameter with 3 - 6 subsidiary cells. Non-glandular hairs, glandular scales and small glandular hairs numerous.

Processing  :

Action  : To counteract toxicity, and to induce expectoration, relieve cough and asthma.

Indication  : chronic bronchitis with cough and asthma

Precautions  :

Dosage  : Used while fresh for the extraction of Oleum Viticis Negundo.

Storage  : Preserve in a cool place.

Nomenclature

Other Names:

Historical Use of Vitex negundo var. cannabifolia

Vitex negundo var. cannabifolia in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Mujingyou

Chinese Name  :

Common Name  :Negundo Chastetree Oil

Specific Name  : Oleum viticis negundo

Scientific Name:
Collection  :

Description  : A pale yellow to orange yellow, clear liquid, odour charateristic and aromatic, taste slightly pungent. Freely miscible with hydrated ethaol, chloroform or ether, practically insoluble in water.Relative density: 0.890 - 0.910 at 25ºC (Appendix Vll A)Refractive index: 1.485 - 1.500 (Appendix Vll F)

Identification  : 1.Dissolve about 0.1g of sodium nitrite in 1 - 2 drops of water. Add 0.3ml of the oil and 0.5ml of dilute sulfuric acid, mix well, the oil layer shows a jade green colour.2.To 1 drop of the oil add 1ml of chloroform, mix well, add 5% solution of bromine in chloroform in dropwise, then the bromine colour of the solution disappears, continue to add 5% solution of bromine in chloroform in dropwise until the solution becomes pale yellow, a green colour is produced gradually on standing.Fatty oil: To 1ml of the oil add 10ml of ethanol, oil globules should not be produced on standing.

Processing  :

Action  : To promote expectoration, and to relieve cough and asthma.

Indication  : chronic bronchitis

Precautions  :

Dosage  : 20 to 40 mg, 3 times a day.

Storage  : Preserve in tightly closed containers, stored in a cool place, and protected from light.

Synonymns for Vitex negundo var. cannabifolia

Patent Medicines and Medicines with Multiple Ingredients that include Vitex negundo var. cannabifolia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Vitex negundo var. cannabifolia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Yueting Li, Jing Sun, Huixia Huo, Yao Liu, Wenjing Liu, Qian Zhang, Yunfang Zhao, Yuelin Song, Jun Li
Definitely simultaneous determination of three lignans in rat using ultra-high performance liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.: 2018, 1100-1101;17-26
[PubMed:30268953] [WorldCat.org] [DOI] (I p)

Yue-Ting Li, Dao-Ran Pang, Zhi-Xiang Zhu, Hui-Xia Huo, Yi Ren, Zhi-Tian Peng, Jiao Zheng, Yun-Fang Zhao, Peng-Fei Tu, Jun Li
[Chemical constituents from the fruits of Vitex negundo var. cannabifolia and their biological activities in vitro].
Zhongguo Zhong Yao Za Zhi: 2016, 41(22);4197-4203
[PubMed:28933089] [WorldCat.org] [DOI] (P p)

Yue-Ting Li, Man-Man Li, Jing Sun, Zhi-Xiang Zhu, Yue-Lin Song, Dao-Ran Pang, Jiao Zheng, Yun-Fang Zhao, Peng-Fei Tu, Jun Li
Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia.
Nat. Prod. Res.: 2017, 31(8);918-924
[PubMed:27830592] [WorldCat.org] [DOI] (I p)

Dong Xin Wen, Ning Yang, Man Yuan Yang
[Effects of re-vegetation on soil microbial functional diversity in purple soils at different re-vegetation stages on sloping-land in Hengyang, Hunan Province, China.] [衡阳紫色土丘陵坡地植被恢复对土壤微生物功能多样性的影响.]
Ying Yong Sheng Tai Xue Bao: 2016, 27(8);2645-2654
[PubMed:29733154] [WorldCat.org] [DOI] (P p)

Sheng-Tao Fang, Na-Na Kong, Bing-Fei Yan, Cui-Yun Yang, Jian-Hua Wang, Su-Jing Liu, Hai-Zhu Jin, Chuan-Hai Xia
Chemical constituents and their bioactivities from the fruits of Vitex negundo var. cannabifolia.
Nat. Prod. Res.: 2016, 30(24);2856-2860
[PubMed:27093612] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects