Fritillaria thunbergii

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Nomenclature

Other Names:

Historical Use of Fritillaria thunbergii

Fritillaria thunbergii in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Zhebeimu

Chinese Name  :

Common Name  :Thunberg Fritillary Bulb

Specific Name  : Bulbus of Fritillariae thunbergii

Scientific Name:
Collection  :

Description  : Dabei: the outer single scale leaf of bulb, almost in crescent shape, 1-2cm high, 2-3cm in diameter, The outer surface whitish to pale yellow, the inner surface with white or pale brown, covered with white powder. Texture: hard and fragile, easily broken, fracture white to yellowish white, highly starchy. Odor: slight, Taste: slightly bitter.Zhubei: whole bulb, oblate, 1-1.5cm high, 1-2.5cm in diameter, externally whitish, the outer scale leaves 2, plump and fleshy, almost in reniform holding to each other, containing 2-3 scale leaves and dried shrunken stem remains. Zhebeipian: slices cut from the outer single scale leaf of bulb, eliptical or subrounded, 1-2cm in diameter, surface of edge pale yellow, cut surface even, powdery white. Texture: hard and fragile, easily broken, fracture powdery white, highly starchy.

Identification  : 1.Powder: pale yellowish white, starch granules, numerous, simple granules ovoid, broad ovoid or eliptic 6-56µm in diameter, hilum pointed, cleft like V shaped in the smaller end, striation mostly distinct, semi compound and compound granules composed of two components visible occasionally. Epidermis cells subpolygonal or rectangular, anticlinal walls beaded. Stomata sometimes visible with 4-5 subsidiary cells. Crystals of calcium oxalate minute mostly granular, some in fusiform square or thin bacilliform. Vessels mostly spiral up to 18µm in diameter.2.Add 2-3 drops of iodine TS to the transverse section, a bluish-purple color with edge in whitish develops.3.Heat under reflux, 1g of coarse powder with 20ml of 70% ethanol for about 30 minutes, filter and evaporate to dryness. Dissolve the residue in 5ml of 1% solution of hydrochloric acid, filter and transfer the filtrate to two test tubes respectively. To 1 tube add 3 drops of potassium iodobismuthate TS an orange precipitate is produced. To another tube add 1-3 drops of silicotungstic acid TS, a white flocculent precipitate is produced.4.Examine the powder under ultra-violet light (365nm) a pale green fluorescence is shown.5.To 5g of the powder, add 2ml of concentrated ammonia solution and 20ml of benzene, allow to stand over night, filter and evaporate 8ml of the filtrate to dryness. Dissolve the residue in 1ml of chloroform as the test solution. Dissolve peiimine CRS and peiminine CRS in chloroform to produce a solution containing 2mg of each per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G containing sodium carboxymethylcellulose as the coating substance and ethyl acetate-methanol-concentrated ammonia solution (17:2:1) as the mobile phase. Apply separately to the plate 10-20µm of the test solution and 10µl of the reference solution. After developing and removal of the plate, dry it in the air, spray with dilute potassium iodobismuthate TS. The spots in the chlromatogram obtained with the test solution correspond in the position and color with the spots in the chromatogram obtained with reference solution.

Processing  : eliminate foreighn matter, wash clean, soften thoroughly, cut into thick slices and dry or pound to pieces.

Action  : To remove heat and resolve phlegm, to ease th emind, and to reduce nodulation.

Indication  : cough caused by wind-heat, dryness-heat or phlegm-heat; lung abscess; mastitis; scrofula; depression

Precautions  : Incompatible with Radix Aconiti and allied drugs.

Dosage  : 4.5 to 9 g.

Storage  : Preserve in a dry place, protected from the moth.

Synonymns for Fritillaria thunbergii

Patent Medicines and Medicines with Multiple Ingredients that include Fritillaria thunbergii

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Fritillaria thunbergii in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Minjee Kim, Dinh-Van Nguyen, Yoonki Heo, Ki Hoon Park, Hyun-Dong Paik, Young Bong Kim
##Title##
J. Microbiol. Biotechnol.: 2019;
[PubMed:31752057] [WorldCat.org] [DOI] (I a)

Yingchun Zhong, Haiying Wang, Qianhe Wei, Rui Cao, Hailong Zhang, Yongzhi He, Lizhi Wang
Combining DNA Barcoding and HPLC Fingerprints to Trace Species of an Important Traditional Chinese Medicine Fritillariae Bulbus.
Molecules: 2019, 24(18);
[PubMed:31500338] [WorldCat.org] [DOI] (I e)

Jian-Ming Jiang, Xin-Guang Yu, Wen-Jing Wang, Zhong-Hua Wang, Jiang-Wei Shao, Zhi-An Wang
[Breeding and variety characteristics of a new variety of Fritillaria thunbergii "Zhebei 3"].
Zhongguo Zhong Yao Za Zhi: 2019, 44(3);448-453
[PubMed:30989906] [WorldCat.org] [DOI] (P p)

Boxian Zhao, Chen Shen, Zhixing Zheng, Xiaoxiong Wang, Wenyang Zhao, Xin Chen, Fei Peng, Linmeng Xue, Mengting Shu, Xu Hou, Kaikai Wang, Chen Zhong, Jingxian Sun, Jinzhao Wan, Shiguang Zhao
Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking.
Cell. Physiol. Biochem.: 2018, 51(4);1566-1583
[PubMed:30497066] [WorldCat.org] [DOI] (I p)

Zhibin Wang, Feng Cao, Yajun Chen, Zhenqiu Tang, Zhenyue Wang
##Title##
Molecules: 2018, 23(7);
[PubMed:29958456] [WorldCat.org] [DOI] (I e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects