Euphorbia lathyris

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P38 1.jpg

Nomenclature

Other Names:

Historical Use of Euphorbia lathyris

Euphorbia lathyris in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Qianjinzi

Chinese Name  :

Common Name  :Caper Euphorbia Seed

Specific Name  : Semen euphorbiae

Scientific Name:
Collection  : The drug is collected in summer and autumn when the fruit is ripe, removed from foreign matters and dried.

Description  : Ellipsoidal or ovoid, about 5 mm long, 4mm in diameter. Externally greyish brown with irregular reticulated wrinkles, greyish black in the dents of reticulated pits, forming fine spots. A longitudinally furrowed raphe occurring on one side, a protrudent chalaza at the apex, a linear raphe at the lower end and an almost white raised caruncle or its scar at the base. Testa thin and fragile, kernel white or yellowish white, oily. Slight odor and taste pungent.

Identification  : 1.Transverse section: Epidermal cells of testa undulated, outer wall relatively thickened containing brown contents. Hypodermis consisting of 1 - 3 layers of parenchymatous cells, the inner epidermis consisting of 1 layer of subsquare palisade cells, the inner part of lateral walls and inner walls thickened distinctly. Palisade cells of endotesta 1 row, brown, slender cylindrical with thickened and lignified walls, sometimes pits visible. Perisperm consisting of several layers of sub-square parenchymatous cells. Cells of endosperm sub-rounded, cells of cotyledons square or rectangular. All containing aleurone grains.2.To 2g of the powder in a Soxhlet's extractor add 80 ml of petroleum ether (30 - 60ºC). Heat under reflux on a water bath for 30 minutes and filter. To the residue add 80ml of ethanol, heat under reflux on a water bath for 1 hour, cool, filter, evaporate the filtrate to dryness. Dissolve the residue in 10ml of ethanol and use it at the test solution. Dissolve esculetin CRS in ethanol to produce a solution containing 1mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carbobexymethyl cellulose as the coating substance and toluene-ethyl acetate-formic acid (5: 4: 1) as the mobile phase. Apply separately 5 µl of the test solution and 1 µl of the reference solution to the plate. After developing and removal of the plate, dry it in the air. Examine under ultra violet light (365 nm). The bright bluish fluorescent spot in the chromatogram obtained with the test solution correspond in position and color to the spot in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matters, sift and wash clean, dry in the sun. Break into pieces before use.Semen Euphorbiae Pulveratum: Rub off the testa clean Semen Euphorbiae, wrap with a piece of paper. Bake until the fatty oil is expelled entirely, discard paper, cool, or pulverized the drug, wrap it with a piece of paper and bake by gently heat, remove the fatty oil by pressing then pulverize to fine powder.

Action  : To cause drastic purgation for treating edema, and eliminate blood stasis for treating masses.

Indication  : edema, retained fluid with abdominal extension, oliguria, constipation, amenorrhea due to blood stasis. External use for tinea, verrucae

Precautions  : Contraindicated in pregnancy or debility with loose bowels.

Dosage  : 1 to 2 g without shell and oil, usually made into pills or powder; for external use, appropriate quntity to be pounded into paste and applied topically.

Storage  : Preserve in a cool and dry place, potected from moth.

P38 1.jpg

Nomenclature

Other Names:

Historical Use of Euphorbia lathyris

Euphorbia lathyris in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Qianjinzi Shuang

Chinese Name  :

Common Name  :

Specific Name  : Semen euphorbiae pulveratum

Scientific Name:
Collection  :

Description  : Homogeneous and loose light yellow powder. Slightly oleaginous and taste pungent.

Identification  : Complies with Identification test (2) described under Semen Euphorbiae.Assay: Transfer 5g weighed accurately to a Soxhlet's extractor and 100 ml of ethanol and heat under reflux for 6 - 8 hours to exhaust fatty oil. Collect the extracts to an evaporating dish dried to constant weight and evaporate to dryness at a low temperature on a water bath. Dry it at 100ºC for 1 hour, allow to cool and weighed accurately. It contains not less than 19.0% _ 20.0% of fatty oils.

Processing  : Rub off the testa, carry out the method for frost like powder making (Appendix ll D) to make the frost like powder.

Action  : To cause drastic purgation for treating edema, and eliminate blood stasis for treating masses.

Indication  :

Precautions  : Contraindicated in pregnancy or debility with loose bowels.

Dosage  : 0.5 to 1 g, usually made into pills or powder for external use, appropriate quantity to be applied topically.

Storage  : Preserve in a cool and dry place, potected from moth.

Synonymns for Euphorbia lathyris

Patent Medicines and Medicines with Multiple Ingredients that include Euphorbia lathyris

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Euphorbia lathyris in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Wang Wang, Yanli Wu, Chen Li, Yueying Yang, Xingzhou Li, Hua Li, Lixia Chen
Synthesis of New Lathyrane Diterpenoid Derivatives from Euphorbia lathyris and Evaluation of Their Anti-Inflammatory Activities.
Chem. Biodivers.: 2019;
[PubMed:31825561] [WorldCat.org] [DOI] (I a)

Clément Gastaldo, Agata Lipko, Estelle Motsch, Pierre Adam, Philippe Schaeffer, Michel Rohmer
##Title##
Molecules: 2019, 24(23);
[PubMed:31779240] [WorldCat.org] [DOI] (I e)

Tao Yang, Siyi Wang, Hongmei Li, Qun Zhao, Shili Yan, Miao Dong, Dan Liu, Xuanqin Chen, Rongtao Li
Lathyrane diterpenes from Euphorbia lathyris and the potential mechanism to reverse the multi-drug resistance in HepG2/ADR cells.
Biomed. Pharmacother.: 2020, 121;109663
[PubMed:31751870] [WorldCat.org] [DOI] (I p)

An Zhu, Zonghui Ji, Jingwei Zhao, Wenjing Zhang, Yuqing Sun, Tao Zhang, Shan Gao, Guojun Li, Qi Wang
Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans.
Phytomedicine: 2019, 65;153102
[PubMed:31654989] [WorldCat.org] [DOI] (I p)

An Zhu, Yuqing Sun, Qianwen Zhong, Jinlan Yang, Tao Zhang, Jingwei Zhao, Qi Wang
Effect of euphorbia factor L1 on oxidative stress, apoptosis, and autophagy in human gastric epithelial cells.
Phytomedicine: 2019, 64;152929
[PubMed:31454650] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects