Gardenia jasminoides

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P298 2.jpg

Nomenclature

Other Names:

Historical Use of Gardenia jasminoides

Gardenia jasminoides in Traditional Chinese Medicine

Background

Chaozhizi ³´èÙ×Ó Heishanzi ºÚɽèÙ Jiangzhizi ½ªèÙ×Ó Shengshanzhi ÉúɽèÙ Shengzhizi ÉúèÙ×Ó Zhizipi èÙ×ÓƤ Zhiziren èÙ×ÓÈÊ Zhizitan èÙ×ÓÌ¿ Chinese Name (pinyin): Zhizi

Chinese Name  :

Common Name  :Capejasmine Fruit

Specific Name  : Fructus gardeniae

Scientific Name:
Collection  : The drug is collected from September to November when it turns reddish yellow, remove from the fruit stalk and foreign matter, steam thoroughly or treated with boiling water for a moment then dried.

Description  : Prolate ovoid or ellipsoid, 1.5 - 3.5cm long, 1 - 1.5cm in diameter. The outer surface reddish yellow or brownish red with 6 longitudinal winged ribs and a conspicious longitudinal and branched vein between two ribs. Summit bearing remains of sepals, base somewhat tapering and having a remain of fruit stalk. Pericarp thin and brittle, somewhat lustrous, the inner surface relatively pale in color, lustrous with 2 - 3 raised false septa. Seeds numerous, flattened ovoid, aggregated into a mass, deep red or reddish yellow with fine and dense warts on the surface. Odor slight, taste slightly sour and bitter.

Identification  : 1.Powder: reddish brown, stone cells pericarp subrectangular, fibres of pericarp long and thin, fusiform, about 10µm in diameter up to 110µm long, obliquely mosaicarranged. Crystal stone cells subrounded or polygonal, 17 - 31µm in diameter with thickened walls, lumina containing prisms of calcium oxalate about 8µm in diameter. Stone cells of testa yellow or pale-brown, elongated polygonal, rectangular or irregular in shape, 60 - 112µm in diameter up to 230µm long with large pitted and thickened walls and brownish red lumina. Clusters of calcium oxalate 19 - 34µm in diameter.2.Heat 0.2g of the powder in 5ml of water on a water bath for 3 minutes and filter. Evaporate 5 drops of filtrate to dryhness in an evaporating dish. To the residue add 1 drop of sulfuric acid, a bluish green color is produced which turn to brown rapidly then to a purplish brown colour.3.Macerate 1g of the powder in 10ml of 75% ethanol on a warm water bath for 2 hours, filter and use the filtrate as the test solution. Dissolve jasminoidin CRS in ethanol to produce a solution containing 4mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silca gel G as the coating substance and ethyl- acetate- acetone- formic acid- water (5:5:1:1) as the mobile phase. Apply bseparately to nthe plate 5µl of each of the two solutions. After developing and removal of the plate, dry it in the air. Spray with sulfuric acid solution (5?10) in ethanol, heat at 110ºC for about 10 minutes. The spots in the chromatogram ontained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference solutionTotal ash: Not more than 6.0%

Processing  :

Action  : To reduce fire and ease the mind, to eliminate damp-heat, and to remove heat from blood and counteract toxicity. Fructus Gardeniae (charred): to arrest bleeding by removing heat from blood.

Indication  : febrile diseases with restlessness; jaundice with dark urine; hamaturia with difficult painful urination; hemoptysis and epistaxis caused by heat in the blood; inflammation of the eye; boils and sores external: sprains and bruises charred: hemoptysis, epistaxis, hematuria and abnormal uterine bleeding caused by heat in the blood

Precautions  :

Dosage  : 6 to 9 g; for external use, appropritae quantity of unprocessed fruit to be ground into powder and applies topically after mixed with a liquid.

Storage  : Preserve in a ventilated and dry place.

P298 2.jpg

Nomenclature

Other Names:

Historical Use of Gardenia jasminoides

Gardenia jasminoides in Traditional Chinese Medicine

Background

Chaozhizi ³´èÙ×Ó Heishanzi ºÚɽèÙ Jiangzhizi ½ªèÙ×Ó Shengshanzhi ÉúɽèÙ Shengzhizi ÉúèÙ×Ó Zhizipi èÙ×ÓƤ Zhiziren èÙ×ÓÈÊ Zhizitan èÙ×ÓÌ¿ Chinese Name (pinyin): Zhizi

Chinese Name  :

Common Name  :Capejasmine Fruit

Specific Name  : Fructus gardeniae

Scientific Name:
Collection  : The drug is collected from September to November when it turns reddish yellow, remove from the fruit stalk and foreign matter, steam thoroughly or treated with boiling water for a moment then dried.

Description  : Prolate ovoid or ellipsoid, 1.5 - 3.5cm long, 1 - 1.5cm in diameter. The outer surface reddish yellow or brownish red with 6 longitudinal winged ribs and a conspicious longitudinal and branched vein between two ribs. Summit bearing remains of sepals, base somewhat tapering and having a remain of fruit stalk. Pericarp thin and brittle, somewhat lustrous, the inner surface relatively pale in color, lustrous with 2 - 3 raised false septa. Seeds numerous, flattened ovoid, aggregated into a mass, deep red or reddish yellow with fine and dense warts on the surface. Odor slight, taste slightly sour and bitter.

Identification  : 1.Powder: reddish brown, stone cells pericarp subrectangular, fibres of pericarp long and thin, fusiform, about 10µm in diameter up to 110µm long, obliquely mosaicarranged. Crystal stone cells subrounded or polygonal, 17 - 31µm in diameter with thickened walls, lumina containing prisms of calcium oxalate about 8µm in diameter. Stone cells of testa yellow or pale-brown, elongated polygonal, rectangular or irregular in shape, 60 - 112µm in diameter up to 230µm long with large pitted and thickened walls and brownish red lumina. Clusters of calcium oxalate 19 - 34µm in diameter.2.Heat 0.2g of the powder in 5ml of water on a water bath for 3 minutes and filter. Evaporate 5 drops of filtrate to dryhness in an evaporating dish. To the residue add 1 drop of sulfuric acid, a bluish green color is produced which turn to brown rapidly then to a purplish brown colour.3.Macerate 1g of the powder in 10ml of 75% ethanol on a warm water bath for 2 hours, filter and use the filtrate as the test solution. Dissolve jasminoidin CRS in ethanol to produce a solution containing 4mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silca gel G as the coating substance and ethyl- acetate- acetone- formic acid- water (5:5:1:1) as the mobile phase. Apply bseparately to nthe plate 5µl of each of the two solutions. After developing and removal of the plate, dry it in the air. Spray with sulfuric acid solution (5?10) in ethanol, heat at 110ºC for about 10 minutes. The spots in the chromatogram ontained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference solutionTotal ash: Not more than 6.0%

Processing  :

Action  : To reduce fire and ease the mind, to eliminate damp-heat, and to remove heat from blood and counteract toxicity. Fructus Gardeniae (charred): to arrest bleeding by removing heat from blood.

Indication  : febrile diseases with restlessness; jaundice with dark urine; hamaturia with difficult painful urination; hemoptysis and epistaxis caused by heat in the blood; inflammation of the eye; boils and sores external: sprains and bruises charred: hemoptysis, epistaxis, hematuria and abnormal uterine bleeding caused by heat in the blood

Precautions  :

Dosage  : 6 to 9 g; for external use, appropritae quantity of unprocessed fruit to be ground into powder and applies topically after mixed with a liquid.

Storage  : Preserve in a ventilated and dry place.

Synonymns for Gardenia jasminoides

Patent Medicines and Medicines with Multiple Ingredients that include Gardenia jasminoides

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Gardenia jasminoides in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Zhuo Chen, Weiming Liu, Zhigang Qin, Xiaoting Liang, Gengren Tian
Geniposide exhibits anticancer activity to medulloblastoma cells by downregulating microRNA-373.
J. Biochem. Mol. Toxicol.: 2020;e22471
[PubMed:32057176] [WorldCat.org] [DOI] (I a)

Shanshan Guo, Lei Bao, Chun Li, Jing Sun, Ronghua Zhao, Xiaolan Cui
Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication.
Sci Rep: 2020, 10(1);1897
[PubMed:32024921] [WorldCat.org] [DOI] (I e)

Li Cai, Yu-Rong Mu, Ming-Ming Liu, Wen-Jian Tang, Rong Li
Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis.
Int. Immunopharmacol.: 2020, 80;106182
[PubMed:31981962] [WorldCat.org] [DOI] (I a)

Xiaoqiao Tang, Yangfeng Wang, Wenxiang Yang, Yanhua Zheng, Chunxia Liu, Min Qu, Haibin Xu, Lei Zhang, Jiang Liang, Bolin Fan
Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats.
Int J Environ Res Public Health: 2020, 17(2);
[PubMed:31947699] [WorldCat.org] [DOI] (I e)

Hyo In Kim, Se Hyang Hong, Jin Mo Ku, Min Jeong Kim, Sung Wan Ju, Seok Won Chang, Chunhoo Cheon, Seong-Gyu Ko
##Title##
Nutrients: 2020, 12(1);
[PubMed:31936835] [WorldCat.org] [DOI] (I e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects