Forsythia suspensa

Background

Lianqiaoke Á¬ÇÌ¿Ç Lianqioaxin Á¬ÇÌÐÄ Qinglianqiao ÇàÁ¬ÇÌ Chinese Name (pinyin): Lianqiao

Chinese Name  :

Common Name  :Forsythia Fruit

Specific Name  : Fructus forsythiae

Scientific Name:
Collection  : The drug is collected in autumn when nearly ripe and still greenish, remove from foreign matter, steam thoroughly and dried in the sun (known as "Qingqiao") or the drug is collected when fully ripe, dried and remove from foreign matter (known as "Laoqiao")

Description  : Long ovoid to ovoid, slightly compressed, 1.5 - 2.5cm long, 0.5 - 1.3cm in diameter. Externally, with irregular longitudinal wrinkles. Numerous raised small maculaters and longitudinal furrow on each of the two surfaces. Apex acute, bearing a small fruit stalk or its scar at the base, Qingqiao mostly indehiscent, externally greenish brown with less small greyish white maculates, texture hard, seeds numerous, yellowish green, slender winged at one side. Laoqiao dehiscent from apex or to two segments, outer surface yellowish brown or reddish brown, inner surface mostly pale yellowish brown, smooth with longitudinal septum. Texture brittle, seeds brown, mostly fallen off. Odor slightly aromatic and taste bitter.

Identification  : 1.Transverse section of perticarp: exocarp consisting of 1 row of epidermal cells with thickened outer and lateral walls covered with cuticle. Mesocarp composed of vascular bundles scattered in parenchyma at the outer side and many layers of stone cells at the inner side, elongated subrounded or oblong, wall thickness variable mostly tagentially parqueted and extended to the cells of the septum, endocarp consisting of 1 layer parenchymatous cells.2.Extract 1g of the powder in a Soxhlet's extractor with ether until the liquid becomes colorless. Transfer ether to a separating funnel, wash the ether with three 15ml portions of 5% sodium carbonate solution, discard the washings. Extract the ether with three 20ml portions of 1% sodium hydroxide, acidity the combined solution of sodium hydroxide with dilute hydrochloric acid and extract with three 20ml portions of ether. Evaporate the combined ether to dryness, dissolve the residue in 1ml ethanol and use it as the test solution. Prepare a solution of Fructus forsythiae reference drug in same way as the reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silca gel G as the coating substance and cyclohexane-chloroform-benzene-methanol (5:3:5:1) as the mobile phase. Apply separately 5µl of each of the above two soltuions to the plate. After developing and removal of the plate, dry it in the air, spray with 5% ferric chloride solution acidified with hydrochloric acid, dry with hot blowing until the color of the spots appear clearly. The spots in the chromatogram obtained with the test solution correspond in position and color to the spots in the chromatogram obtained with the reference drug solution.Foreign matter: not more than 3% for green Fructus Forsythiae(Qingqiao), not more than 9% for brown Fructus forsythiae (Laoqiao) Appendix lX K).Total ash: not more than 4% (Appendix lX K)Extractives: carry out the method for determination of extracives, cold maceration method (Appendix X A) using 65% ethanol as the solvent not less than 30.0% for Qingqiao not less than 16.0% for Laoqiao.

Processing  :

Action  : To remove toxic heat, to cause subsidence of swelling, and to eliminate nodulation.

Indication  : carbuncles, boils, lymphadenitis, mastitis, erysipelas; upper respiratory tract infection; febrile diseases at the early stage and at the stage of high fever, intense thirst, delirium and maculation; acute urinary tract infection with oliguria

Precautions  :

Dosage  : 6 to 15 g.

Storage  : Preserve in a dry place.

Evidence or the Use of Forsythia suspensa in the Treatment of Epilepesy

1st Five Results: pubmed search

Yue Mu, Bo Liu, Xuan Zhang, Ye Zhang, Jie Wei, Xiao-Qing Wang, Yu-Wu Chen, Xiao-Lan Cui, Ying-Ni Pan, Yi Sun
[Analysis of constituents in different parts of Forsythia suspensa by UPLC-Q-TOF-MS and evaluation of their anti-inflammatory activity].
Zhongguo Zhong Yao Za Zhi: 2024, 49(4);968-980
[PubMed:38621904] [WorldCat.org] [DOI] (P p)

X Guo, Z Guo, D Sun, L Zou, J Ou, L Yu, Z Lu, H Cao, J Liu
[Single extract of Forsythia Suspense versus the prepared drug in pieces: comparison of their anti-inflammatory, antitumor and antibacterial effects in zebrafish].
Nan Fang Yi Ke Da Xue Xue Bao: 2024, 44(3);594-604
[PubMed:38597452] [WorldCat.org] [DOI] (P p)

Guocui Liang, Chengxia Gao, Liwei Zhang, Huizhi Du
##Title##
Nat Prod Res: 2024;1-5
[PubMed:38529756] [WorldCat.org] [DOI] (I a)

Chenyu Zhou, Quan Xia, Hamizah Shahirah Hamezah, Zheng Fan, Xiaohui Tong, Rongchun Han
##Title##
Front Pharmacol: 2024, 15;1288584
[PubMed:38500762] [WorldCat.org] [DOI] (P e)

Hisashi Kato-Noguchi, Yuga Takahashi, Shunya Tojo, Toshiaki Teruya
##Title##
Plants (Basel): 2024, 13(5);
[PubMed:38475422] [WorldCat.org] [DOI] (P e)