Santalum album

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Other Names:

Historical Use of Santalum album

Santalum album in Traditional Chinese Medicine


Chinese Name (pinyin): Tanxiang

Chinese Name  :

Common Name  :Sandlewood

Specific Name  : Lignum santali albi

Scientific Name:
Collection  :

Description  : In cylindrical woody segment, varying in length, some somewhat curved, usually about 1m long, 10 - 30cm in diameter. Externally pale yellow or yellowish brown, fine and smooth, some with nodal scars or longitudinal cracks, transversely cut surface brownish yellow, showing oil stains. Brown annual rings distinct or indistinct, longitudinally cut surface showing straight striations. Texture compact, uneasily broken, odour aromatic, strongly aromatic on burning, taste slight, slightly pungent on chewing.

Identification  : 1.Transverse section: Vessels scattered singly, 2 - 3 aggregated occasionally. Wood rays consisting of 1 - 2 rows of radially elongated cells. The differences between wood fibre and fibre tracheid indistinct. Wood parenchymatous cells scattered singly or several aggregated in vessels, ray cells and wood parenchymatous cells.2.To the volatile oil obtained under the assay, add ether to produce a solution containing 10 µl per ml as the test solution. Dissolve santalol CRS in ether to produce a solution containing 5µl per ml ( or the volatile oil of India Sandalwood add ether to produce a solution containing 10µl per ml) as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and petroleum ether (60 - 90ºC)-ethyl acetate (85 -15) as the mobile phase. Apply separately to the plate 10µl of each of the two solution. After developing and removal of the plate, dry it in the air and spray with þ-dimethylaminobenaldehyde solution (dissolve 0.25 of þ-dimethylaminobenaldehyde in 50g of glacial acetic acid, add 5g of 85% phosphoric acid and 20ml of water, mix well), heat at 80 - 90ºC for minutes. The purplish blue spot in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference solution.Water: Carry out the method for the determination of water (Appendix lX H, method 2), not more than 12.0%Assay: Carry out the method for the determination of volatile oil (Appendix X D) using 30g of the wood shavings of the drug (1mm thick). It contains not less than 3.0% of volatile oil (ml/g).

Processing  : Eliminate foreign matter, cut into slices or saw into small sections and split to small pieces.

Action  : To promote the flow of qi in the heart, to warm the spleen and stomach, to increase appetite, and to relieve pain.

Indication  : pectoral and abdominal pain due to stagnation of qi by cold; epigastric pain with anorexia; angina pectoris in coronary heart disease

Precautions  :

Dosage  : 2 to 5 g.

Storage  : Preserve in a cool and dry place.

Synonymns for Santalum album

Patent Medicines and Medicines with Multiple Ingredients that include Santalum album

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Santalum album in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Devyani Shukla, Megha Das, Dipanshu Kasade, Maneesha Pandey, Ashutosh Kumar Dubey, Sanjeev Kumar Yadav, Avanish Singh Parmar
Sandalwood-derived carbon quantum dots as bioimaging tools to investigate the toxicological effects of malachite green in model organisms.
Chemosphere: 2020, 248;125998
[PubMed:32006833] [] [DOI] (I a)

Wenlong Zha, Tianyue An, Ting Li, Jianxun Zhu, Ke Gao, Zhenjiao Sun, Wendong Xu, Pengcheng Lin, Jiachen Zi
Reconstruction of the Biosynthetic Pathway of Santalols under Control of the GAL Regulatory System in Yeast.
ACS Synth Biol: 2020;
[PubMed:31940436] [] [DOI] (I a)

Tomoyuki Sato, Midori A Arai, Yixizhuoma, Yasumasa Hara, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity.
J Nat Med: 2019;
[PubMed:31863259] [] [DOI] (I a)

Zhancui Dang, Shanshan Su, Guoen Jin, Xingmei Nan, Lan Ma, Zhanqiang Li, Dianxiang Lu, Rili Ge
Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat.
J Ethnopharmacol: 2020, 250;112470
[PubMed:31862407] [] [DOI] (I p)

Haifeng Yan, Mingzhi Li, Yuping Xiong, Jianming Wu, Jaime A Teixeira da Silva, Guohua Ma
Int J Mol Sci: 2019, 20(22);
[PubMed:31766135] [] [DOI] (I e)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects