Polygala sibirica

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Other Names:

Historical Use of Polygala sibirica

Polygala sibirica in Traditional Chinese Medicine


Chaoyuanzhi ³´Ô¶Ö¾ Yuanzhirou Ô¶Ö¾Èâ Chinese Name (pinyin): Yuanzhi

Chinese Name  :

Common Name  :Polygala Root

Specific Name  : Radix polygalae

Scientific Name:
Collection  : The drug is collected in spring and autumn, removed from rootlet and soil and dried in the sun.

Description  : Cylindrical somewhat curved. 3 - 15 cm long, 3 - 8 mm in diameter. Externally greyish yellow to greyish brown with dense and dented transverse wrinkles, longitudinal wrinkles and fissures, old roots with denser and deeply dented transverse wrinkles, somewhat nodular. Texture hard and fragile, uneasily broken, fracture brownish yellow in bark. Yellowish white in wood. Bark easily separating from wood. Odour slight, taste bitter and slightly pungent with an irritative sensation in the throat on chewing.

Identification  : 1.Transverse section: Cork of 10 or more rows of cells. Cortex of 20 or more rows of parenchymatous cells, tangentially cleft. Phloem relatively broad, usually radial clefted. Cambium in a ring. Xylem well develop, all lignified, rays 1 -3 rows of cells wide. Parenchymatous cells mostly containing fixed oil drops, some containing clusters and prisms of calcium oxalate.2.Place about 0.5g of the powder into a stoppered test tube. Add 10 ml of hot water. Keep the temperature for 10 minutes and shake vigorously for 1 minute. A persistent foam is produced, persisting for at least 10 minutes.Total ash: Not more than 6.0%

Processing  : Eliminate foreign matter, wash briefly, soften thoroughly, cut into sections and dry.Radix Polygalae (prepared): Decoct Radix Glycyrrhizae with a quantity of water, remove the residue. Add clean Radix Polygalae, decoct gently until the liquid is exhausted and dry , using 6 kg of Radix Glycyrrhizae for 100 kg of Radix Polygalae.

Action  : To induce sedation and benefit the mentality, to promote expectoration, and to cause subsidence of swelling.

Indication  : insomnia, dream-disturbed sleep, forgetfulness, palpitation, trance; cough with sputum difficult to expectorate; boils and sores, swelling and pain in the breast

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a ventilated dry place.

Synonymns for Polygala sibirica

Patent Medicines and Medicines with Multiple Ingredients that include Polygala sibirica

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Polygala sibirica in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Hui Zeng, Piaopiao Li, Lishuang Zhou, Kan Ding
Int. J. Biol. Macromol.: 2020;
[PubMed:32473218] [WorldCat.org] [DOI] (I a)

Shuoqi Chen, Jianping Jia
Tenuifolin Attenuates Amyloid-β42-Induced Neuroinflammation in Microglia Through the NF-κB Signaling Pathway.
J. Alzheimers Dis.: 2020;
[PubMed:32444542] [WorldCat.org] [DOI] (I a)

Xinxin Deng, Shipeng Zhao, Xinqi Liu, Lu Han, Ruizhou Wang, Huifeng Hao, Yanna Jiao, Shuyan Han, Changcai Bai
Pharm Biol: 2020, 58(1);410-416
[PubMed:32429787] [WorldCat.org] [DOI] (I p)

Xiao-Juan Ren, Guan-Ying Wang, Xing-Ping Zhang, Qing-Quan Wang, Zhi-Peng Peng
Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats.
Chin J Integr Med: 2020;
[PubMed:32240473] [WorldCat.org] [DOI] (I a)

Wei Xie, Hade Wulin, Guo Shao, Liqin Wei, Ruifang Qi, Baohui Ma, Naihong Chen, Ruili Shi
Polygalasaponin F inhibits neuronal apoptosis induced by oxygen-glucose deprivation and reoxygenation through the PI3K/Akt pathway.
Basic Clin. Pharmacol. Toxicol.: 2020;
[PubMed:32237267] [WorldCat.org] [DOI] (I a)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects