Rhaponticum uniflorum

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Nomenclature

Other Names:

Historical Use of Rhaponticum uniflorum

Rhaponticum uniflorum in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Loulu

Chinese Name  :

Common Name  :Uniflower Swisscentaury

Specific Name  : Radix rhapontici

Scientific Name:
Collection  : The drug is collected in spring and autumn, removed from rootlet and soil and dried in the sun.

Description  : Conical or flatted lumps, mostly twisted, varying in length, 1-2 cm in diameter. Externally greyish brown or dark brown, rough with longitudinal furrows and rhombic, netted clefts. Outer bark easily exfoliated. Root stock swollen with the remains of the stem and scaly leaf bases, top with greyish white pubescents. Texture light, fragile, easily broken, fracture irregular, greyish yellow, cleft, greyish black or brownish black in the center. Odour characteristic, taste slightly bitter.

Identification  : To 1 g of the powder add 20 ml of methanol, ultra-sonicate for 20 minutes, filter, evaporate the filtrate on a water bath to dryness. Dissolve the residue in 1 ml of ethyl acetate and use it as the test solution. Prepare a solution of Radix Rhpontici reference drug in the same manner as the reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and cyclohexane butanone (4:1) as the mobile phase. Apply separately 5 µl of each of the two solutions to the plate. After developing and removal of the plate, dry it in the air. Examine under ultra violet light (365 nm). A spot in the chromatogram obtained from the test solution correspond in color to the spot in the chromatogram obtained from the reference drug solution.

Processing  : Eliminate foreign matter, wash, clean soften thoroughly, cut into thick slices and dry in the sun.

Action  : To remove toxic heat for treating subcutaneous infections, to promote lactation, and to relieve muscular contracture.

Indication  : mastitis with swelling and pain, carbuncle, scrofula and ulcers; galactostasis; arthritis with ankylosis

Precautions  : Used with caution in pregnancy.

Dosage  : 5 to 9 g.

Storage  : Preserve in a ventilated and dry place.

Synonymns for Rhaponticum uniflorum

Patent Medicines and Medicines with Multiple Ingredients that include Rhaponticum uniflorum

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Rhaponticum uniflorum in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
##Title##
Front Pharmacol: 2017, 8;870
[PubMed:29218012] [WorldCat.org] [DOI] (P e)

Xin He, Chun-Yan Liu, Ji-Feng Yin, Ai-Hua Jin, Xue-Zhe Yin, Ji-Shu Quan
[Rhaponticum uniflorum inhibits H2O2-induced apoptosis of liver cells via JNK and NF-κB pathways].
Zhongguo Zhong Yao Za Zhi: 2017, 42(6);1189-1193
[PubMed:29027437] [WorldCat.org] [DOI] (P p)

Yong-tao Li, Li Li, Jing Chen, Tian-cen Hu, Jin Huang, Yue-wei Guo, Hua-liang Jiang, Xu Shen
7-Chloroarctinone-b as a new selective PPARgamma antagonist potently blocks adipocyte differentiation.
Acta Pharmacol. Sin.: 2009, 30(9);1351-8
[PubMed:19684608] [WorldCat.org] [DOI] (I p)

Ning Wu, Ting-wen Lei, Hong-mei Li, Qing-qing Wu, Liang-hua Tang
[Effects of Rhaponticum uniflorum on activity and mRNA expression of CYP3A1 in rats hepatocytes].
Zhong Yao Cai: 2007, 30(11);1403-6
[PubMed:18323209] [WorldCat.org] (P p)

Yong-hong Zhang, Jian-gang Zhang, Jie-ming Xie, Ge-lin Chen, Dong-liang Cheng
[Triterpenes from root of Rhaponticum uniflorum].
Zhongguo Zhong Yao Za Zhi: 2005, 30(23);1833-6
[PubMed:16499021] [WorldCat.org] (P p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects