Psoralea corylifolia

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Other Names:

Historical Use of Psoralea corylifolia

Psoralea corylifolia in Traditional Chinese Medicine


Poguzhi ÆƹÊÖ½ Chinese Name (pinyin): Buguzhi

Chinese Name  :

Common Name  :Psoralea Fruit

Specific Name  : Fructus psoraleae

Scientific Name:
Collection  : The infructescence is collected in autumn when the fruit is ripe, dried in the sun. The fruit is gathered and remove from foreign matter.

Description  : Reniform, 3 - 5mm long, 2 - 4mm wide about 1.5mm thick. Externally black, blackish brown or greyish brown with fine reticulate wrinkles. Apex obtuse-rounded with a small prominence and the depressed end showing a scar of fruit stalk. Texture hard, pericarp thin, uneasily stripped from seed, 1 seed, cotyledons 2, yellowish white, oily, odor aromatic, taste pungent and slightly bitter.

Identification  : To 0.5g of the powder add 20ml of ethyl acetate, ultrasonicate for 15 minutes, filter. Evaporate the filtrate to dryness, dissolve the residue in 1ml of ethyl acetate as the test solution. Dissolve psoralen CRS and isopsoralen CRS in ethyl acetate to produce a solution containing 2mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and n-hexane (8:2) as the mobile phase. Apply separately to the plate 2 - 4µl of each of the two solutions. After developing and removal of the plate, dry it in the air, spray with a 10% solution of potassium hydroxide in methanol and examine under ultra violet light (365nm). The two bluish white fluorescent spot in the chromatogram obtained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matter.Processed with salt: stir fry as described under the method for stir frying with salt (Appendix ll D) until slightly inflated.

Action  : To invigorate the function of kidney, to alleviate asthma, and to relieve diarrhea.

Indication  : impotence, seminal emission; enuresis, frequent urination; aching of the loins and knees with cold sensation; asthma in deficiency syndromes of the kidney; diarrhea occuring daily before dawn external: vitiligo, alopecia areata

Precautions  :

Dosage  : 6 to 9 g; for external use, tincture of Fructus Psoraleae of 20% - 30% in concentration to be applied topically.

Storage  : Preserve in a dry place.

Synonymns for Psoralea corylifolia

Patent Medicines and Medicines with Multiple Ingredients that include Psoralea corylifolia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Psoralea corylifolia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Cao-Sang Truong, Eunhui Seo, Hee-Sook Jun
Oxid Med Cell Longev: 2019, 2019;4310319
[PubMed:31976027] [] [DOI] (I e)

Anna Xiao-Dan Yu, Miranda Li Xu, Ping Yao, Kenneth Kin-Leung Kwan, Yong-Xiang Liu, Ran Duan, Tina Ting-Xia Dong, Robert Kam-Ming Ko, Karl Wah-Keung Tsim
Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways.
FASEB J.: 2020;
[PubMed:31965654] [] [DOI] (I a)

Xiaoxue Wu, Xuemin Gao, Xinmei Liu, Shuyi Zhang, Huayu Yang, Xuan Zhu, Hua Song, Funan Li, Qing Chen
Molecules: 2020, 25(2);
[PubMed:31936676] [] [DOI] (I e)

Hu-Qiang He, Betty Yuen Kwan Law, Ni Zhang, Cong-Ling Qiu, Yuan-Qing Qu, An-Guo Wu, Yu Han, Qi Song, Wen-Lu Zheng, Yong Liu, Yan-Zheng He, Vincent Kam Wai Wong
Front Pharmacol: 2019, 10;1427
[PubMed:31920640] [] [DOI] (P e)

Ya-Lei Liu, Fei-Lin Ge, Jing-Xiao Zhu, Jing Jing, Jia-Bo Wang, Ya-Ming Zhang, Yu-Ming Guo, Xiao-He Xiao
[Re-evaluation of liver injury associated with Buguzhi Preparations based on passive monitoring data and hospital cases].
Zhongguo Zhong Yao Za Zhi: 2019, 44(19);4272-4276
[PubMed:31872709] [] [DOI] (P p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects