Sinomenium acutum

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Nomenclature

Other Names:

Historical Use of Sinomenium acutum

Sinomenium acutum in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Qingfengteng

Chinese Name  :

Common Name  :Orientvine Stem

Specific Name  : Caulis sinomenii

Scientific Name:
Collection  : The drug is collected in late autumn and early winter, tied up in bundle or cut into long section, and dried in the sun.

Description  : Oblong - cylindrical, usually somewhat curved, 20 - 70 cm long or more, 0.5 - 2 cm in diameter. Externally greenish-brown to brown, some greyish - brown, with fine longitudinal striations and lenticels. Nodes slightly swollen and brached. Texture light, hard and fragile, easily broken, fracture uneven, greyish-yellow or pale greyish-brown, bark narrow, wood rays arranged radially, pith pale yellowish-white or yellowish-brown. Odour, slight; taste, bitter.

Identification  : 1. Transverse section: Epidermal cells 1 layer, covered with thick cuticle. Some prossessing cork cells. Cortex scattered with fibers and stone cells. Pericyclic fibre groups in crescent shape, the inner side of fibre groups usually prossessing 2-5 rows of stone cells, tangetially elongated and linked with stone cell groups of rays to a ring. Vascular bundles collateral. Phloem rays gradullary widened outwards, conical or branching stone cells visible; phloem, cells mostly collapsed, sometimes scattered with 1-3 fibres in the outer side and serveral layers of parenchymatous cells in the inner side. Xylem vessels singly scattered or serveral linked up tangentially. The walls of cells surrounding pith relatively thickened, distinctly pitted. Parenchymatous cells containing starch granules and needle crystals of calcium oxalate.Powder: Yellowish-brown or greyish-brown. Epidermal yellow or yellowish-brown, subrounded or oblong in lateral view, 24-78µm in diameter, covered with cuticle. Stone cells pale yellow or yellow, subsquare, fusiform, eliptical or irregular-shaped walls relatively thick, pit the canals distinct. Fibers in cortex pale yellow or yellow, 27 70µm in diameter with heavy thickened walls and a narrow lumen. Needle crystals of calcium oxalate small occuring in parenchymatous cells.2. Heat under reflux 2g of the powder in 2oml of 70% ethanol for 30 minutes, cool and filter. Evaporate the filtrate to dryness, dissolve the residue in 10ml of hydrochloric acid solution (1?50) and filter. Adjust the filtrate to alkaline with ammonia TS and extract with 10 ml of chloroform. Separate the chloroform layer, evaporate to dryness, dissolve the residue in 5ml of hydrochloric acid solution (1?50). Add the solution separately to three test tubes, to the first tube add 2 drops of potassium iodobismuthate TS, an orange precipitate is produced. To the second add 2 drops of mercuric potassium iodide TS a pale yellow precipitate is produced, to the last tube add 2 drops of silicotungsic acid TS, a greyish-white precipitate is produced.3.Heat under reflux 2g of the powder with 25ml of ethanol on a water bath for 1 hour and filter. Evaporate the filtrate to dryness. Dissolve the residue in 1 ml of ethanol as the test solution. Dissolve sinominine CRS in ethanol to produced a solution containing 1mg per ml as the r3ference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G prepared with 2% solution of sodium hydroxide as the coating substance and the upper layer of a mixture of toluene-ethyl-acetate-methanol-water (2:4:2:1) standing below 10ºC as the mobile phase. Apply separately to the plate 5µl of each of the two solutions. After developing and removal of the plate, dry it in the air, spray with potassium iodobimuthate TS and sodium nitrite in ethanol TS, successively. The brown spot in the chromatogram obtained with the test solution correspond in the position and colour to the spot in the chromatogram obtained with the reference solution.Total ash: not more than 6.0%

Processing  : eliminate foreign matter, soak briefly, soften thoroughly, cut into thin slices and dry.

Action  : To relieve rheumatic conditions, to remove obstruction of the channels and collaterals, and to cause diuresis.

Indication  :

Precautions  :

Dosage  : 6 to 12 g.

Storage  : Preserve in a dry place.

Synonymns for Sinomenium acutum

Patent Medicines and Medicines with Multiple Ingredients that include Sinomenium acutum

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Sinomenium acutum in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Tong Xu, Tingting Kuang, Huan Du, Qi Li, Tu Feng, Yi Zhang, Gang Fan
Magnoflorine: A review of its pharmacology, pharmacokinetics and toxicity.
Pharmacol. Res.: 2020, 152;104632
[PubMed:31911246] [WorldCat.org] [DOI] (I p)

Yifan Wu, Zeng Lin, Zijian Yan, Zhanghong Wang, Xin Fu, Kehe Yu
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
Int. Immunopharmacol.: 2019, 75;105715
[PubMed:31310911] [WorldCat.org] [DOI] (I p)

Zheng-Meng Jiang, Lan-Jin Wang, Han-Qing Pang, Yong Guo, Ping-Ting Xiao, Chu Chu, Long Guo, E-Hu Liu
Rapid profiling of alkaloid analogues in Sinomenii Caulis by an integrated characterization strategy and quantitative analysis.
J Pharm Biomed Anal: 2019, 174;376-385
[PubMed:31202880] [WorldCat.org] [DOI] (I p)

Chong Peng, Qing-Ping Shi, Jia-Yan Liu, Yan-Jun Lv, Jing Li, Lang Yi, Sha-Sha Bai, Liang Liu, Pei-Xun Wang, Hua Zhou, Ke-Er Huang, Yan Dong
Alpha7 nAChR Expression Is Correlated with Arthritis Development and Inhibited by Sinomenine in Adjuvant-Induced Arthritic Rats.
Evid Based Complement Alternat Med: 2019, 2019;3759304
[PubMed:31186658] [WorldCat.org] [DOI] (P e)

Le-Nyu Gao, Bing Zhong, Yong Wang
Mechanism Underlying Antitumor Effects of Sinomenine.
Chin J Integr Med: 2019, 25(11);873-878
[PubMed:30826933] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects