Momordica cochinchinensis

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Other Names:

Historical Use of Momordica cochinchinensis

Momordica cochinchinensis in Traditional Chinese Medicine


Chinese Name (pinyin): Mubiezi

Chinese Name  :

Common Name  :Cochinchina Momordica Seed

Specific Name  : Semen momordicae

Scientific Name:
Collection  : The ripe fruit is collected in winter, cut and a half dried in the sun. The removed from the pulp and dried.

Description  : Flattened plate like, slightly raised or dented in the center,2 - 4cm in diameter about thick. Externally greyish brown to blackish brown with reticulated pattern and a yellowish hilum at the relatively larger dentate protruding the in the margin. Tetsta hard and brittle, endotesta greyish green, tomentous like. 2 cotyledons, yellowish white, oily. Odor characteristically greasy and taste bitter.

Identification  : 1. Powder: Yellowish-grey. Sclerenchymatous cells elliptical or sub-rounded, sinuous-margined, 51-117µm in diameter, with thickened and lignified walls, and lumina distinct and some narrowed. Parenchymatous cells of cotyledons polygonal, containing fixed oil masses and aleurone grains; fixed oil masses sub-rounded, 27-73µm in diameter, reticulated striations visible on the surface.2. To 2g of the coarse powder add 20ml of ether macerate warmly for 30 minutes and filter. Place 2ml of the ether extract into a glass dish, evaporate to dryness. To the residue add a small quantity of anhydrous sodium sulfate, heat, bubbles and thick white irritating gas are produced. 3. To 2g of the coarse powder add 20ml of water, heat on a water bath for 30 minutes, filter. Place 2ml of the filtrate into a stoppered test tube, shake vigorously for 1 minute, a large amount of foam is produced, which persists for 10 minutes.

Processing  : Semen Momordicae: Remove the shell and break the kernel to pieces.

Action  : To promote the subsidence of nodulation and swelling, combat poisons and cure sores.

Indication  : sores and inflammatory swelling, mastitis, scrofula, hemorrhoids, anal fistula, chronic eczema, neurodermatitis,scald

Precautions  :

Dosage  : 0.9 to 1.2 g for oral administration; appropriate quantity to be ground into powder and mixed with oil or vinegar for topical application.

Storage  : Preserve in a dry place.

Synonymns for Momordica cochinchinensis

Patent Medicines and Medicines with Multiple Ingredients that include Momordica cochinchinensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Momordica cochinchinensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Xiao-Rong Xu, Chuan-Hong Luo, Bo Cao, Run-Chun Xu, Fang Wang, Xi-Chuan Wei, Ting Zhang, Li Han, Ding-Kun Zhang
A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen.
Molecules: 2019, 24(21);
[PubMed:31683690] [] [DOI] (I e)

Mengyue Wang, Zhibin Zhan, Ying Xiong, Ying Zhang, Xiaobo Li
Cytotoxic and anti-inflammatory constituents from Momordica cochinchinensis seeds.
Fitoterapia: 2019, 139;104360
[PubMed:31629869] [] [DOI] (I p)

Peter M Jones, Elizabeth Mazzio, Karam Soliman, Anthony M George
In Silico Investigation of the Binding of MCoTI-II Plant Defense Knottin to the γ-NGF Serine Protease of the 7S Nerve Growth Factor Complex and Biological Activity of Its NGF Mimetic Properties.
J Phys Chem B: 2019, 123(43);9104-9110
[PubMed:31580077] [] [DOI] (I p)

Hung-Tse Huang, Yu-Chi Lin, Li-Jie Zhang, Chia-Ching Liaw, Hsin-Yen Chen, Ming-Tung Hsueh, Yao-Haur Kuo
Nat. Prod. Res.: 2019;1-8
[PubMed:31533481] [] [DOI] (I a)

Hanh Phan-Thi, Yves Waché
Behind the Myth of the Fruit of Heaven, a Critical Review on Gac (Momordica cochinchinensis Spreng.) Contribution to Nutrition.
Curr. Med. Chem.: 2019, 26(24);4585-4605
[PubMed:31284852] [] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects