Sophora tonkinensis

Background

Chinese Name (pinyin): Shandougen

Chinese Name  :

Common Name  :Root of Tonkin Sophora

Specific Name  : Radix sophorae tonkinensis

Scientific Name:
Collection  : The drug is collected in autumn, removed from foreign matter, wash clean and dried.

Description  : Rhizomes irregular nodular, bearing remains of stem at the apex and several roots at the lower part. Roots long-cylindrical, usually branched, varying in length, 0.7 - 1.5 cm in diameter, externally brown to dull brown with irregular longitudinal wrinkles and prominent transversal lenticels. Texture hard, uneasily broken, fracture brownish in bark and pale yellow in wood. Odour bean like, taste very bitter.

Identification  : 1.Transverse section: Cork consisting of several 10 or more layers of cells. The outer 1 - 2 rows of cells in cortex containing prisms of calcium oxalate forming an interrupted ring of crystal cells with lignified and thickened walls. Fibre bundles scattered in cortex and phloem. Cambium in a ring. Xylem develop, rays 1 - 8 cells wide, vessels subrounded, mostly singly scattered or in groups of 2 or more, some containing yellowish brown contents. Xylem fibres grouped scattered. Parenchymatous cells filled with starch granules. A few cells containing prisms.2.Add a few drops of sodium hydroxide TS to the outer cortex, an orange red to blood red colour persists.3.To about 2 g of the powder add 70% ethanol, heat under reflux foe 30 minutes, filter, evaporate the filtrate to dryness. Dissolve the residue in 5 ml of 1% hydrochloric acid solution, filter. To 1 ml of the filtrate add 1 drop of mercuric potassium iodide TS, a distinct pale yellow precipitate is produced.4.Shake 0.5 g of the coarse powder with 10 ml of chloroform and 0.2 ml of concentrated ammonia TS for 15 minutes, filter, evaporate the filtrate to dryness. Dissolve the residue in 0.5 ml of chloroform as the test solution. Dissolve matrine CRS and oxymatrine CRS in chloroform to prepare a solution containing 1 mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carboxymethyl cellulose as the coating substance and chloroform-methanol-concentrated ammonia TS (8:2:0.2) as the mobile phase. Apply separately to the plate 1 - 2 µl of the test solution and 4 - 6 µl of the reference solution. After developing and removal of the plate, dry it in the air, spray with potassium iodobismuthate TS. The orange yellow spots in the chromatogram obtained with test solution correspond in position and color to the spots in the chromatogram obtained with the reference drug solution.

Processing  : Eliminate foreign matter, soak, wash clean, soften thoroughly, cut into thick slices and dry it in the sun.

Action  : To remove toxic heat, promote the subsidence of swelling, and soothe the sore throat.

Indication  : sore throat, painful swelling of the gums to due accumulation of toxic heat

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a dry place.

Evidence or the Use of Sophora tonkinensis in the Treatment of Epilepesy

1st Five Results: pubmed search

Qing-Qing Yang, Yan-Fei Yang, Xuan-Qin Chen, Rong-Tao Li, Zhi-Jun Zhang
Flavonoids from the Aerial Parts of Sophora tonkinensis and Their Potential Anti-inflammatory Activities.
Chem Biodivers: 2024;e202400399
[PubMed:38634752] [WorldCat.org] [DOI] (I a)

Han Liu, Cui Li, Yang Lin, Yi-Jian Chen, Zhan-Jiang Zhang, Kun-Hua Wei, Ming Lei
##Title##
Front Microbiol: 2023, 14;1334338
[PubMed:38260912] [WorldCat.org] [DOI] (P e)

Lili Huang, Yongxia Li, Jing Pang, Liuxia Lv, Jiatong Zhou, Liqi Liang, Xianhua He, Jun Li, Weifeng Xu, Ruiyun Yang
##Title##
Molecules: 2024, 29(2);
[PubMed:38257261] [WorldCat.org] [DOI] (I e)

Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou
Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway.
Fitoterapia: 2024, 172;105756
[PubMed:38007052] [WorldCat.org] [DOI] (I p)

Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun, Xiaobo Sun
Correction: An integrated characterization of contractile, electrophysiological and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes.
Stem Cell Res Ther: 2023, 14(1);310
[PubMed:37904217] [WorldCat.org] [DOI] (I e)