Clematis manshurica

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Nomenclature

Other Names:

Historical Use of Clematis manshurica

Clematis manshurica in Traditional Chinese Medicine

Background

Tielingxian ÌúÁéÏÉ Chinese Name (pinyin): Weilingxian

Chinese Name  :

Common Name  :Clematis Root

Specific Name  : Radix clematidis

Scientific Name:
Collection  : The drug is collected in autumn, removed from soil and dried in the sun.

Description  : Root of Clematis hexapetala: Rhizomes short cylindrical, 1 - 4cm long, 0.5 - 2.5 cm in diameter. Roots 4 - 20 cm long, 1 - 2 mm in diameter, externally brown to brownish black, wood in fracture subrounded, taste salty.

Identification  : Extractives: Carry out the hot extraction method as described under the determination of ethanol-soluble extractives (Appendix X A), use ethanol as the solvent, not less than 15.0%. Transverse section of root Exodermis cells mostly radially elongated and the adjacent 1 - 2 rows of cells with slightly thickened walls, the outer side of phloem without fibre bundles and stone cells.

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into sections and dry.

Action  : To relieve rheumatic conditions, to remove obstruction of collaterals, and to alleviate pain.

Indication  : rheumatic or rheumatoid arthralgia with numbness of the limbs, muscle contracture and limitation of motion; fishbone stuck in the throat

Precautions  :

Dosage  : 6 to 9 g.

Storage  : Preserve in a dry place.

Synonymns for Clematis manshurica

Patent Medicines and Medicines with Multiple Ingredients that include Clematis manshurica

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Clematis manshurica in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Jiwon Jeong, Kiljoon Bae, Jihoon Kim, Chanhun Choi, Changsu Na, Myeongkyu Park, Youngran Kim, Chang-Seob Seo, Seon-Jong Kim
A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats.
BMC Complement Altern Med: 2019, 19(1);367
[PubMed:31830971] [WorldCat.org] [DOI] (I e)

Rui Hong Guo, Seon-Jong Kim, Chan-Hun Choi, Chang-Su Na, Bok Yun Kang, Young Ran Kim
Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis.
BMC Complement Altern Med: 2019, 19(1);319
[PubMed:31747910] [WorldCat.org] [DOI] (I e)

Yi Li, Jia-Yi Zheng, Jian-Qun Liu, Jie Yang, Yang Liu, Chen Wang, Xiao-Nan Ma, Bao-Lin Liu, Gui-Zhong Xin, Li-Fang Liu
Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis.
Front Immunol: 2016, 7;532
[PubMed:28003810] [WorldCat.org] [DOI] (P e)

Yang Zhou, Yue Guan, Ji Shi, Xiaolin Zhang, Lan Yao, Lifang Liu
Development and validation of a chromatographic method for determining Clematichinenoside AR and related impurities.
Chem Cent J: 2012, 6(1);150
[PubMed:23216920] [WorldCat.org] [DOI] (I e)

Wang Han, Ying Xiong, Yunman Li, Weirong Fang, Yan Ma, Lifang Liu, Fengwen Li, Xingxiang Zhu
Anti-arthritic effects of clematichinenoside (AR-6) on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis.
Pharm Biol: 2013, 51(1);13-22
[PubMed:22994412] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects