- 1 Nomenclature
- 2 Historical Use of Coptis deltoidea
- 3 Background
- 4 Pharmaceutical Information
- 5 Evidence or the Use of Coptis deltoidea in the Treatment of Epilepesy
- 6 Safety
Historical Use of Coptis deltoidea
Coptis deltoidea in Traditional Chinese Medicine
Chinese Name (pinyin): Huanglian
Chinese Name :
Common Name :Coptis Root
Specific Name : Rhizoma coptidis
Collection : The drug is collected in autumn, removed from rootlet and soil and dried.
Description : Rhizome of Coptidis Chinensis: Frequently gathered to a clusters, curved like chicken feet single rhizome, 3 - 6 cm long, 3 - 8 mm in diameter. Externally greyish yellow or yellowish brown, rough bearing irregular nodula protrudings, rootlets and remains of rootlets, some internodes smooth as stem. The upper part mostly remained with brown scale leaves, apex often bearing remains of stem of petioles. Texture hard, fracture uneven, bark orange red or dark brown, wood brightly yellow or orange yellow, radially arranged, pith sometimes hollowed. Odour slight, taste very bitter.Rhizome of Coptidis deltoidea: Frequently single, somewhat cylindrical, slightly curved, 4 - 8 cm long, 0.5 - 1 cm in diameter. Internodes smooth and relatively long. Apex with some remains of stem.Rhizome of Coptidis teeta: Curved hook like, frequrntly single, relatively small.
Identification : 1.Transverse section: Rhizome of Coptidis: Cork cells several layers, cortex broader, stone cells singly scattered or grouped. Pericycle fibres in bundles or accompanied with a few stone cells both yellow. Collateral vascular bundles arranged in a ring. Interfascicular cambium indistinct. Xylem yellow lignified, xylem fibres well developed. Pith consisting of parenchymatous cells, stone cells absent.Rhizome of Copitidis deltoida: Pith with stone cells.Rhizome of Coptidis Teeta: In cortex pericycle and pith stone cells absent.2.To 1 g of the coarse powder, add 10 ml of ethanol, heat to boil, allow to cool and filter. To 5 drops of the filtrate, add 1 ml of diluted hydrochloric acid TS and small quantity of chlorinated lime. A red color is produced, to another 5 drops of the filtrate add 2 - 3 drops of 5% solution of gallic acid in ethanol, evaporate to dryness. Add several drops of sulfuric acid to the residue while hot, a dark green colour is produced.3.To 50 mg of the powder, add 5 ml of methanol, heat under reflux on a water bath for 15 minutes, filter. Add methanol to 5 ml as the test solution. Prepare a solution of Rhizoma Coptidis reference drug in the same manner as the reference drug solution. Dissolve berberine hydrochloride CRS in methanol to produce a solution containing 0.5mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and benzene-ethyl acetate-isopropanol-water (6:3:1.5:0.3) as the mobile phase. Apply to the plate 1 µl each of the three solutions. After developing in a chamber pre-saturated with the vapour of concentrated ammonia TS for 15 minutes and removal of the plate, dry it in the air and examine under ultra violet light (365 nm). The yellow fluorescent spot in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference drug solution. A yellow fluorescent spot due to berberine correspond to the spot in the chromatogram obtained with the reference solution.Total ash: Not more than 5.0% (Appendix lX K)Assay: Weigh accurately 0.1g of the powder in a 100 ml volumetric flask, add 95 ml hydrochloric aicd methanol (1:100), heat at 60ºC on a water bath for 15 minutes, ultrasonicate for 30 minutes, allow to stand overnight, dilute with methanol to volume, mix well, filter, use the filtrate as the test solution. Dissolve berberine hydrochloride CRS, weighed accurately in methanol to produced a solution containing 0.04 mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and benzene-ethyl acetate-isopropanol-water (6:3:1.5:0.3) as the mobile phase. Apply 1 µl of the test solution and 1 µl, 3 µl of the reference solution alternately to the plate. After developing 8 cm in a chamber pre-saturated with the vapor of concentrated ammonia TS for 15 minutes and removal of the plate, dry it in the air. Carry out the method for thin layer chromatography (Appendix Vl B) (thin layer chromatographic scanning method), scan with fluorescence mode at a wavelength of Ûex=366nm, measure the integration value of the flourescent strength and calculate. It contains not less than 3.6% of berberine, calculated as berberine hydrochloride (C20H18CINO4).
Processing : Eliminate foreign matter, soften thoroughly, cut into thin slices, dry it in the air or break to pieces before use.Rhizoma Coptidis (processed with wine): Stir fry as described under the method for stir frying with wine (Appendix ll D)- to dryness, using 12.5 kg of yellow rice wine per 100 kg of Rhizoma Coptidis.Processed with vinegar: Stir fry as described under the method for stir frying with ginger juice (Appendix ll D) to dryness using 12.5 kg of Rhizoma Coptidis.Processed with Fructus Evodiae: Decoct Fructus Evodiae with a quantity of water, mix the decoction with clean Rhizoma Coptidis until the decoction is exhausted then stir fry to dryness. To each 100 kg of Rhizoma Coptidis add 10 kg of Fructus Evodiae. Carry out the method for determination of total ash as described above, for all these processed products not more than 4.0%.
Action : To remove damp-heat, quench fire and counteract toxicity. Rhizoma Coptidis (processed with wine): To remove fire from the upper part of the body. Rhizoma Coptidis (processed with ginger): to remove fire from the stomach, regulate the stomach function and
Indication : attack of damp-heat manifested by stuffiness and fullness sensation in the abdomen, or causing acute dysentery of jaundice; high fever accompanied by impairment of consciousness; fidgetness and insomnia due to exuberant fire; spitting of blood and epistaxis caused by heat in the blood; inflammation of the eye; acid regurgitationl; toothache; diabetes; carbuncles and sores external: eczema and other skin diseases with exudation; purulent discharge from the ear; processed with wine: inflammation of the eye; ulcers in the mouth processed with ginger: stuffiness and fullness sensation in the abdomen with nausea and vomiting caused by damp-heat in combination with cold processed with Fructus Evodia: nausea, vomiting and acid regurgitation in disharmony of the liver and the stomach
Dosage : 2 to 5 g; appropraite quantity for esternal use.
Storage : Preserve in a ventilated and dry place.
Synonymns for Coptis deltoidea
Patent Medicines and Medicines with Multiple Ingredients that include Coptis deltoidea
Evidence or the Use of Coptis deltoidea in the Treatment of Epilepesy
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Randomized Controlled Trials
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