Nigella glandulifera

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Other Names:

Historical Use of Nigella glandulifera

Nigella glandulifera in Traditional Chinese Medicine


Chinese Name (pinyin): Heizhongcaozi

Chinese Name  :

Common Name  :Fennelflower Seed

Specific Name  : Semen nigellae

Scientific Name:
Collection  :

Description  : Triangular-ovoid, 2.5-3mm long, about 1.5mm wide. Externally black and rough, apex somewhat narrow and sharp; base relatively obtuse, with irregular protrudings. Texture hard; fracture greyish-white, oily. Odour, slightly aromatic; taste, pungent.

Identification  : ransverse section: Epidermis cells of testa 1 row, varying in size, sub-rectangular or irregular oblong, frequently elongated tangentially, outer walls mostly with papilla-like or non-glandular hair like excrescences, thin finely and densely granulate striations indistinctly visible. Parenchyma of testa consisting of 3 - 4 rows of cells, rectangular or irregular, somewhat elongated tangentially, inner epidermis cells 1 row, flattened, brown. Parisperm consisting of 1 row of rectangular cells, elongated radial, sometimes dilapidated, endosperm cells polygonal, filled with oil droplets and aleurone grains. Cotyledon cells polygonal or sub-rounded, the outer row of cells slightly elongated radially, filled with aleurone grains and fatty oil droplets.Powder: Greyish black, epidermal cells of testa dark brown, polygonal on surface view, varying in size, the outer walls gibbose or mammillate, the inner epidermis of testa, brown, rectangular or sub-polygonal on surface view, anticlinal walls beaded, periclinal walls finely and densely reticulate striated. Endosperm cells polygonal containing oil droplets and aleurone grains.

Processing  :

Action  : To replenish the kidney and benefit the brain, to stimulate menstruation, to promote the flow of milk, and to induce diuresis.

Indication  : tinnitus and forgetfulness; amenorrhea; inadequate secretion of milk; urinary tract infecion, urolithiasis

Precautions  : Contraindicated in pregnancy and in patients with febrile diseases.

Dosage  : 2 to 6 g.

Storage  : Preserve in a cool and dry place.

Synonymns for Nigella glandulifera

Patent Medicines and Medicines with Multiple Ingredients that include Nigella glandulifera

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Nigella glandulifera in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
Extracts of compound Muniziqi granule suppressed uterus contraction and ameliorated oxytocin-induced primary dysmenorrhea.
J Ethnopharmacol: 2018, 223;33-40
[PubMed:29783015] [] [DOI] (I p)

Jun-Bo Gao, Xing-Jie Zhang, Rui-Han Zhang, Li-Li Zhu, De-Bing Pu, Xiao-Li Li, Hong-Lin Li, Min Xu, Wei-Lie Xiao
In Vitro Human Dihydroorotate Dehydrogenase Inhibitory, Anti-inflammatory and Cytotoxic Activities of Alkaloids from the Seeds of Nigella glandulifera.
Planta Med.: 2018, 84(14);1013-1021
[PubMed:29621808] [] [DOI] (I p)

Jie Tian, Chao Han, Wen-Hua Guo, Yong Yin, Xiao-Bing Wang, Hong-Bin Sun, He-Quan Yao, Yong Yang, Chen Wang, Chang Liu, Ming-Hua Yang, Ling-Yi Kong
Nigegladines A-C, Three Thymoquinone Dimers from Nigella glandulifera.
Org. Lett.: 2017, 19(23);6348-6351
[PubMed:29148797] [] [DOI] (I p)

Dilinuer Maimaitiyiming, Mayila Kamilijiang, Xiadiya Xiaerfuding, Shi Wen Hui, Meiliwan Abudureyimu, - Hajinisha, Ainiwaer Aikemu
Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice.
Pak J Pharm Sci: 2017, 30(5);1567-1571
[PubMed:29084674] [] (P p)

Dan Tang, Qi-Bin Chen, Xue-Lei Xin, Haji-Akber Aisa
Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway.
Biomed. Pharmacother.: 2017, 87;145-152
[PubMed:28049096] [] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects