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Pepper is a non-scientific common name that may refer to a number of plant species and varieties.


Other Names:

Historical Use of Pepper

Pepper in Traditional Chinese Medicine


Historical Use of Pepper in Western Medicine

Quote Paraph: "The inhalation of fumes from a mixture of myrrh, ginger, pepper, ammonium salts and black cumin was recommended, as an additional way of administering anti-epileptic substances analogous to the way Avicenna said the ancient Greeks treated the disorder by inhalation of the fumes of the peony flower."
Sec Auth: Eadie MJ and Bladin PF
Title: A Disease Once Sacred. John Libbey & Company Ltd, 2001
Page: 177
Source: A Disease Once Sacred, John Libbey & Company Ltd, 2001, M.J. Eadie and P.F. Bladin
Complete: Eadie MJ, Bladin PF. A disease once sacred: a history of the medical understanding of epilepsy. Eastleigh: John Libbey; 2001. p. 177.
Primary Source:


Synonymns for Pepper

Patent Medicines and Medicines with Multiple Ingredients that include Pepper

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Pepper in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Dan Zhu, Wei-Guang Zhang, Xue-Dan Nie, Si-Wen Ding, Dong-Tai Zhang, Lei Yang
Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy.
J. Photochem. Photobiol. B, Biol.: 2020, 205;111805
[PubMed:32092661] [] [DOI] (I a)

Mario Mastrangelo, Chiara Alfonsi, Isabella Screpanti, Laura Masuelli, Barbara Tavazzi, Davide Mei, Flavia Giannotti, Renzo Guerrini, Vincenzo Leuzzi
Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.
Mol Genet Metab Rep: 2019, 21;100502
[PubMed:31467849] [] [DOI] (P e)

Tianjing Ren, Min Xiao, Mengbi Yang, Jiajia Zhao, Yufeng Zhang, Mengyun Hu, Yan Cheng, Hong Xu, Chunbo Zhang, Xiaoyu Yan, Zhong Zuo
Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.
AAPS J: 2019, 21(5);90
[PubMed:31321577] [] [DOI] (I e)

Tianjing Ren, Mengyun Hu, Yan Cheng, Tsum Lam Shek, Min Xiao, Nicolas James Ho, Chunbo Zhang, Sharon Shui Yee Leung, Zhong Zuo
Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control.
Eur J Pharm Sci: 2019, 137;104988
[PubMed:31291598] [] [DOI] (I p)

Tianjing Ren, Mengbi Yang, Min Xiao, Junjie Zhu, Wen Xie, Zhong Zuo
Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment.
Life Sci.: 2019, 218;314-323
[PubMed:30611786] [] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects