Pueraria lobata

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Nomenclature

Other Names:

Historical Use of Pueraria lobata

Pueraria lobata in Traditional Chinese Medicine

Background

Fengegen ·Û¸ð¸ù Chinese Name (pinyin): Gegen

Chinese Name  :

Common Name  :Pueraria Root

Specific Name  : Radix puerariae

Scientific Name:
Collection  : The drug is collected in autumn and winter. The root of Pueraria lobata (wild). Ohwi is often cut into thick slices or pieces and dried. The root of Pueraria thomsonii Benth, known as "Starchy Radix Puerariae", is often removed from the outer bark, fumigated with sulfur, dried for a while, cut into sections or cut again longitudinally into pieces and dried.

Description  : Root of Pueraria lobata: In irregular thick slices cut longitudinally or small square pieces, 5 - 35 cm long. 0.5 -1 cm thick. The outer bark pale brown with longitudinal wrinkles rough, cut surface yellowish white, striations indistinct. Texture pliable and strongly fibrous, odourless, taste slightly sweetish.Root of Pueraria thomsonii: Cylindrical subfusiform or semicylindrical, 12 - 15 cm long, 4 - 8 cm in diameter. Some longitudinally or obliquely cut thick slices varying in size. Externally yellowish white or pale brown or greyish brown when unpeeled. Transversely cut surface showing pale brown concentric rings form by fibres, longitudinally cut surface showing several longitudinal striations formed by fibres. Heavy texture hard and starchy.

Identification  : 1.Powder: Pale brown, yellowish white or pale yellow. Starch granules abundadnt, simple granules spheroidal, semirounded or polygonal, 3 -37 µm in diameter, hilum pointed, cleft or stellate, compound granules of 2- 10 components. Fibres mostly in bundles, walls thickened and lignified, surrounded by parenchymatous cells mostly containing prisms of calcium oxalate, forming crystal fibres, crystal cells with lignified and thickened walls. Stone cells infrequent visible, subrounded or polygonal. 38 - 70 µm in diameter. Bordered pitted vessels relatively large, pits hexagonal or elliptical, arranged very densely2.Macerate 0.8 g of the powder in 10 ml of methanol for 2 hours, filter and evaporate the filtrate to dryness. Dissolve the residue in 0.5 ml of methanol as the test solution. Dissolve puerarin CRS in methanol to produce a solution containing 1 mg per ml as th reference solutions. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel H containing sodium carbobexycellulose as the coating substance and chloroform-methanol-water (7:2.5:0.25) as the mobile phase. Apply in a strip separately to the plate 10 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and examine under ultra violet light (365 nm). The fluorescence strip in the chromatogram obtained with the test solution correspond in position and color to the strips in the chromatogram obtained with the reference solution.Water: Carry out the method for determination of water (Appendix lX H, method 1), not more than 14.0%Total ash: Radix Pueraria Lobatae: Not more than 7.0% Radix Pueraria Thomsonii: Not more than 5.0%

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into thick pieces and dry in the sun.

Action  : To relieve fever, to promote the production of body fluid, to facilitate eruption, and to arrest diarrhea.

Indication  : fever, headache and stiffness of the neck in exogenous affections, thirst, diabetes, measles with inadequate eruption, acute dysentery or diarrhea, stiff and painful neck in hypertension

Precautions  :

Dosage  : 9 to 15 g.

Storage  : Preserve in a ventilated dry place, protected from moth.

Synonymns for Pueraria lobata

Patent Medicines and Medicines with Multiple Ingredients that include Pueraria lobata

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Pueraria lobata in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Qiang Yang, Chengliang Luo, Xinmu Zhang, Yuancai Liu, Zufeng Wang, Piergiacomo Cacciamani, Jiao Shi, Yongchun Cui, Chunling Wang, Bharati Sinha, Bin Peng, Guoqiang Tong, Gapika Das, Elisha Shah, Yuan Gao, Wei Li, Yanyang Tu, Dongyang Qian, Khalid Shah, Mohammed Akbar, Shuanhu Zhou, Byoung-Joon Song, Xin Wang
Tartary buckwheat extract alleviates alcohol-induced acute and chronic liver injuries through the inhibition of oxidative stress and mitochondrial cell death pathway.
Am J Transl Res: 2020, 12(1);70-89
[PubMed:32051738] [WorldCat.org] (P e)

Bashir Ahmad, Suliman Khan, Yang Liu, Mengzhou Xue, Ghulam Nabi, Sunjeet Kumar, Mohammed Alshwmi, Abdul Wakeel Qarluq
Molecular Mechanisms of Anticancer Activities of Puerarin.
Cancer Manag Res: 2020, 12;79-90
[PubMed:32021425] [WorldCat.org] [DOI] (P e)

Qian Feng, Song-Yi Cheng, Rui Yang, Xiang-Wei Zeng, Feng-Ming Zhao, Xiu-Qin Zhan
Puerarin promotes the viability and differentiation of MC3T3-E1 cells by enhancing LC3B-mediated autophagy through downregulation of miR-204.
Exp Ther Med: 2020, 19(2);883-890
[PubMed:32010248] [WorldCat.org] [DOI] (P p)

Yong-Deok Jeon, Ji-Hyun Lee, Young-Mi Lee, Dae-Ki Kim
Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model.
Biomed. Pharmacother.: 2020, 124;109847
[PubMed:31981944] [WorldCat.org] [DOI] (I p)

Chong Peng, Zun-Ming Zhou, Jing Li, Yan Luo, Yun-Song Zhou, Xue-Hong Ke, Ke-Er Huang
##Title##
Evid Based Complement Alternat Med: 2019, 2019;5941263
[PubMed:31976000] [WorldCat.org] [DOI] (P e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects