Trichosanthes kirilowii

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Nomenclature

Other Names:

Historical Use of Trichosanthes kirilowii

Trichosanthes kirilowii in Traditional Chinese Medicine

Background

Gualoupi ¹ÏÝäƤ Gualouren ¹ÏÝäÈÊ Gualoushuang ¹ÏÝä˪ Quangualou È«¹ÏÝä Chinese Name (pinyin): Gualou

Chinese Name  :

Common Name  :Trichosanthes Fruit

Specific Name  : Fructus trichosanthis

Scientific Name:
Collection  : The drug is collected with fruit stalk in autumn and dried in ventilated shade.

Description  : Subspherical or broadly ellipsoidal, 7 - 15cm long, 6 - 10 cm in diameter. The outer surface orange red or orange yellow, shrunken or relatively smooth, apex with rounded style scar, base slightly acute with remains of fruit stalk. Varying in weight. Texture fragile, easily split. The inner surface yellowish white with reddish-yellow reticulation, sarcocarp orange yellow. Viscous adhering to many seeds into a mass. Odour, caramel-like, taste slightly sour and sweet.

Identification  :

Processing  : Eliminate fruit stalks and soil, flatten, cut into slivers or pieces.

Action  : To remove heat and eliminate phlegm, to alleviate chest pain, and to facilitate bowel movement.

Indication  : cough with thick purulent sputum; angina pectoris and stuffiness sensation in the chest; mastitis, lung abscess, appendicitis; constipation

Precautions  : Incompatible with aconite and allied drugs.

Dosage  : 9 to 15 g.

Storage  : Preserve in a cool and dry place, protected from mould and moth.

Tcm p52 0014.jpg
Tcm p52 001e.jpg
Tcm p52 0040.jpg
P143 1.jpg
P66 2.jpg
P66 1.jpg
P144 2.jpg
Tcm397.jpg

Nomenclature

Other Names:

Historical Use of Trichosanthes kirilowii

Trichosanthes kirilowii in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Gualoupi

Chinese Name  :

Common Name  :Snakegourd Peel

Specific Name  : Pericarpium trichosanthis

Scientific Name:
Collection  : The drug is collected in autumn when the fruit is ripe, cut, removed from sarcocary and seed and dried in the shade.

Description  : Two to several valves with invalulate edge, 6 - 12cm long. The outer surface orange red or orange yellow, shrunken, sometimes with remains of fruit stalk. The inner surface yellowish whjite. Texture relatively fragile, easily broken. Odour caramel like, taste weak and slightly sour.

Identification  :

Processing  : Wash clean, dry for a moment, cut into sliver and dry in the sun.

Action  : To remove heat and resolve phlegm, and to smooth the flow of qi in the chest.

Indication  : cough with yellowish sticky expectoration, oppressed feeling in the chest coastal pain

Precautions  : Incompatible with Radix Aconiti and allied drugs.

Dosage  : 6 to 9 g.

Storage  : Preserve in a cool and dry place, protected from mould and moth.

Tcm p52 0014.jpg
Tcm p52 001e.jpg
Tcm p52 0040.jpg
P143 1.jpg
P66 2.jpg
P66 1.jpg
P144 2.jpg
Tcm397.jpg

Nomenclature

Other Names:

Historical Use of Trichosanthes kirilowii

Trichosanthes kirilowii in Traditional Chinese Medicine

Background

Gualougen èéÂ¥¸ù Huafen »¨·Û Chinese Name (pinyin): Tianhuafen

Chinese Name  :

Common Name  :Trichosanthes Root

Specific Name  : Radix Trichosanthis

Scientific Name:
Collection  : The drug is collected in autumn and winter, wash clean, peeled, cut into segments or slice longitudinally and dried.

Description  : Irregular cylindrical, spindle shaped or in pieces, 8 - 16 cm long, 1.5 - 5.5 cm in diameter. Externally yellowish white or pale brownish yellow with longitudinal wrinkles, rootlet scars and slightly concave transverse lenticels. Some remained with yellowish brown outer bark. Texture compact, fracture white or yellowish, starchy, wood yellow, somewhat radially arranged in transversely cut section and striated in longitudinally cut section. Odourless, taste slightly bitter.

Identification  : 1.Powder: Whitish, starch granules numerous, simple granules subspheroid, semicircular or helmeted, 6 - 48µm in diameter, hila pointed, shortly cleft or V shaped, striations faintly visible, compound granules consisting of 2 - 8 components. Bordered pitted vessels large, mostly broken, some bordered pits hexagonal or square, closely arranged. Stone cells yellowish green, rectangular elliptical, subsquare, polygonal or fusiform, 27 - 72 µm in diameter, relatively thick walled and densely fine pitted.2.To 2 g of the powder add 20 ml of 50% ethanol, ultrasonicate for 30 minutes, filter, use filtrate as the test solution. Dissolve cittulline CRS in 50% ethanol to produce a solution containing 1 mg per ml use as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and a mixture of n-butanol-absolute ethanol-glacial-water (8:2:2:3) as the mobile phase. Apply separately 6 µl of the test solution, 1 µl of the reference solution to the plate. After developing and removal of the plate, dry it in the air, spray with ninhydrin TS, dry at 105ºC until the coloured spots appear clearly. A spot in the chromatogram obtained from the test solution corresponds in color and position to the spot in the chromatogram obtained from the reference solution

Processing  : Soak briefly, soften thoroughly, cut into thin slices and dry.

Action  :

Indication  : thirst in febrile diseases; dry cough due to heat in the lung; diabetes caused by internal heat; sores and abscesses

Precautions  :

Dosage  :

Storage  :

Tcm p52 0014.jpg
Tcm p52 001e.jpg
Tcm p52 0040.jpg
P143 1.jpg
P66 2.jpg
P66 1.jpg
P144 2.jpg
Tcm397.jpg

Nomenclature

Other Names:

Historical Use of Trichosanthes kirilowii

Trichosanthes kirilowii in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Gualouzi

Chinese Name  :

Common Name  :Snakegourd Seed

Specific Name  : Semen trichosanthis

Scientific Name:
Collection  : The ripe fruit is picked in autumn and dissected. The seed is collected, washed clean and dried in the sun.

Description  : Seed of Trichosanthis Kirilowii: Flattened elliptical, 12 - 15mm long, 6 - 10 mm wide about 3.5mm thick. Externally pale brown to brown, smooth with circle of furrow along the edge. Apex relatively acute with a hilum, base obtuse or relatively narrow. Testa hard, tegmen membraneous, greyish green, 2 cotyledons, yellowish white and oily. Odor slight, taste weak.Seed of Trichosanthis rosthornii: Relatively large and flattened, 15 - 19mm long, 8 - 10 mm wide, about 2.5 mm thick. Externally brown, the circular furrow distinct and rathe near the inner part. Apex even and truncate.

Identification  :

Processing  : Eliminate foreign matters and blighted seeds. Wash clean and dry in the sun. Break to pieces before use.Semen Trichosanthis ((stir fried): Stir fry as described under the method for simple stir frying (Appendix 11 D) until inflated. Break to pieces before use.

Action  : To resolve phlegm and to cause lxation.

Indication  : dry cough with sticky sputum; constipation

Precautions  : Incompatible with aconite and allied drugs.

Dosage  : 9 to 15 g.

Storage  : Preserve in a cool and dry place, protected from mould and moth.

Synonymns for Trichosanthes kirilowii

Patent Medicines and Medicines with Multiple Ingredients that include Trichosanthes kirilowii

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Trichosanthes kirilowii in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Akash Ahuja, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho
##Title##
Evid Based Complement Alternat Med: 2019, 2019;6879346
[PubMed:31929819] [WorldCat.org] [DOI] (P e)

Xiaomei Sun, Xiaobo Xu, Li Song
TKP, a serine protease extracted from Trichosanthes kirilowii, inhibits the migration and invasion of colorectal adenocarcinoma cells by targeting Wnt/β-catenin and Hedgehog/Gli1 signalings.
Phytother Res: 2019;
[PubMed:31854039] [WorldCat.org] [DOI] (I a)

Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Min Jeong Kim, Su-Kyoung Kim, Minkyu Kim, Seok Young Choi, Jeongkoo Park, Hyun Koo Kim, Ji Hye Kim, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu Ko
Synergistic anticancer effect of combined use of Trichosanthes kirilowii with cisplatin and pemetrexed enhances apoptosis of H1299 non-small-cell lung cancer cells via modulation of ErbB3.
Phytomedicine: 2020, 66;153109
[PubMed:31790894] [WorldCat.org] [DOI] (I p)

Bokyung Koo, Ho Jung Bae, Nayeon Goo, Jaehoon Kim, Jihyun Kim, Mudan Cai, In Ho Jung, Kyungnam Cho, Seo Yun Jung, Suk Woo Chang, Dae Sik Jang, Jong Hoon Ryu
A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice.
J. Pharm. Pharmacol.: 2020, 72(1);149-160
[PubMed:31713882] [WorldCat.org] [DOI] (I p)

Su Mi Park, Sang Kyu Jeon, Ok Hyeon Kim, Jung Yun Ahn, Chang-Hyun Kim, Sun-Dong Park, Ju-Hee Lee
##Title##
Chin Med: 2019, 14;43
[PubMed:31624493] [WorldCat.org] [DOI] (P e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects