Scutellaria baicalensis

From Epilepsy Naturapedia
Jump to: navigation, search
P397 2.jpg
Tcm137.jpg

Nomenclature

Other Names:

Historical Use of Scutellaria baicalensis

Scutellaria baicalensis in Traditional Chinese Medicine

Background

Huangqintan »ÆÜËÌ¿ Jiuhuangqin ¾Æ»ÆÜË Kuqin ¿ÝÜË Tiaoqin ÌõÜË Ziqin ×ÓÜË Chinese Name (pinyin): Huangqin

Chinese Name  :

Common Name  :Scutellaria Root

Specific Name  : Radix scutellariae

Scientific Name:
Collection  : The drug is collected in spring and autumn, removed from rootlet and soil, dashed to peel the rugged outer bark after being sundried and then dried thoroughly.

Description  : Conical, twisted, 8 - 25 cm long, 1 - 3 cm in diameter. Externally brownish yellow or dark yellow, bearing sparse warty traces of rootlets, the upper part rough with twisted longitudinal wrinkles or irregular reticula, the lower part with longitudinal striations and fine wrinkles. Texture hard and fragile, easily broken, fracture yellow, reddish brown in the center, the several part of an old root dark brown or brownish black, withered or hollowed. Odour slight, taste bitter.

Identification  : 1.Powder: Yellow, phloem fibres scatters singly or in bundles, fusiform. 60 - 250 µm long. 9 - 33 µm in diameter, thick walled with fine pit canals. Stone cells subrounded, subsquare or rectangular, relatively thick walled or heavily thick walled. Cork cells brownish yellow, polygonal. Reticulated vessels numerous, 24 - 72 µm in diameter. Wood fibres frequently broken, about 12 µm in diameter with oblique pits. Starch granules abundant, simple granules spheroidal, 2 - 10 µm in diameter, hila distinct, compound granules composed for 2 - 3 components.2.Heat under reflux 2 g of the powder in 20 ml of ethanol for 15 minutes and filter. To 1 ml of the filtrate add 2 - 3 drops of lead acetate TS, an orange yellow precipitate is produced. To another 1 ml of filtrate, add a small quantity of magnesium powder and 3 - 4 drops of hydrochloric acid, a red color is produced.Total ash: Not more than 6.0% (Appendix lX K)Assay: Carry out the method for high performance liquid chromatography (Appendix Vl D).Chromatographic system and system suitability: Use octadecylsilane bonded silica gel as the stationary phase and methanol-water-phosphoric acid (47:53:0.2) as the mobile phase. The wavelength of the detector is 280 nm. The number of the theoretical plates of the column is not less than 2500 calculated with the reference to the peak of baicalin.Preparation of reference solution: Weigh accurately a quantity of baicalin CRS, dried in vacuum at 60ºC for 4 hours, dissolve in methanol to produced a solution containing 60 µg per ml as the reference solution.Preparation of test solution: Weigh accurately 0.3g of medium powder [perform a determination of water(Appendix lX H, method 1)], add 40 ml of 70% ethanol. Heat under reflux on a water bath for 3 hours, cool and filter. Transfer the filtrate to a 100 ml volumetric flask, wash the container and the residue several times with a small volume of 70% ethanol and filter the washings into the same flask. Dilute with 70% ethanol to volume and mix well. Accurately measure 1 ml in a 10 ml volumetric flask, dilute with methanol to volume and mix well.Procedure: Accurately inject 10 µl of each of the reference solution and the test solution respectively into the column, determine and calculate the content. It contains not less than 9.0% of baicalin (C21H18O11) on the dried basis.

Processing  : Eliminate foreign matter, boil for 10 minutes, take out, soften thoroughly or steam to half an hour, take out the cut into thin slices and dry, protecting from exposure to strong sunlight. Occurring in subrounded or irregular thin slices, externally yellowish brown to brown, cut surface yellowish brown or yellowish green, striated radially.Processed with wine: Stir fry the slices of Radix Scutellariae as described under the method for stir frying with wine (Appendix llD) to dryness. Occurring in subrounded or irregular thin slices, externally brown, cut surface yellowish brown, striated radially, showing less burnt patches, sometimes appearing brown in the center.

Action  : To remove damp-heat, to quench fire and counteract toxicity, to arrest bleeding, and to prevent abortion.

Indication  : discomfort in the chest, nausea and vomiting in epidemic febrile diseases caused by damp-heat or summer-heat; feeling of stuffiness in the abdomen, acute dysentery or jaundice caused by damp-heat; cough due to heat in the lung; high fever with thirst; spitting of blood, epistaxis due to heat in the blood; carbuncles and sores; threatened abortion

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a ventilated dry place, protected from moisture.

Synonymns for Scutellaria baicalensis

Patent Medicines and Medicines with Multiple Ingredients that include Scutellaria baicalensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Scutellaria baicalensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Sailesh Maharjan, Sang Bong Lee, Geum Jin Kim, Sung Jin Cho, Joo-Won Nam, Jungwook Chin, Hyukjae Choi
##Title##
Molecules: 2020, 25(4);
[PubMed:32093002] [WorldCat.org] [DOI] (I e)

Takashi Shii, Minpei Kuroda, Noriko Shamoto, Yoshihiro Mimaki
[An analysis of the ingredients in decoctions and extracts of Kampo medicines: Amounts of baicalin and baicalein in Kampo medicines containing Scutellariae Radix].
Nihon Ronen Igakkai Zasshi: 2020, 57(1);72-80
[PubMed:32074563] [WorldCat.org] [DOI] (I p)

Lianqi Hu, Yaqi Wang, Haojie Sun, You Xiong, Lingyun Zhong, Zhenfeng Wu, Ming Yang
An untargeted metabolomics approach to investigate the wine-processed mechanism of Scutellariae radix in acute lung injury.
J Ethnopharmacol: 2020, 253;112665
[PubMed:32058008] [WorldCat.org] [DOI] (I a)

Jia Song, Yu-Zhi Zhou, Yi-Yuan Pang, Li Gao, Guan-Hua Du, Xue-Mei Qin
The anti-aging effect of Scutellaria baicalensis Georgi flowers extract by regulating the glutamine-glutamate metabolic pathway in d-galactose induced aging rats.
Exp. Gerontol.: 2020;110843
[PubMed:32045633] [WorldCat.org] [DOI] (I a)

Huilian Shi, Yanliang Zhang, Jing Xing, Lina Liu, Fei Qiao, Jun Li, Yuanyuan Chen
Baicalin attenuates hepatic injury in non-alcoholic steatohepatitis cell model by suppressing inflammasome-dependent GSDMD-mediated cell pyroptosis.
Int. Immunopharmacol.: 2020, 81;106195
[PubMed:32028242] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects