Morphia

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Morphia is a non-scientific common name that may refer to a number of plant species and varieties.

Nomenclature

Other Names:

Historical Use of Morphia

Morphia in Traditional Chinese Medicine

Description

Historical Use of Morphia in Western Medicine

Quote Paraph: [WRITTEN UNDER THE SUBSECTION OF "OPIUM" IN THE CHAPTER ON TREATMENT] "In the "status epilepticus," in which attacks recur with great frequency for several days, and in which bromide often fails entirely, I have known hypodermic injections of morphia, in doses of1/16th of a grain, to be of great service, and Sieveking has found it useful, given by the mouth, in the same state. But morphia is a remedy which can only be employed hypodermically in epileptics with extreme caution. If an attack occurs, and the post-epileptic coma coincides with the sleep induced by morphia, the patient's life is in great danger. For instance, an epileptic, after a surgical operation, was injected with a quarter of a grain of morphia to relieve great pain. As the injection was beginning to take effect, he had a slight epileptic fit, and immediately passed into a condition of profound coma, with infrequent breathing, and it was necessary to maintain artificial respiration for an hour."
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Primary Source: Gowers, WR. Epilepsy and other chronic convulsive diseases. New York. William Wood & Company. 1885.

Background

Synonymns for Morphia

Patent Medicines and Medicines with Multiple Ingredients that include Morphia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Morphia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Lily H Kim, Jonathon J Parker, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern, Brenda Porter, Gerald A Grant
Postoperative outcomes following pediatric intracranial electrode monitoring: A case for stereoelectroencephalography (SEEG).
Epilepsy Behav: 2020, 104(Pt A);106905
[PubMed:32028127] [WorldCat.org] [DOI] (I a)

Yu-Chi Wang, Sanjeet S Grewal, Anshit Goyal, Mohammed Ali Alvi, Gregory Worrell, Benjamin Brinkmann, Lily Wong-Kisiel, Jeffrey Britton, W Richard Marsh, David Burkholder, Eric Payne, Cheolsu Shin, Gregory Cascino, Brian N Lundstrom, Min-Hsien Wu, Jamie J Van Gompel
Comparison of narcotic pain control between stereotactic electrocorticography and subdural grid implantation.
Epilepsy Behav: 2020, 103(Pt A);106843
[PubMed:31882325] [WorldCat.org] [DOI] (I p)

Paul Cumming, János Marton, Tuomas O Lilius, Dag Erlend Olberg, Axel Rominger
A Survey of Molecular Imaging of Opioid Receptors.
Molecules: 2019, 24(22);
[PubMed:31752279] [WorldCat.org] [DOI] (I e)

Sonja Lj Joksimovic, Srdjan M Joksimovic, Francesca M Manzella, Betelehem Asnake, Peihan Orestes, Yogendra H Raol, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic
Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain.
Br. J. Pharmacol.: 2019;
[PubMed:31732978] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects