- 1 Nomenclature
- 2 Historical Use of Atractylodes macrocephala
- 3 Background
- 4 Pharmaceutical Information
- 5 Evidence or the Use of Atractylodes macrocephala in the Treatment of Epilepesy
- 6 Safety
Historical Use of Atractylodes macrocephala
Atractylodes macrocephala in Traditional Chinese Medicine
Chinese Name (pinyin): Baizhu
Chinese Name :
Common Name :Bighead Atractylodes Rhizoma
Specific Name : Rhizoma atracylodis macrocephalae
Collection : The drug is collected in winter while the lower leaf of the plant turns yellow and the upper leaf becomes fragile, removed from soil, baked or sunned to dryness and then removed from fibrous root.
Description : In irregular plump masses, 3 - 13 cm long, 1.5 - 7 cm in diameter. Externally greyish yellow or greyish brown with warty prutrudings, interrupt longitudinal wrinkles and glooves and scars of fibrous rootlets. Remains of stems and bud scars attached to the apex. Texture hard, uneasily broken, fracture uneven, yellowish white to brownish, scattered with brownish yellow dotted oil cavities. The material dried by baking appearing horny and relatively deep colored or cracked. Odour aromatic, taste sweetish and slightly pungent, viscous in chewing.
Identification : 1.Powder: Yellowish brown, needle crystals of calcium oxalate minute, 10 - 32 µm long, irregularly aggregated in parenchymatous cells, a few needle crystals up to 4 µm in diameter. Fibres yellow, mostly in bundles, long fusiform up to about 40 µm in diameter, walls fairly thickened, lignified with distinct pit canals. Stone cells yellowish, sub rounded, polygonal, rectangular, rarely fusiform, 37 - 64 µm in diameter. Parenchymatous cells containing inulin with radial striations. Vessel elements short, reticulate and bordered pitted up to 48 µm in diameter2.Shake 2 g of the powder with 20 ml of ether for 10 minutes and filter. Evaporate 10 ml of the filtrate to dryness, add 10% solution of vanillin in sulfuric acid, a violet colour is produced. Apply 1 drop of the filtrate to a piece of filter paper, dry it in the air and spray with 1% solution of vanillin in sulfuric acid, a pink colour is produced.3.To 0.5g of the powder add 2 ml of n-hexane, ultrasonicate for 15 minutes, filter and use the filtrate as the test solution. Prepare a solution of Rhizoma Atractylodis Macrocephalae reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substances and petroleum ether (60 - 90ºC)-ethyl acetate (50:1) as the mobile phase. Apply separately to the plate 10 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and spray with 5% solution of vanillin in sulfuric acid, visualized with a current hot air. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference drug solution, and same pink principal spot (atractylone) is shown in both chromatograms.Total ash: Not more than 5% (Appendix lX K)Acid insoluble ash: Not more than 1.0% (Appendix lX K)Degree of discoloration: Weigh accurately 2 g of the very coarse powder to a 100 ml of stopper flask, add 50 ml of 55% ethanol, adjust pH value to 2 - 3 with dilute hydrochloric acid, shake for 1 hour and centrifuge at 4000 rpm for 15 minutes. Measure 10 ml of the supernatant and same volume of reference solution (dilute a mixture of 5 ml of standard ferric chloride CS. 3 ml of standard cobaltous chloride CS and 0.6ml of standard copper sulfate CS to 10 ml o9f water) separately into two Nestler cylinder's view vertically against to a piece of white paper. The color of the test solution should not be deeper then that of the reference solution.
Processing : Eliminate foreign matter, wash clean, soften thoroughly cut into thick slices and dry.Rhizoma Atractylodis Macocephalae (processed with terra): Stir fry the slices with fine powder of Terra Flova Usta until the outer surface ashen and sift, using 20 kg of powder of Terra Flova Usta for 100 kg of the slices.Rhizoma Atractylodis Macocephalae (processed with bran): Cast the bran stir fried with honey in a hot pot, while smoking, add the slices, stir well until they become burnt yellow with burnt aroma, take out and sift the bran. To each 100 kg of bran stir fried with honey.
Action : To invigorate the function of the spleen and replenish qi, to eliminate damp by causing diuresis, to arrest excessive perspiration, nd to prevent miscarriage. Rhizoma Atractylodis macrocephalae (processed with terra): Hypofuntion of the spleen with anorex
Indication : hypofunction of the spleen with anorexia, abdominal distension and diarrhea; dizziness and palpitation due to retention of phlegm and fluid; edema; spontaneous sweating; impending abortion
Dosage : 6 to 12 g.
Storage : Preserve in a cool and dry place, protected from moth.
Synonymns for Atractylodes macrocephala
Patent Medicines and Medicines with Multiple Ingredients that include Atractylodes macrocephala
Evidence or the Use of Atractylodes macrocephala in the Treatment of Epilepesy
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
1st Five Results: pubmed search