Ligusticum chuanxiong

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Nomenclature

Other Names:

Historical Use of Ligusticum chuanxiong

Ligusticum chuanxiong in Traditional Chinese Medicine

Background

Fuxiong ¸§Üº Chinese Name (pinyin): Chuanxiong

Chinese Name  :

Common Name  :Chuanxiong Rhizome

Specific Name  : Rhizoma chuanxiong

Scientific Name:
Collection  : The drug is collected in summer when the node of stem becomes obviously swollen and purplish, removed from soil, baked gently to dryness after sundried and removed from rootlet.

Description  : In irregualar knotty and fish like masses, 2 - 7 cm in diameter. Externally yellowish brown, rough and shrunken with many parallel and raised annulations showing dent and subrounded stem scars on the summit and numerous tuberculous rootlet scars beneath the summit and at the annulations., texture compact, uneasily broken, fracture yellowish white or greyish yellow, scattered with yellowish brown oil cavities. Cambium in an andulate ring. Odour strongly aromatic, taste bitter, pungent and slight numb but sweetish afterwards.

Identification  : 1.Transverse section: Cork consisting of over 10 layer of cells. Cortex narrow, scattered with root trace vascular bundles, interfascicular camnium distinct. Phloem broad, cambium undulate or irregularly polygonal. Vessels in xylem polygonal or sub rounded, mostly uniseriate or arrange in V shape, wood fibres in bundles occasionally found. Parenchymatous scattered with numerous oil cavities, sub rounded, elliptical or irregular, pale yellowish brown, smaller near the cambium and gradually becoming large outwards. Parenchymatous cells containing abundant starch granules. Some with crystal of calcium oxalate, sub rounded or clustered like.Powder: Pale yellowish brown or greyish brown, starch granules abundant, single granules ellipsoidal oblong, sub spheroidal, ovoid or reniform, 5 - 16 µm in diameter. About 21 µm long, hilum pointed, slit shaped or V shaped. Compoun granules occasionally found, consisting of 2 - 4 components. Crystal of calcium oxalate occurring in parenchymatous cells in sub rounded masses or clustered crystal like, 10 - 25 µm in diameter. Cork cells dark yellowish brown, frequently overlapped in many layers, polygonal in surface view, thin walled. Oil cavities mostly broken, fragments occasionally founnd, secretory cells thin walled containing many oil drops. Vessels mainly spiral and reticulate scalariform as well, 14 - 50 µm in diameter, the thickened walls of some spiral vessels connected to form reticulate like vessels.2.Macerate 1 g of the fine powder in 5 ml of petroleum ether (30 - 60ºC), shake constantly and allow to stand for 10 hours. Evaporate 1 ml of the supernatant to dryness and dissolve the residue in 1 ml of methanol. Add 2 - 3 drops of 2% solution of 3.5-dinitrobenzoic acid methanol and 2 drops of saturated solution of potassium hydroxide in methanol, a purplish red colour is produced.To 1 g of the powder add 20 ml of ether, heat under reflux for 1 hour, filter and evaporate the filtrate to dryness. Dissolve the residue in 2 ml of ethyl acetate as the test solution. Prepare a solution of Rhizoma Chuanxiong reference drug in the same manner as the reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and n-hexane-ethyl acetate (9:1) as the mobile phase. Apply separately to the plate 1 - 2 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and examine under ultra violet light (365 nm). The fluorescence spots in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference drug solution.Total ash: Not more than 6.0%

Processing  : Eliminate foreign matter, grade according to size, soak briefly, wash briefly clean, soften thoroughly, cut into thin slices and dry.

Action  : To promote the flow of blood and qi, dispel wind and relieve pain.

Indication  :

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a ventilated and dry place, protected from moth.

Synonymns for Ligusticum chuanxiong

Patent Medicines and Medicines with Multiple Ingredients that include Ligusticum chuanxiong

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Ligusticum chuanxiong in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Yun Luo, Chong-Zhi Wang, Richard Sawadogo, Ting Tan, Chun-Su Yuan
Effects of Herbal Medicines on Pain Management.
Am. J. Chin. Med.: 2020, 48(1);1-16
[PubMed:32054304] [WorldCat.org] [DOI] (I p)

Yu-Mei Cao, Da-Le Guo, Meng-Ying Jin, Lu Tan, Tian-Long Yang, Fang Deng, Yu-Cheng Gu, Xiao-Hua Li, Zhi-Xing Cao, Yun Deng
##Title##
Nat. Prod. Res.: 2020;1-5
[PubMed:31979990] [WorldCat.org] [DOI] (I a)

Jie Zhang, Yunyao Jiang, Nan Liu, Ting Shen, Hyo Won Jung, Jianxun Liu, Bing Chun Yan
A Network-Based Method for Mechanistic Investigation and Neuroprotective Effect on Post-treatment of Senkyunolid-H Against Cerebral Ischemic Stroke in Mouse.
Front Neurol: 2019, 10;1299
[PubMed:31920923] [WorldCat.org] [DOI] (P e)

Yanfei Liu, Weiliang Weng, Rui Gao, Yue Liu
New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach.
Oxid Med Cell Longev: 2019, 2019;4598167
[PubMed:31915506] [WorldCat.org] [DOI] (I e)

Jianxiu Zhai, Zhaohui Ren, Yuwei Wang, Mingshu Han, Na Han, Zhihui Liu, Sikai Li, Jun Yin
Traditional Chinese patent medicine Zhixiong Capsule (ZXC) alleviated formed atherosclerotic plaque in rat thoracic artery and the mechanism investigation including blood-dissolved-component-based network pharmacology analysis and biochemical validation.
J Ethnopharmacol: 2019;112523
[PubMed:31884033] [WorldCat.org] [DOI] (I a)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects