Melia Toosendan

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Nomenclature

Other Names:

Historical Use of Melia Toosendan

Melia Toosendan in Traditional Chinese Medicine

Background

Kuliangenpi ¿à鬸ùƤ Chinese Name (pinyin): Kulianpi

Chinese Name  :

Common Name  :Chinaberry Bark

Specific Name  : Cortex meliae

Scientific Name:
Collection  : The drug is ollected in spring and autumn, dried in the sun after removal of the coarse outer layer.

Description  : Irregular tabular, channeled or semiquilled, varying in length and width, 2-6mm thick, outer surface greyish brown, rough with interwoven longitudinal wrinkles and dotted greyish-brown lenticels, yellowish when the outer layer is peeled, inner surface whitish or pale yellow. Texture tough, uneasily broken, fracture fibrous, laminated, easily separated. Odourless, taste bitter.

Identification  : 1.Choose any section of the drug, when folded and rubbed with hands it may be laminated. The lamination appearing alternately yellow and white layers with each lamina minutely reticulated.2.Macerate about 1g of the powder with 10ml of ether for 2 hours with constant shaking and filter. Evaporate 1ml of the filtrate to dryness, add several drops of p-dimethyllaminobenzaldehyde TS dropwise, a red colour is produced. Evaporate 1ml of the filtrate to dryness in a test tube, add 1ml of acetic anhydride, stir, add several drops of sulfuric acid along the tube wall, a green colour in acetic anhydride layer , a red to purple colour in sulfuric acid layer are produced.

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into slivers and dry.

Action  : To repel worms and cure dermatosis.

Indication  : ascariasis, oxyutiasis, abdominal pain due to intestinal parasitosis external: scabies, tinea

Precautions  : Used with caution in patients with hepatitis or nephritis.

Dosage  : 4.5 to 9 g; for external use, appropriate quantity to be ground into powder and applied topically after mixed with lard.

Storage  : Preserve in a ventilated dry place, protected from moisture.

P264 2.jpg
P264 1.jpg
P263 3.jpg
P47 2.jpg
P47 3.jpg
Tcm p52 0006.jpg

Nomenclature

Other Names:

Historical Use of Melia Toosendan

Melia Toosendan in Traditional Chinese Medicine

Background

Jinlingzi ½ðÁå×Ó Chinese Name (pinyin): Chuanlianzi

Chinese Name  :

Common Name  :Toosendan Fruit

Specific Name  : Fructus Meliae Toosendan

Scientific Name:
Collection  : he drug is collected in winter when ripe. Remove from foreign matter and dried.

Description  : Subspherical, 2 - 3.2cm in diameter, externally golden to brownish yellow, somewhat lustrous, rarely dented or shrunken with deep brown small dots. Apex with remains of style attached, base with dent and a fruit stalk scar. Epicarp leathery, usually forming a space with sarcocarp loose and soft, pale yellow viscous when moistened with water. Kernels spherical or ovoid, texture hard, both ends truncate with 6 - 8 longitudinal ribs and 6 - 8 loculi, each loculus containing a blackish brown oblong seed. Odor characteristic, taste sour and bitter.

Identification  :

Processing  : Eliminate foreign matter, break to pieces before use.Stir fried : Cut and clean, thick slices or pulverize. Stir fry the drug as described under the method for simple stir frying (Appendix ll D) until the outer surface turns brown.

Action  :

Indication  : pain in the chest, hypochondrium and epigastrium; colic in the lower abdomen, abdominal pain due to parasitosis

Precautions  :

Dosage  :

Storage  :

P264 2.jpg
P264 1.jpg
P263 3.jpg
P47 2.jpg
P47 3.jpg
Tcm p52 0006.jpg

Nomenclature

Other Names:

Historical Use of Melia Toosendan

Melia Toosendan in Traditional Chinese Medicine

Background

Jinlingzi ½ðÁå×Ó Chinese Name (pinyin): Chuanlianzi

Chinese Name  :

Common Name  :Toosendan Fruit

Specific Name  : Fructus Toosendan

Scientific Name:
Collection  : he drug is collected in winter when ripe. Remove from foreign matter and dried.

Description  : Subspherical, 2 - 3.2cm in diameter, externally golden to brownish yellow, somewhat lustrous, rarely dented or shrunken with deep brown small dots. Apex with remains of style attached, base with dent and a fruit stalk scar. Epicarp leathery, usually forming a space with sarcocarp loose and soft, pale yellow viscous when moistened with water. Kernels spherical or ovoid, texture hard, both ends truncate with 6 - 8 longitudinal ribs and 6 - 8 loculi, each loculus containing a blackish brown oblong seed. Odor characteristic, taste sour and bitter.

Identification  :

Processing  : Eliminate foreign matter, break to pieces before use.Stir fried : Cut and clean, thick slices or pulverize. Stir fry the drug as described under the method for simple stir frying (Appendix ll D) until the outer surface turns brown.

Action  :

Indication  : pain in the chest, hypochondrium and epigastrium; colic in the lower abdomen, abdominal pain due to parasitosis

Precautions  :

Dosage  :

Storage  :

Synonymns for Melia Toosendan

Patent Medicines and Medicines with Multiple Ingredients that include Melia Toosendan

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Melia Toosendan in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Victor Jaoko, Clauvis Nji Tizi Taning, Simon Backx, Jackson Mulatya, Jan Van den Abeele, Titus Magomere, Florence Olubayo, Sven Mangelinckx, Stefaan P O Werbrouck, Guy Smagghe
##Title##
Plants (Basel): 2020, 9(2);
[PubMed:31979199] [WorldCat.org] [DOI] (P e)

Bixin Tang, Kunlun Wu, Qingyi Meng, Fang Wang
Comparison of the Analgesic and Anti-Inflammatory Effects of Xiaoyuningkun Decoction with Cynanchum Paniculatum and Fukeqianjin in a Mouse Model of Pelvic Inflammatory Disease.
Med. Sci. Monit.: 2019, 25;9094-9102
[PubMed:31784502] [WorldCat.org] [DOI] (I e)

Huining Fan, Wei Chen, Jinshui Zhu, Jing Zhang, Shiqiao Peng
Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling.
Int. Immunopharmacol.: 2019, 76;105909
[PubMed:31520988] [WorldCat.org] [DOI] (I p)

Tian Gao, An Xie, Xuqiang Liu, Haibo Zhan, Jin Zeng, Min Dai, Bin Zhang
Toosendanin induces the apoptosis of human Ewing's sarcoma cells via the mitochondrial apoptotic pathway.
Mol Med Rep: 2019, 20(1);135-140
[PubMed:31115517] [WorldCat.org] [DOI] (I p)

Xiaojing Yan, Yue Zhuo, Xiqing Bian, Jianmin Li, Yida Zhang, Lidong Ma, Guanghua Lu, Ming-Quan Guo, Jian-Lin Wu, Na Li
Integrated Proteomics, Biological Functional Assessments, and Metabolomics Reveal Toosendanin-Induced Hepatic Energy Metabolic Disorders.
Chem. Res. Toxicol.: 2019, 32(4);668-680
[PubMed:30848893] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects