Phellodendron amurense

Background

Chinese Name (pinyin): Huangbo

Chinese Name  :

Common Name  :Bark of Chinese Corktree

Specific Name  : Cortex phellodendri

Scientific Name:
Collection  : The drug is collected, removed from coarse bark and dried in the sun.

Description  : Chuan Huangbo, tabular or shallowly channeled, varying in length and width, 3-6mm thick, outer surface yellowish brown, even or longitudinally furrowed, some showing scars of lenticels and remains of greyish coarse bark, inner surface dark yellow or pale brown with fine longitudinal ridges. Texture light and hard, fracture fibrous showing lobelike layes, dark yellow, odour slight, taste very bitter, viscous after chewing.Guan Huangbo: 2-4mm thick, outer surface yellowish green or pale brownish yellow, relatively even with irregular longitudinal fissures, scars of lenticels small and infrequently visible, occasionally remaining greyish-white coarse bark. Inner surface yellow or yellowish brown, texture light and relatively hard, fracture bright yellow or yellowish green.

Identification  : 1.Powder: Greenish yellow or yellow, fibres bright yellow, 16-38µm in diameter, often in bundles, sorounded by parenchymatous cells containing prisms of calcium oxalate forming crystal fibres, the walls of crystal cells lignified and thickened. Stone cells bright yellow, subrounded or fusiform, 35-128µm in diameter, some branched sharp at the top, walls thickened with striations distinct. Prisms of calcium oxalate up to 24µm in diameter.2.To 1g of the powder, add 10ml of ether, shake well, filter and evaporate the filtrate to dryness. Dissolve the residue in 1ml of glacial acetic acid, add 1 drop of sulfuric acid and allow to stand, a purplish brown colour is produced..3.Heat under reflux 0.1g of the powder with 5ml of methanol for 15 minutes on a water bath and filter. To the filtrate add methanol to produce a 5ml solution as the test solution of cortex Phellodendri reference drug in the same manner as the reference drug solution. Dissolve berberin hydrochloride CRS in methanol to produced a solution containing 0.5mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and benzene-ethylacetate-isopropanol-concentrated ammonia TS (6:3:1:5:0.5) as the mobile phase. Apply separately to the plate 1µl of each of the three solutions. After developing and removal of the plate, dry it in the air and examine under ultra violet light (365nm). The fluorescent spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference drug solution. The yellow fluorescent spot in the chromatogram obtained with the test solution correspond in the position and colour to the spot in the chromatogram obtained with the reference solution.

Processing  : Eliminate foreign matter, spray with water, soften thoroughly, cut into slivers and dry.Processed with salt: Stir fry the slivers as describe under the method of stir frying with salt water (Appendix ll D) to dryness.Carbonized: Stir fry the slivers as describe under the method of carbonizing by stir frying (appendix ll D) until the surface becomes charred black.

Action  : To remove damp-heat, quench fire, counteract toxicity, and relieve consumptive fever. Cortex Phellodendri (processed with salt): To nourish yin and reduce fire.

Indication  :

Precautions  :

Dosage  : 3 to 12 g; appropraite quantity for external use.

Storage  : Preserve in a ventilated and dry place, protected from moisture.

Evidence or the Use of Phellodendron amurense in the Treatment of Epilepesy

1st Five Results: pubmed search

Tian Zhang, Jiexin Wang, Yi Wang, Linxi He, Shangbin Lv, Yiran Wang, Weihong Li
Wenyang-Tianjing-Jieyu Decoction Improves Depression Rats of Kidney Yang Deficiency Pattern by Regulating T Cell Homeostasis and Inflammation Level.
Neuropsychiatr Dis Treat: 2024, 20;631-647
[PubMed:38545129] [WorldCat.org] [DOI] (P e)

Ying Hao, Bingcheng Wang, Yuan Feng, Xiaodong Xin, Yawei Deng, Mingsong Liu, Chunhua Li, Shiqiao Liu, Qingqing Zhang
Metabolic profile of Phellodendron amurense Rupr. in vivo of rat and its metabolomic study on intervention in rheumatoid arthritis.
J Pharm Biomed Anal: 2024, 243;116064
[PubMed:38492509] [WorldCat.org] [DOI] (I p)

Subhajit Hazra, Preet Amol Singh, Neha Bajwa
Safety Issues of Herb-Warfarin Interactions.
Curr Drug Metab: 2024;
[PubMed:38465436] [WorldCat.org] [DOI] (I a)

Wanran Zhang, Ranran Gao, Lixia Tian, Zhichao Xu
##Title##
Front Plant Sci: 2024, 15;1363063
[PubMed:38450408] [WorldCat.org] [DOI] (P e)

Hongyun Xu, Chunyu Wu, Danning Wang, Haiqiang Wang
Alleviating effect of Nexrutine on mucosal inflammation in mice with ulcerative colitis: Involvement of the RELA suppression.
Immun Inflamm Dis: 2024, 12(1);e1147
[PubMed:38270298] [WorldCat.org] [DOI] (I p)