Laminaria japonica

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P272 2.jpg
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Other Names:

Historical Use of Laminaria japonica

Laminaria japonica in Traditional Chinese Medicine


Dankunbu µ­À¥²¼ Chinese Name (pinyin): Kunbu

Chinese Name  :

Common Name  :Laminaria

Specific Name  : Thallus laminariae

Scientific Name:
Collection  : The drug is collected in summer and autumn and dried in the sun

Description  : Thallus Laminariae: Rolled and folded into a mass or winded up into a bundle. Blackish brown or greenish brown throughout, eternally showing white frost like powder. After soaking in water, swollen into long flattened strap. 50 -150 cm long, 10 - 40 cm wide relatively thick in central part, thinner and undulate on edges. Slightly coriaceous, remains of stripe compressed cylindrical, odour seaweed like and taste salty.Thallus Eckloniae: Rolled and crumpled into an irregular ball. Black throughout, relatively thin. After soaking in water, swellen into flattened phylloid, 16 - 26 cm long and wide, about 1.6 mm thick, two sides pinnaatiparte, lobes long ligulate, margins serrulate or entire. Texture soft and smooth.

Identification  : 1.Thick, swollen on soaking in water, surface smooth and viscous with transparent mucilage. When twisted with fingers, Thallus Laminariae can not be laminated and Thallus Eckloniae laminated.2.Macerate about 10 g of small pieces in 200 ml of water for several hours, filter and concentrate the filtrate to about 100 ml. To 2 - 3 ml of the concentrated solution, add 1 drop of nitric acid and several drops of silver nitrate TS, a yellow colloidal precipitatre is produced which is slightly soluble in ammonia TS but insoluble in nitric acid.Assay: Weigh accurately 10 g of small pieces to a crucible, ignite gently and keep for 10 minutes whenever the temperature is raised for 100ºC and keep for 40 minutes at 400 - 500ºC. Allow to cool and place the residue in a beaker. Add 100 ml of water, boil for about 5 minutes and filter. Treat the residue with further 2 quantities of 100 ml of water, filter, combine the filtrates, wash the residue with 3 quantities of hot water, combine the washings and the filtrate and concentrate to about 80 ml. Allow to cool. Transfer to a 100 ml volumetric flask and dilute with water to volume. Transfer accurately 5 ml to a glass stopper flask. Add 50 ml of water and 2 drops of methyl red IS, add dropwise. Dilute sulfuric acid solution until a red color is produced. Add 5 ml of freshly prepared bromine TS, heat to boil, add 5 ml of 20% sodium formate solution along the flask wall and heat for 10 - 15 minutes again. Wash the flask wall with hot water, cool, add 5 ml of dilute sulfuric acid solution and 5 ml of 15% solution of potassium iodide, titrate immediately with sodium thiosulfate (0.01 mol/L) VS to pale yellow, add 1 ml of starch IS and continue to titrate until the blue color disappears. Each ml of sodium thiosulfate (0.01 mol/L) VS is equivalent to 0.2115 mg of I.Thallus laminariae contains not less than 0.35% of I; Thallus Eckloniae contains not less than 0.20% of I, calculated on dried basis.

Processing  : Eliminate foreign matter, rinse, briefly dry in the air, cut into wide slivers and dry in the sun.

Action  : To eliminate phlegm, soften hard masses abd dissolve lumps, and to cause diuresis.

Indication  : goiter, scrofula, swelling and pain in the testis; edema

Precautions  :

Dosage  : 6 to 12 g.

Storage  : Preserve in a dry place.

Synonymns for Laminaria japonica

Patent Medicines and Medicines with Multiple Ingredients that include Laminaria japonica

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Laminaria japonica in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Justin T Diedrich, Eleanor A Drey, Sara J Newmann
Cervical preparation for dilation and evacuation at 20-24 weeks' gestation.
Contraception: 2020;
[PubMed:32007418] [] [DOI] (I a)

Wen-Jing Hsu, Mei-Hsiang Lin, Tai-Chih Kuo, Chih-Ming Chou, Fwu-Long Mi, Chia-Hsiung Cheng, Cheng-Wei Lin
Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells.
Int. J. Biol. Macromol.: 2020, 149;600-608
[PubMed:32004612] [] [DOI] (I a)

Dong Han, Heng-Lin Cui
Int. J. Syst. Evol. Microbiol.: 2020;
[PubMed:31971500] [] [DOI] (I a)

Mohamed M Abdel-Daim, Abdelrahman Ibrahim Abushouk, Eshak I Bahbah, Simona G Bungău, Mohamed S Alyousif, Lotfi Aleya, Saad Alkahtani
Fucoidan protects against subacute diazinon-induced oxidative damage in cardiac, hepatic, and renal tissues.
Environ Sci Pollut Res Int: 2020;
[PubMed:31965500] [] [DOI] (I a)

Xue-Ying Li, Hao-Ran Chen, Xue-Qiang Zha, Shun Chen, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo
Prevention and possible mechanism of a purified Laminaria japonica polysaccharide on adriamycin-induced acute kidney injury in mice.
Int. J. Biol. Macromol.: 2020, 148;591-600
[PubMed:31958563] [] [DOI] (I a)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects