Dichroa febrifuga

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Nomenclature

Other Names:

Historical Use of Dichroa febrifuga

Dichroa febrifuga in Traditional Chinese Medicine

Background

Cuchangshan ´×³£É½ Huangchangshan »Æ³£É½ Jiguchangshan ¼¦¹Ç³£É½ Jiuchangshan ¾Æ³£É½ Chinese Name (pinyin): Changshan

Chinese Name  :

Common Name  :Dichroa Root

Specific Name  : Radix dichroae

Scientific Name:
Collection  : The drug is collected in autumn, removed from rootlet, wash clean and dried in the sun.

Description  : Cylindrical, often twisted or branched, 9 - 15 cm long, 0.5 - 2 cm in diameter. Externally brownish yellow with fine longitudinal striations, the outer bark easily exfoliated, exposing pale yellow wood. Texture hard uneasily broken, dusting on breaking, transversely cut surface yellowish white, rays whitish, arranged relatively. Odorless and taste bitter.

Identification  : 1.Transverse section: Cork consisting of several layers of cells. Cortex narrow, a few cells containing resinous masses raphides of calcium oxalate. Phloem narrow, raphides of calcium oxalate numerous, cambium in irregular wavy ring. Xylem occupying the main part, completely lignified, rays varying in width, vessels polygonal, singly scattered or aggregated, some containing yellow tyloses. Parenchymatous cells containing starch granules.2.Heat under reflux 2 g of the powder with 10ml of 70% ethanol for 15 minutes, allow to cool and filter. Evaporate the filtrate to dryness, add 2 ml of 1% hydrochloric acid solution to the residue, stir and filter. To the filtate add 2 drops of potassium iodobismuthate TS, a brownish red precipitate is produced.

Processing  : Eliminate foreign matter, grade according to size, soak in water, soften thoroughly, cut into thin slices and dry in the sun.

Action  : To stop malarial attacks.

Indication  : malaria

Precautions  : It causes vomiting as a side effect; overdosage should be avoided. Used with caution in pregnancy.

Dosage  : 5 to 9 g.

Storage  : Preserve in a ventilated and dry place.

Synonymns for Dichroa febrifuga

Patent Medicines and Medicines with Multiple Ingredients that include Dichroa febrifuga

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Dichroa febrifuga in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Hai-Lian Du, Ai-Dong Zhai, Hong Yu
Synergistic effect of halofuginone and dexamethasone on LPS‑induced acute lung injury in type II alveolar epithelial cells and a rat model.
Mol Med Rep: 2020, 21(2);927-935
[PubMed:31974595] [WorldCat.org] [DOI] (I p)

Wenjie Dai, Hsin-Yi Chen, Calvin Yu-Chian Chen
A Network Pharmacology-Based Approach to Investigate the Novel TCM Formula against Huntington's Disease and Validated by Support Vector Machine Model.
Evid Based Complement Alternat Med: 2018, 2018;6020197
[PubMed:30643534] [WorldCat.org] [DOI] (P e)

Shaun Smullen, Noel P McLaughlin, Paul Evans
Chemical synthesis of febrifugine and analogues.
Bioorg. Med. Chem.: 2018, 26(9);2199-2220
[PubMed:29681487] [WorldCat.org] [DOI] (I p)

Wenbo Mu, Boyong Xu, Hairong Ma, Jiao Li, Baochao Ji, Zhendong Zhang, Abdusami Amat, Li Cao
Halofuginone Attenuates Osteoarthritis by Rescuing Bone Remodeling in Subchondral Bone Through Oral Gavage.
Front Pharmacol: 2018, 9;269
[PubMed:29636687] [WorldCat.org] [DOI] (P e)

Linghui Luo, Yong Gao, Cao Yang, Zengwu Shao, Xinghuo Wu, Shuai Li, Liming Xiong, Chao Chen
Halofuginone attenuates intervertebral discs degeneration by suppressing collagen I production and inactivating TGFβ and NF-кB pathway.
Biomed. Pharmacother.: 2018, 101;745-753
[PubMed:29524883] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects