Cnidium monnieri

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Nomenclature

Other Names:

Historical Use of Cnidium monnieri

Cnidium monnieri in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Shechuangzi

Chinese Name  :

Common Name  :Cnidium Fruit

Specific Name  : Fructus cnidii

Scientific Name:
Collection  : The drug is collected in summer or autumn when ripe, removed from foreign matter and dried in the sun.

Description  : Cremecarp, ellipsoidal, 2 - 4mm long, about 2mm in diameter. Externally greyish yellow or greyish brown, with 2 outcurved stylopods at the summit and sometimes with a fine fruit stlk at the base. Dorsal surface of mericarp with fie thin and longitudinal ridges, commissural surface flattened with two brown and slightly raised longitudinal ribs. Pericarrp lax and fragile, easily rubbed off, seed small, greyish brown and oily. Odor aromatic, taste pungent, cool and numb.

Identification  : 1.Transverse section of mericarp: Epicarp composed of 1 layer of flattened, cuticularized cells. Mesocarp relatively thick, longitudinal ridges extremely raised with vascular bundles in the middle, surrounded by thick-walled and lignified reticulate cells, dorsal surface showing 1 ellipsoidal vitta between every 2 longitudinal ridges, commissural surface showing 2 vittae altogether up to 6. Endocarp consisting of 1 layer of flattened cells with beaded walls. Testa consisting of 1 layer of pale brown cells. Cells of endosperm conatining numerous aleurone grains, each embedding with fine clusters of calcium oxalate.2.To 2g of the powder add 20ml of ethanol, heat under reflux for 30 minutes and filter. Spots several drops of the filtrate on a white porcelain plate. Examine under ultra violet light (365nm), a bluish purple fluorescence is shown. To 2ml of the filtrate add and equal volume of 3% sodium carbonate solution and heat for 5 minutes. Allow to cool. Add 1 - 2 drops of reshly prepared diazotized p-nitroaniline TS, a cherry color is produced.3.To about 0.3g of the coarse powder, add 5ml of ethanol, ultrasonicate for 5 minutes, lay aside for a while and use the supernate as the test solution. Dissolve osthol CRS with ethanol to produce a solution containing 1mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carboxymethylcellulose as the coating substance and benzene-ethyl acetate (30:1) as the mobile phase. Apply separately 2µl of each of the two solutions to the plate. After developing and removal of the plate, dry it in the air and examine it under ultra violet light (365nm). The fluorescent spot in the chromatogram obtained with the test solution corresponds in position and color to spot in the chromatogram obtained with the reference solution.Assay: Weigh accurately 1 g of the powder (through no.3 sieve), previously dried in vacuum in a phosphorus pentoxide desiccator to constant weight into a stoppered conical flask. Add accurately 20 ml of ethanol, shake and allow to stand overnight, filter, discard the primary filtrate and collect the successive filtrate as the test solution. Disolve osthol CRS in ethanol to produce a solution containing 1mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carboxymethylcellulose as the coating substance and benzene-ethyl acetate (30:1) as the mobile phase. Apply separately 1µl of each of the two solution to the plate, after developing and removal of the plate, dry it in tha air. Carry out the method for thin layer chromatogaphic scanning (Appendix Vl B), apply the linear fluorescent scanning at excitation wave ?=365nm. Determine the integral fluorescence absorbance value of test solution and reference solution respectively and calculate the content of the asthol. It contains not les than 1.0% of osthol (C10H16O3)

Processing  :

Action  : To warm the kidney and promote virility, to remove damp, to dispel wind, and to kill parasites.

Indication  : impotence, frigidity, excessive leukorrhea caused by cold-damp; lumbago due to attack of damp external: eczema of external genitalia, vulval itching, trichomonas vaginitis

Precautions  :

Dosage  : 3 to 9 g; appropriate quantity to be made into hot decoction for fuming and washing, or to be ground into powder for topical application after mix with liquid.

Storage  : Preserve in a dry place.

Synonymns for Cnidium monnieri

Patent Medicines and Medicines with Multiple Ingredients that include Cnidium monnieri

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Cnidium monnieri in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Jing Liang, Jianlong Zhou, Youqin Xu, Xiaofei Huang, Xuefei Wang, Wenhua Huang, Hui Li
Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis.
Eur. J. Pharmacol.: 2020, 874;172990
[PubMed:32057718] [WorldCat.org] [DOI] (I a)

Yue Sun, Angela Wei Hong Yang, George Binh Lenon
##Title##
Int J Mol Sci: 2020, 21(3);
[PubMed:32028721] [WorldCat.org] [DOI] (I e)

Biao Yan, Qiu Yang Zhang, Shuya Tao, Chang Lu, Jingjing Li, Xiumiao Li, Qin Yiang
Osthole: a Traditional Chinese Medicine for Ocular Anti-angiogenic Therapy.
Ophthalmic Res.: 2020;
[PubMed:31945770] [WorldCat.org] [DOI] (I a)

Ya-Han Chen, Dong-Sheng Guo, Mei-Huan Lu, Jian-Ying Yue, Yan Liu, Chun-Ming Shang, De-Rong An, Ming-Min Zhao
##Title##
Molecules: 2019, 25(1);
[PubMed:31878172] [WorldCat.org] [DOI] (I e)

Jing Yang, Xin-Jiang Zhu, Ming-Zhu Jin, Zhi-Wei Cao, Yao-Yao Ren, Zhao-Wei Gu
Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway.
Chem. Biol. Interact.: 2019, 316;108934
[PubMed:31870840] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects