Uncaria macrophylla

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Other Names:

Historical Use of Uncaria macrophylla

Uncaria macrophylla in Traditional Chinese Medicine


Nengouteng ÄÛ¹³ÌÙ Shuangouteng Ë«¹³ÌÙ Chinese Name (pinyin): Gouteng

Chinese Name  :

Common Name  :Hooked Uncaria

Specific Name  : Ramulus uncariae cum uncis

Scientific Name:
Collection  : The drug is collected in autumn and winter, removed from leaf, cut into section and dried in the sun.

Description  : Cylindrical or subsquare, 2 - 3 cm long, 2 - 5 mm in diameter. Externally reddish brown to purplish red with fine longitudinal striations, glabrous or yellowish green to greyish brown. Sometimes with white dotted lenticels covered with yellowish brown pubescence. Most nodes of stem branch with two opposite downward curved hooks (sterile peduncles). Some only with a hook at one side and with raised scars at the other side, hooks relatively flattened or rounded, apex acute, base relatively broad, dotted scars of falling petiole and ring shaped stipule scars visible on the branch at the hook base. Texture hard and tenacious, fracture yellowish brown, bark fibrous, pith yellowish white or hollowed. Odourless, taste weak.

Identification  : Moisten 1 g of the powder with concentrated ammonia, add 30 ml of chloroform, extract for 30 minutes, filter and evaporate the filtrate to dryness. Dissolve the residue in 5 ml of hydrochloric acid solution (1Õ100). Filter into three test tubes. To the first tube add 1 - 2 drops of potassium iodobismuthate TS, a yellow precipitate is produced, to the second tube add 1 - 2 drops of mercuric potassium iodide TS, a white precipitate is produced. To the third tube add 1 - 2 drops of silicontungstic acid TS, a white precipitate is produced.

Processing  :

Action  : To remove heat, subdue hyperactivity of the liver, and arrest convulsions.

Indication  : headache, dizziness, convulsion, eclampsia, hypertension

Precautions  :

Dosage  : 3 to 12 g, to be added when the decoction is nearly done.

Storage  : Preserve in a dry place.

Synonymns for Uncaria macrophylla

Patent Medicines and Medicines with Multiple Ingredients that include Uncaria macrophylla

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Uncaria macrophylla in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Jian-Gang Zhang, Xiao-Yan Huang, Yun-Bao Ma, Ji-Jun Chen, Chang-An Geng
UFLC-PDA-MS/MS Profiling of Seven Uncaria Species Integrated with Melatonin/5-Hydroxytryptamine Receptors Agonistic Assay.
Nat Prod Bioprospect: 2020;
[PubMed:31933166] [WorldCat.org] [DOI] (P a)

Jian-Gang Zhang, Ji-Jun Chen, Chang-An Geng
[Advances in indole alkaloids from traditional Chinese medicine of Uncariae Ramulus Cum Uncis documented in Chinese Pharmacopoeia].
Zhongguo Zhong Yao Za Zhi: 2019, 44(4);685-695
[PubMed:30989880] [WorldCat.org] [DOI] (P p)

Mei-Fang Song, Yan-Hong Guan, Hai-Tao Li, Shu-Gen Wei, Li-Xia Zhang, Zhong-Lian Zhang, Xiao-Jun Ma
The effects of genetic variation and environmental factors on rhynchophylline and isorhynchophylline in Uncaria macrophylla Wall. from different populations in China.
PLoS ONE: 2018, 13(6);e0199259
[PubMed:29953548] [WorldCat.org] [DOI] (I e)

Wenzhi Yang, Yibei Zhang, Huiqin Pan, Changliang Yao, Jinjun Hou, Shuai Yao, Luying Cai, Ruihong Feng, Wanying Wu, Dean Guo
Supercritical fluid chromatography for separation and preparation of tautomeric 7-epimeric spiro oxindole alkaloids from Uncaria macrophylla.
J Pharm Biomed Anal: 2017, 134;352-360
[PubMed:27843099] [WorldCat.org] [DOI] (I p)

Yin-Lin Tang, Yao-Sheng Wu, Rui-Song Huang, Nai-Xia Chao, Yong Liu, Peng Xu, Ke-Zhi Li, Dan-Zhao Cai, Yu Luo
Molecular identification of Uncaria (Gouteng) through DNA barcoding.
Chin Med: 2016, 11;3
[PubMed:26843891] [WorldCat.org] [DOI] (P e)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects