Myristica fragrans

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Other Names:

Historical Use of Myristica fragrans

Myristica fragrans in Traditional Chinese Medicine


Rouguo Èâ¹û Weirouguo ìÐÈâ¹û Yuguo Óñ¹û Chinese Name (pinyin): Roudoukou

Chinese Name  :

Common Name  :Nutmeg

Specific Name  : Semen myristicae

Scientific Name:
Collection  :

Description  : Ovoid or ellipsoidal, 2-3 cm long, 1.5-2.5 cm in diameter. Externally greyish-yellow, sometimes covered with white powder (lime powder). Pale longitudinal furrows and irregular reticulated wrinkles occurred all over the seed. A hilum occurring at the broad end, showing a pale colored, rounded convex. Chalaza dark and dented. Raphe longitudinally furrowed, connecting with two ends. Texture hard, Fracture showing marble-like striations, brownish-yellow, inter-weaved. A dried and shrunken embryo visible at the broad end, oily. Odour, strongly aromatic; taste, pungent.

Identification  : 1.Transverse section: Outer layers of perisperm consisting of more than 10 rows of flattened and wrinkled cells, containing brown contents, small prisms visible occasionally, crisscross tissue with small vascular bundles, dark brown perisperm inserting to the pale yellow endosperm forming marble like striations with numerous oil cells. Cells of endosperm thin walled, sub-rounded, filled with starch granules, fatty oil droplets and aleurone grains scattered with pale yellow cells. Starch granules mostly simple, 10 - 20 µm in diameter. Occasionally compound composed of 2 - 6 components, 25 - 30µm in diameter, hilum distinct. After treating with iodine solution and mounting in glycerin, examine immediately under a microscope, the relatively large aleurone grains visible among numerous bluish black starch granules. If mount in charcoal hydrate, the fatty oil often showing piece shape or scale shape and turning to oil droplets while heating.2.To the volatile oil obtained from the assay, add chloroform to produce a solution containing 0.2ml of volatile oil per ml as the test solution. Prepare a solution of Semen Myristicae reference drug in the same manner as the reference drug solution. Carry out the method for thin layer chromatography (Appendix VL B), using silica gel G as the coating substance and petroleum ether (60 - 90ºC) benzene (1:1) as the mobile phase. Apply separately to the plate 10µl of each of the two solutions. After developing and removal of the plate, dry it in the air, spray with anisaldehyde TS. Heat at 105ºC for several minutes. The spots in the chromatogram obtained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference drug solution.Water: Carry out the method for determination of water (Appendix lX H, method 1) not more than 10.0%.Assay: Weigh accurately 20g of the coarse powder, carry out the method for determination of volatile oil (Appendix X D). It contains not less than 6.0% (ml/g) of the volatile oil.

Processing  : Eliminate foreign matters, wash clean and dry.Stir fried with gentle heat: To each clean Semen Myristicae, wrap in a mixture of wheat flour and a quantity of water or carry out the method of making water pills, moisten the surface of Semen Mysristicae with water, wrap in 3 - 4 layers of wheat flour. Stir fry the wrapped drug with heated talc powder or sand until the wheat flour cover showing charred yellow, sift, strip off the cover and cool, using 50kg of talc powder per 100 kg of Semen Mysristicae.

Action  : To warm the spleen and stomach and promote the flow of qi, to arrest diarrhea as an astringent.

Indication  : defieciency-cold of the spleen and stomach with persisten diarrhea, epigastric and abdominal distension and pain, anorexia, and vomiting

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a cool and dry place, protected from moth.

Synonymns for Myristica fragrans

Patent Medicines and Medicines with Multiple Ingredients that include Myristica fragrans

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Myristica fragrans in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Mohamed A Ibrahim, Charles L Cantrell, Ekaterina A Jeliazkova, Tess Astatkie, Valtcho D Zheljazkov
Molecules: 2020, 25(3);
[PubMed:32012955] [] [DOI] (I e)

Saleh Al-Quraishy, Mohamed A Dkhil, Rewaida Abdel-Gaber, Rafat Zrieq, Taghreed A Hafez, Murad A Mubaraki, Ahmed E Abdel Moneim
Myristica fragrans seed extract reverses scopolamine-induced cortical injury via stimulation of HO-1 expression in male rats.
Environ Sci Pollut Res Int: 2020;
[PubMed:31993909] [] [DOI] (I a)

Desidério Duarte, Marta Mendonça, Luís Ramos
[The Psychoactive Power of Foods: A Case of Acute Nutmeg Intoxication]. [O Poder Psicoativo dos Alimentos: Análise de um Caso de Intoxicação com Noz-Moscada.]
Acta Med Port: 2019;
[PubMed:31962059] [] [DOI] (I a)

Zélie Triaux, Hugues Petitjean, Eric Marchioni, Maria Boltoeva, Christophe Marcic
Deep eutectic solvent-based headspace single-drop microextraction for the quantification of terpenes in spices.
Anal Bioanal Chem: 2020, 412(4);933-948
[PubMed:31927601] [] [DOI] (I p)

Inga Matulyte, Aiste Jekabsone, Lina Jankauskaite, Paulina Zavistanaviciute, Vytaute Sakiene, Elena Bartkiene, Modestas Ruzauskas, Dalia M Kopustinskiene, Antonello Santini, Jurga Bernatoniene
Foods: 2020, 9(1);
[PubMed:31906495] [] [DOI] (P e)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects