Fritillaria ussuriensis

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Nomenclature

Other Names:

Historical Use of Fritillaria ussuriensis

Fritillaria ussuriensis in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Pingbeimu

Chinese Name  :

Common Name  :Ussuri Fritillary Bulb

Specific Name  : Bulbus Fritillariae Ussuriensis

Scientific Name:
Collection  : The drug is collected in spring, removed from outer bark, fibrous root and soil, dried in the sun or at low temperature.

Description  : Oblate, 0.5-1 high, 0.6-2cm in diameter, externally milk white or plate yellowish white or pale yellowish white, outer scale leaves 2, uniform in size or the large scale leaf embracing the small one, apex slightly flat or concave, frequently slightly split, scales in the center small. Texture: hard and fragile, fracture starchy. Odor slightly, Taste: bitter.

Identification  : 1.Powder: starch granules simple, rounded triangular, ovoid, rounded-conchoidal, triangularovoid, long-cocooned, 6-58 (-74) µm in diameter up to 67µm long, hilum cleft like, pointed or V shaped in the smaller end, striation dense and distinct. Semi-compound few, hilum 2, simple granules with multihilum visible occasionally, hilum 2-4. Stomata subrounded or depressed rounded. 40-48 (50)µm in diameter with 4-6 subsidiary cells.2.Macerate 2g of the powder in 20ml of water on a water bath at 60ºC for 10 minutes, filter immediately, shake vigorously, 2ml of the filtrate in a stoppered test tube for 1 minute, foam is produced, standing persisting over 10 minutes.3.Heat under reflux 5g of the powder in 35ml of 0.5% solution of hydrochloric acid in ethanol on a water bath for 10 minutes, filter while hot. 15ml of the filtrate add 5% ammonia solution to neutralize, evaporate to dryness on a water bath. Dissolve the residue in 3ml of 5% sulfuric acid solution and filterr. Transfer the filtrate to three test tubes respectively. For the first test tube add 2 drops of silicotungstic acid TS, a greyish-white precipitate is produced, to the second tube add 2 drops of potassium iodobismuthate TS, a reddish-brown precipitate is produced, to the last tube add mercuric potassium iodide TS, a white precipitate is produced.4.5g of the powder add 2ml of the concentrated ammonia TS, 20ml of chloroform, stir well, allow to stand over night and filter. Evaporate the filtrate to dryness, dissolve the residue in 0.4ml of chloroform as the test solution. Prepare a solution of Bulbus Fritillariae Ussuriensis reference drug in the same manner as the reference drug solution and dissolve peimine CRS and peiminine CRS in the chloroform to produced a solution containing 0.5mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G prepared with 0.5% sodium hydroxide solution as coating substance and the lower layer of chloroform-ethyl acetate-methanol-water (30:40:20:10) standing below 10ºC as the mobile phase. Apply separately to the plate 4-6µl of each of the three solutions. After developing and removal of the plate, dry it in the air. Spray with potassium iodobismuthate TS and ethanolic sodium nitrite TS successively. The spots in the chromatogram obtained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference drug solution. The two brown spots in the chromatogram obtained with the test solution correspond in the position and color to the spots in the chromatogram obtained with the reference solution.

Processing  :

Action  : To remove heat from the lung, relieve cough and resolve phlegm.

Indication  : heat in the lung with cough, sticky and bloody sputum, and distress in the chest

Precautions  : Incompatible with Radix Aconit and allied drugs.

Dosage  : 3 to 9 g; or 1 to 2 g as one dose, to be ground into powder and taken after pouring liquid on it.

Storage  : Preserve in a ventilated dry place, protected from moth.

Synonymns for Fritillaria ussuriensis

Patent Medicines and Medicines with Multiple Ingredients that include Fritillaria ussuriensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Fritillaria ussuriensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Qi Chen, Xiaobo Wu, Dequan Zhang
Comparison of the abilities of universal, super, and specific DNA barcodes to discriminate among the original species of Fritillariae cirrhosae bulbus and its adulterants.
PLoS ONE: 2020, 15(2);e0229181
[PubMed:32053689] [WorldCat.org] [DOI] (I e)

Man Zhang, Hong Zhao, Yu Shen, Yuliang Wang, Zhimeng Zhao, Yu Zhang
Preparation, characterization and antioxidant activity evaluation in vitro of Fritillaria ussuriensis polysaccharide-zinc complex.
Int. J. Biol. Macromol.: 2020, 146;462-474
[PubMed:31923487] [WorldCat.org] [DOI] (I p)

Yingchun Zhong, Haiying Wang, Qianhe Wei, Rui Cao, Hailong Zhang, Yongzhi He, Lizhi Wang
Combining DNA Barcoding and HPLC Fingerprints to Trace Species of an Important Traditional Chinese Medicine Fritillariae Bulbus.
Molecules: 2019, 24(18);
[PubMed:31500338] [WorldCat.org] [DOI] (I e)

Zhibin Wang, Feng Cao, Yajun Chen, Zhenqiu Tang, Zhenyue Wang
##Title##
Molecules: 2018, 23(7);
[PubMed:29958456] [WorldCat.org] [DOI] (I e)

A B Cunningham, J A Brinckmann, S-J Pei, P Luo, U Schippmann, X Long, Y-F Bi
High altitude species, high profits: Can the trade in wild harvested Fritillaria cirrhosa (Liliaceae) be sustained?
J Ethnopharmacol: 2018, 223;142-151
[PubMed:29751123] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects