Hyoscyamus niger
Contents
Nomenclature
Other Names:
Historical Use of Hyoscyamus niger
Hyoscyamus niger in Traditional Chinese Medicine
Background
Chinese Name (pinyin): Tianxianzi
Chinese Name :
Common Name :Henbane Seed
Specific Name : Semen hyoscyami
Scientific Name:
Collection : The fruit is collected in summer and autumn when the pericarp turns yellow, expose to the sun and seed is tapped out, removed from pericarp and branch and dried in the sun
Description : Flattened subreniform or flattened ovoid, about 1 mm in diameter. Externally brownish yellow or greyish yellow with fine reticulated striations and a pointed hilum at somewhat acute end. Section greyish white oily having endesperm, embryo curved. Odorless, taste slightly pungent.
Identification : 1.To 0.5g of the powder add 0.5ml of concentrated ammonia TS, mix well, add 5ml of chloroform, stopper tightly, shake constantly for 0.5 hour and filter. Evaporate the filtrate to dryness, dissolve the residue in 0.5ml of chloroform. Evaporate 5 drops of the solution on a water bath to dryness, add 4 drops of fuming nitric acid, evaporate to dryness. To the residue add 1ml of dehydrated ethanol and a small piece of potassium hydroxide, a purple color is produced.2.To 1g of the powder add 10 ml of petroleum ether (30 - 60ºC), ultrasonicate for 15 minutes, discard the petroleum ether solution, treat the residue in the same manner once again. Evaporate the residue to dryness, moisten with 2 ml of a mix solution of equal amount of concentrated ammonia TS and ethanol, add 20 ml of chloroform, ultrasonicate for 15 minutes, filter. Evaporate the filtrate to dryness, dissolve the residue in 0.5ml of dehydrated ethanol as the test solution. Dissolve atropine sulfate CRS and scopolamine hydrobromide CRS in dehydrated ethanol to produce solution containing 1 mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and ethyl acetate-methanol-concentrated ammonia TS (17:2:1) as the mobile phase. Apply separately to the plate 5 µl of each two solutions. After developing and removal of the plate, dry it in the air. Spray with potassium iodobismuthate TS ethanolic sodium nitrite TS successively. The two brown spots in the chromatogram obtained with the test solution correspond in position and color to the spot in the chromatogram obtained with the reference solution.
Processing :
Action : To relieve spasm and pain, and to cause tranquilization.
Indication : gastric spasm and pain; asthma, cough; mania
Precautions : Contraindicated in heart diseases, tachycardia, glauoma nd pregnancy.
Dosage : 0.06 to 0.6 g.
Storage : Preserve in a ventilated and dry place.
Synonymns for Hyoscyamus niger
Patent Medicines and Medicines with Multiple Ingredients that include Hyoscyamus niger
Pharmaceutical Information
Chemical Constituents
Evidence or the Use of Hyoscyamus niger in the Treatment of Epilepesy
Basic Science
Animal Studies
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
Meta-Analysis
1st Five Results: pubmed search
Morteza Kosari, Farzin Khorvash, Mohammad Kazem Sayyah, Maryam Ansari Chaharsoughi, Ahmad Najafi, Mansooreh Momen-Heravi, Mohammad Karimian, Hossein Akbari, Mehdi Noureddini, Mahmoud Salami, Amir Ghaderi, Javad Amini Mahabadi, Seyed Peyman Khamechi, Somayeh Yeganeh, Hamid Reza Banafshe
The influence of propolis plus Hyoscyamus niger L. against COVID-19: A phase II, multicenter, placebo-controlled, randomized trial.
Phytother Res: 2024, 38(1);400-410
[PubMed:37992760]
[WorldCat.org]
[DOI]
(I p)
Diletta Piatti, Riccardo Marconi, Simone Angeloni, Giovanni Caprioli, Filippo Maggi, Emanuele Ribatti, Vittorio Cattaneo, Gianni Sagratini
##Title##
Nat Prod Res: 2023;1-6
[PubMed:37830795]
[WorldCat.org]
[DOI]
(I a)
Sara Pourhabibian, Alireza Iranbakhsh, Mostafa Ebadi, Halimeh Hassanpour, Azadeh Hekmat
Alteration in the callogenesis, tropane alkaloid formation, and gene expression in Hyoscyamus niger under clinorotation.
Protoplasma: 2024, 261(2);293-302
[PubMed:37814140]
[WorldCat.org]
[DOI]
(I p)
Sabrina Lekmine, Ouided Benslama, Kenza Kadi, Antonio Ignacio Martín-García, Mustafa Abdullah Yilmaz, Salah Akkal, Ali Boumegoura, Abdullah S Alhomida, Mohammad Shamsul Ola, Ahmad Ali
##Title##
Pharmaceuticals (Basel): 2023, 16(7);
[PubMed:37513927]
[WorldCat.org]
[DOI]
(P e)
Aisha M Abdelkawy, Shifaa O Alshammari, Hebat-Allah A Hussein, Inas M M Abou El-Enain, Eman S Abdelkhalek, Asmaa M Radwan, Sahar K M Kenawy, Doaa A M Maaty, Nermine N Abed, Shadia Sabry, Abeer Mohsen
Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity.
Sci Rep: 2023, 13(1);10397
[PubMed:37369701]
[WorldCat.org]
[DOI]
(I e)
