Vitex trifolia var. simplicifolia

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Tcm p5514 01 022.jpg


Other Names:

Historical Use of Vitex trifolia var. simplicifolia

Vitex trifolia var. simplicifolia in Traditional Chinese Medicine


Chinese Name (pinyin): Manjingzi

Chinese Name  :

Common Name  :Fruit of Shrub Chastetree

Specific Name  : Fructus viticis

Scientific Name:
Collection  : The drug is collected from autumn when ripe. Removed from foreign matter and dried in the sun.

Description  : Spheroidal, 4 - 6mm in diameter, externally greyish black or blackish brown, covered with greyish white frost like hairs, bearing 4 longitudinal shallow furrows, apex slightly concave with greyish white, persistent calyx and short fruit stalk at the base. Calyx is 1/3 - 2/3 length of the fruit, 5 toothed, 2 of them relatively deep, covered with densely pubescent. Texture light and hard, uneasily broken. Transverse section showing 4 loculi, each with one seed. Odour characteristic and aromatic, taste weak and slightly pungent.

Identification  : Powder: Greyish brown, epidermal cells of calyx subrounded, walls frequently sinous, non-glndular hairs 2 - 3 celled, apical cell relatively wide with warty protrudings. Cells of epicarp polygonal with cuticle striations and scar of the hairs bearing glandular hairs and non-glandular hairs in two types. One with a unicellular head and a 1 - 2 celled stalk and the other a 2 -6 celled, 14 - 68µm long, often curved, warty walled. Cells of mesocarp oblong or subrounded, walls slightly lignified and with distinct pits. Vittae frequently broken containing secretions, adjacent cells containing pale yellow oil droplets. Stone cells of endocarp elliptical or subsquare. 10 - 35µm in diameter. Cells of testa rounded or subrounded, 42 - 73µm in diameter with reticulate striated and lignified walls.

Processing  : Eliminate foreign matterStir fried: Clean, stir fry gently as describe under the method for simple stir frying (Appendix ll D), break to pieces before use.

Action  :

Indication  : headache in upper respiratory tract infection; painful swelling of the gums; inflammation of the eye with lacrimation, blurring of vision and dizziness

Precautions  :

Dosage  :

Storage  :

Synonymns for Vitex trifolia var. simplicifolia

Patent Medicines and Medicines with Multiple Ingredients that include Vitex trifolia var. simplicifolia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Vitex trifolia var. simplicifolia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Mabel Guevara, Luis A Valdés-Silverio, María G Granda-Albuja, Gabriel Iturralde, Tatiana Jaramillo-Vivanco, Francesca Giampieri, Celestino Santos-Buelga, Ana M González-Paramás, Maurizio Battino, José M Álvarez-Suarez
Antioxidants (Basel): 2020, 9(2);
[PubMed:32012759] [] [DOI] (P e)

Mohammad Moghaddam, Leila Mehdizadeh, Zahra Sharifi
Macro- and microelement content and health risk assessment of heavy metals in various herbs of Iran.
Environ Sci Pollut Res Int: 2020;
[PubMed:31993898] [] [DOI] (I a)

Shriniwas P Patil
Heliyon: 2020, 6(1);e03171
[PubMed:31993516] [] [DOI] (P e)

Gulsah Yildiz Deniz, Esra Laloglu, Serdar Altun, Nimet Yiğit, Arzu Gezer
Antioxidant and anti-apoptotic effects of vitexilactone on cisplatin-induced nephrotoxicity in rats.
Biotech Histochem: 2020;1-8
[PubMed:31961202] [] [DOI] (I a)

Xue-Jun Wang, Jin-Yang Chen, Luo-Qin Fu, Mei-Juan Yan
Recent advances in natural therapeutic approaches for the treatment of cancer.
J Chemother: 2020;1-13
[PubMed:31928332] [] [DOI] (I a)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects