Vitex trifolia

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Other Names:

Historical Use of Vitex trifolia

Vitex trifolia in Traditional Chinese Medicine


Chinese Name (pinyin): Manjingzi

Chinese Name  :

Common Name  :Fruit of Shrub Chastetree

Specific Name  : Fructus Viticis

Scientific Name:
Collection  : The drug is collected from autumn when ripe. Removed from foreign matter and dried in the sun.

Description  : Spheroidal, 4 - 6mm in diameter, externally greyish black or blackish brown, covered with greyish white frost like hairs, bearing 4 longitudinal shallow furrows, apex slightly concave with greyish white, persistent calyx and short fruit stalk at the base. Calyx is 1/3 - 2/3 length of the fruit, 5 toothed, 2 of them relatively deep, covered with densely pubescent. Texture light and hard, uneasily broken. Transverse section showing 4 loculi, each with one seed. Odour characteristic and aromatic, taste weak and slightly pungent.

Identification  : Powder: Greyish brown, epidermal cells of calyx subrounded, walls frequently sinous, non-glndular hairs 2 - 3 celled, apical cell relatively wide with warty protrudings. Cells of epicarp polygonal with cuticle striations and scar of the hairs bearing glandular hairs and non-glandular hairs in two types. One with a unicellular head and a 1 - 2 celled stalk and the other a 2 -6 celled, 14 - 68µm long, often curved, warty walled. Cells of mesocarp oblong or subrounded, walls slightly lignified and with distinct pits. Vittae frequently broken containing secretions, adjacent cells containing pale yellow oil droplets. Stone cells of endocarp elliptical or subsquare. 10 - 35µm in diameter. Cells of testa rounded or subrounded, 42 - 73µm in diameter with reticulate striated and lignified walls.

Processing  : Eliminate foreign matterStir fried: Clean, stir fry gently as describe under the method for simple stir frying (Appendix ll D), break to pieces before use.

Action  :

Indication  : headache in upper respiratory tract infection; painful swelling of the gums; inflammation of the eye with lacrimation, blurring of vision and dizziness

Precautions  :

Dosage  :

Storage  :

Synonymns for Vitex trifolia

Patent Medicines and Medicines with Multiple Ingredients that include Vitex trifolia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Vitex trifolia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Jun Chu, Bo Yan, Jie Zhang, Lilan Peng, Xiang Ao, Zhenyu Zheng, Tao Jiang, Zhongmin Zhang
Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.
Inflammation: 2020;
[PubMed:31897918] [] [DOI] (I a)

Motohiko Ukiya, Daisuke Sato, Hirokazu Kimura, Mamoru Koketsu, Nyunt Phay, Atsuyoshi Nishina
Molecules: 2019, 25(1);
[PubMed:31878261] [] [DOI] (I e)

Trilokesh Chandrasekaran, Aishwarya Thyagarajan, Prabhakaran Ganapathi Santhakumari, Agiesh Kumar Balakrishna Pillai, Uma Maheswari Krishnan
Larvicidal activity of essential oil from Vitex negundo and Vitex trifolia on dengue vector mosquito Aedes aegypti.
Rev. Soc. Bras. Med. Trop.: 2019, 52;e20180459
[PubMed:31365621] [] [DOI] (I e)

Ashwini Prasad, Aishwarya Tripurasundari Devi, M N Nagendra Prasad, Farhan Zameer, Govindaraju Shruthi, Chandan Shivamallu
3 Biotech: 2019, 9(2);53
[PubMed:30729077] [] [DOI] (P p)

Anahita Boveiri Dehsheikh, Mohammad Mahmoodi Sourestani, Paria Boveiri Dehsheikh, Sara Vitalini, Marcello Iriti, Javad Mottaghipisheh
Foods: 2019, 8(2);
[PubMed:30717330] [] [DOI] (P e)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects