Inula helenium

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Nomenclature

Other Names:

Historical Use of Inula helenium

Inula helenium in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Tumuxiang

Chinese Name  :

Common Name  :Inula Root

Specific Name  : Radix inulae

Scientific Name:
Collection  : The drug is collected in autumn, remove from soil and dried in the sun.

Description  : Conical slightly curved, 5 - 20 cm long. Externally yellowish brown or dark brown with longitudinal wrinkles and rootlet scars. The root stock large with sunken stem scar and remains of leaf sheath at the apex. Surrounded by cylindrical numerous rootlets. Texture hard, uneasily broken, fracture slightly even, yellowish white to pale greyish yellow, showing dented dotted oil cavities. Odour slightly aromatic, taste bitter and pungent.

Identification  : 1.Transverse section: Cork consisting of several layers of cells. Phloem broad. Cambium ring less distinct. Xylem rays 6 - 25 cells wide. Vessels less frequent, singly scattered or several aggregated in groups, radiately arranged, wood fibre rare in bundle present in surroundings of vessels at the center of xylem. Parenchymatous cells containing inulin. Oil cavities scattered in phloem and xylem, 80 - 300 µm in diameter.Powder: pale yellow brown. Inulin abundant, colourless in irregular pieces. Retyiculated vessels 30 - 100 µm in diameter. Cork cells polygonal, yellowish brown. Wood fibres long fusiform with oblique ends and oblique pits.2.Heat under reflux 1 g of the powder in 5 ml of methanol for 5 minutes and filter. To 1 ml of the filtrate add slowly 0.5 ml of sulfuric acid along the tube wall. A brownish red ring is produced at the junction of the two layers.3.To 0.5g of the powder add 4 ml of methanol, tightly stoppered, shake aloow to stand for 30 minutes and filter. Use the filtrate in the test solution. Dissolve alantolactone CRS and isoalantolactone CRS in mtehanol to produced a solution containing 2 mg of each per ml use as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing 0.25% silver nitrate as the coating substance and petroleum ether (60 - 90ºC)-benzene-ethyl acetate (75:15:15) as the mobile phase. Apply separately to the plate 5 µl of each of the two solutions. After developing, protected from light and removal of the plate, dry it in the air. Spray with 5% anisaldehyde-sulfuric acid solution. Visualize under a current of hot air. The two bluish violet spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into slices and dry in the sun.

Action  : To invigorate the spleen and regulate the function of stomach, to relieve the depression of the liver qi, to alleviate pain, and to prevent abortion.

Indication  :

Precautions  :

Dosage  : 3 to 9 g, mostly used in making pills or powder.

Storage  : Preserve in a cool and dry place.

P16 2.jpg
P16 1.jpg

Nomenclature

Other Names:

Historical Use of Inula helenium

Inula helenium in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Tumuxiang

Chinese Name  :

Common Name  :Inula Root

Specific Name  : Radix inulae

Scientific Name:
Collection  : The drug is collected in autumn, remove from soil and dried in the sun.

Description  : Conical slightly curved, 5 - 20 cm long. Externally yellowish brown or dark brown with longitudinal wrinkles and rootlet scars. The root stock large with sunken stem scar and remains of leaf sheath at the apex. Surrounded by cylindrical numerous rootlets. Texture hard, uneasily broken, fracture slightly even, yellowish white to pale greyish yellow, showing dented dotted oil cavities. Odour slightly aromatic, taste bitter and pungent.

Identification  : 1.Transverse section: Cork consisting of several layers of cells. Phloem broad. Cambium ring less distinct. Xylem rays 6 - 25 cells wide. Vessels less frequent, singly scattered or several aggregated in groups, radiately arranged, wood fibre rare in bundle present in surroundings of vessels at the center of xylem. Parenchymatous cells containing inulin. Oil cavities scattered in phloem and xylem, 80 - 300 µm in diameter.Powder: pale yellow brown. Inulin abundant, colourless in irregular pieces. Retyiculated vessels 30 - 100 µm in diameter. Cork cells polygonal, yellowish brown. Wood fibres long fusiform with oblique ends and oblique pits.2.Heat under reflux 1 g of the powder in 5 ml of methanol for 5 minutes and filter. To 1 ml of the filtrate add slowly 0.5 ml of sulfuric acid along the tube wall. A brownish red ring is produced at the junction of the two layers.3.To 0.5g of the powder add 4 ml of methanol, tightly stoppered, shake aloow to stand for 30 minutes and filter. Use the filtrate in the test solution. Dissolve alantolactone CRS and isoalantolactone CRS in mtehanol to produced a solution containing 2 mg of each per ml use as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing 0.25% silver nitrate as the coating substance and petroleum ether (60 - 90ºC)-benzene-ethyl acetate (75:15:15) as the mobile phase. Apply separately to the plate 5 µl of each of the two solutions. After developing, protected from light and removal of the plate, dry it in the air. Spray with 5% anisaldehyde-sulfuric acid solution. Visualize under a current of hot air. The two bluish violet spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into slices and dry in the sun.

Action  : To invigorate the spleen and regulate the function of stomach, to relieve the depression of the liver qi, to alleviate pain, and to prevent abortion.

Indication  :

Precautions  :

Dosage  : 3 to 9 g, mostly used in making pills or powder.

Storage  : Preserve in a cool and dry place.

P16 2.jpg
P16 1.jpg

Nomenclature

Other Names:

Historical Use of Inula helenium

Inula helenium in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Tumuxiang

Chinese Name  :

Common Name  :Inula Root

Specific Name  : Radix inulae

Scientific Name:
Collection  : The drug is collected in autumn, remove from soil and dried in the sun.

Description  : Conical slightly curved, 5 - 20 cm long. Externally yellowish brown or dark brown with longitudinal wrinkles and rootlet scars. The root stock large with sunken stem scar and remains of leaf sheath at the apex. Surrounded by cylindrical numerous rootlets. Texture hard, uneasily broken, fracture slightly even, yellowish white to pale greyish yellow, showing dented dotted oil cavities. Odour slightly aromatic, taste bitter and pungent.

Identification  : 1.Transverse section: Cork consisting of several layers of cells. Phloem broad. Cambium ring less distinct. Xylem rays 6 - 25 cells wide. Vessels less frequent, singly scattered or several aggregated in groups, radiately arranged, wood fibre rare in bundle present in surroundings of vessels at the center of xylem. Parenchymatous cells containing inulin. Oil cavities scattered in phloem and xylem, 80 - 300 µm in diameter.Powder: pale yellow brown. Inulin abundant, colourless in irregular pieces. Retyiculated vessels 30 - 100 µm in diameter. Cork cells polygonal, yellowish brown. Wood fibres long fusiform with oblique ends and oblique pits.2.Heat under reflux 1 g of the powder in 5 ml of methanol for 5 minutes and filter. To 1 ml of the filtrate add slowly 0.5 ml of sulfuric acid along the tube wall. A brownish red ring is produced at the junction of the two layers.3.To 0.5g of the powder add 4 ml of methanol, tightly stoppered, shake aloow to stand for 30 minutes and filter. Use the filtrate in the test solution. Dissolve alantolactone CRS and isoalantolactone CRS in mtehanol to produced a solution containing 2 mg of each per ml use as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing 0.25% silver nitrate as the coating substance and petroleum ether (60 - 90ºC)-benzene-ethyl acetate (75:15:15) as the mobile phase. Apply separately to the plate 5 µl of each of the two solutions. After developing, protected from light and removal of the plate, dry it in the air. Spray with 5% anisaldehyde-sulfuric acid solution. Visualize under a current of hot air. The two bluish violet spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into slices and dry in the sun.

Action  : To invigorate the spleen and regulate the function of stomach, to relieve the depression of the liver qi, to alleviate pain, and to prevent abortion.

Indication  :

Precautions  :

Dosage  : 3 to 9 g, mostly used in making pills or powder.

Storage  : Preserve in a cool and dry place.

Synonymns for Inula helenium

Patent Medicines and Medicines with Multiple Ingredients that include Inula helenium

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Inula helenium in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Ning Ji, Sun-Gun Kim, Hyo-Hyun Park, Eujin Lee, Youn Ju Lee, Meihua Jin, Eunkyung Lee
Nepetin, a natural compound from Inulae flos, suppresses degranulation and eicosanoid generation through PLCγ1 and Akt signaling pathways in mast cells.
Arch. Pharm. Res.: 2020;
[PubMed:32016828] [WorldCat.org] [DOI] (I a)

Patrizia Virdis, Rossana Migheli, Grazia Galleri, Silvia Fancello, Maria Piera L Cadoni, Giorgio Pintore, Giacomo Luigi Petretto, Irene Marchesi, Francesco Paolo Fiorentino, Alessandra di Francesco, Francesca Sanges, Luigi Bagella, Maria Rosaria Muroni, Claudio Fozza, Maria Rosaria De Miglio, Luigi Podda
##Title##
Tumour Biol.: 2020, 42(2);1010428319901061
[PubMed:32013807] [WorldCat.org] [DOI] (I p)

Thien T P Dao, Kwangho Song, Jee Young Kim, Yeong Shik Kim
Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.
Inflamm. Res.: 2020, 69(3);309-319
[PubMed:32002586] [WorldCat.org] [DOI] (I p)

Xinru Jiang, Yijian Chen, Dan Liu, Ting Shi, Xiaodong Cheng, Weigang He, Yinhong Li, Bernhard Ryffel, Song Guo Zheng, Yuejuan Zheng
Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae.
J Ethnopharmacol: 2020, 252;112605
[PubMed:31981749] [WorldCat.org] [DOI] (I a)

Keru Shi, Xinyue Liu, Getao Du, Xiaoxia Cai, Yonghua Zhan
In vivo antitumour activity of Britanin against gastric cancer through nuclear factor-κB-mediated immune response.
J. Pharm. Pharmacol.: 2020;
[PubMed:31943207] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects