White Hellebore

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White Hellebore is a non-scientific common name that may refer to a number of plant species and varieties.


Other Names:

Historical Use of White Hellebore

White Hellebore in Traditional Chinese Medicine


Historical Use of White Hellebore in Western Medicine

Quote Paraph: "botanical materials and preparations were also described for the treatment of epilepsy. These included: white hellebore contained within a split radish; root of the panaces (heraclion) in a drink with seal's rennet; plantain; betony; agaric in oxymel; leaves of cinquefoil; archezostis; dried root of baccar plus coriander; centunculus in vinegar or honey or hot water; varvain taken in wine; crushed berries of hyssop; peucedanus and seal's rennet taken in a drink; scammony in beaver-oil; hippophaestron; senecio."
Sec Auth: Eadie MJ and Bladin PF
Title: A Disease Once Sacred. John Libbey & Company Ltd, 2001
Page: 171
Source: A Disease Once Sacred, John Libbey & Company Ltd, 2001, M.J. Eadie and P.F. Bladin
Complete: Eadie MJ, Bladin PF. A disease once sacred: a history of the medical understanding of epilepsy. Eastleigh: John Libbey; 2001. p. 171.
Primary Source: Pliny the Elder, Gaius Plinius Secundus, Natural History: Books XXV to XXXII (Translated Jones WHS 1951 and Translated Jones WHS in 1963)


Synonymns for White Hellebore

Patent Medicines and Medicines with Multiple Ingredients that include White Hellebore

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of White Hellebore in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Pei Li, Jie Shen, Zhiqiang Wang, Shuangshuang Liu, Qing Liu, Yue Li, Chunnian He, Peigen Xiao
Genus Paeonia: A comprehensive review on traditional uses, phytochemistry, pharmacological activities, clinical application, and toxicology.
J Ethnopharmacol: 2021, 269;113708
[PubMed:33346027] [WorldCat.org] [DOI] (I p)

K Laios, P Lytsikas-Sarlis, K Manes, M-I Kontaxaki, M Karamanou, G Androutsos
Drugs for mental illnesses in ancient greek medicine.
Psychiatriki: 2019, 30(1);58-65
[PubMed:31115355] [WorldCat.org] [DOI] (I p)

Yue Cong, Yu-Bo Zhou, Jing Chen, Yi-Mei Zeng, Jin-Hui Wang
Alkaloid profiling of crude and processed Veratrum nigrum L. through simultaneous determination of ten steroidal alkaloids by HPLC-ELSD.
J Pharm Biomed Anal: 2008, 48(3);573-8
[PubMed:18599245] [WorldCat.org] [DOI] (P p)

Yoojin Choi, Paul R Borghesani, Jennifer A Chan, Rosalind A Segal
Migration from a mitogenic niche promotes cell-cycle exit.
J Neurosci: 2005, 25(45);10437-45
[PubMed:16280582] [WorldCat.org] [DOI] (I p)

Therapeutics and toxicology.
Annu Rev Med: 1950, 1;391-418
[PubMed:14771861] [WorldCat.org] [DOI] (P p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects