Epimedium koreanum

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Other Names:

Historical Use of Epimedium koreanum

Epimedium koreanum in Traditional Chinese Medicine


Xianlingpi ÏÉÁéÆ¢ Chinese Name (pinyin): Yinyanghuo

Chinese Name  :

Common Name  :Epimedium

Specific Name  : Herba epimedii

Scientific Name:
Collection  : The drug is collected in summer and autumn when foliage branch growing luxuriantly, remove from the thick stalks and foreign matter and dried in the sun or in the shade.

Description  :

Identification  : To 0.5g of the powder, add 10ml of the ethanol, macerate warmly for 30 minutes, filter, evaporate the filtrate to dryness. Dissolve the residue in 1ml of ethanol as the test solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica H containing 0.5% of sodium carboxymethylcellulose as the coating substance and ethyl acetate-butanone-formic acid-water (10:1:1:1) as the mobile phase. Apply 10µl of each of the test solution and the reference solution obtained under assay to the plate. After developing and removal of the plate, dry it in the air and examine under ultra violet light (365nm). The dark red fluorescence spot in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference solution. Spray with aluminum chloride TS, examine again under ultra violet light (365nm), the spot turn to orange red.Assay: Standard Preparation weigh accurately 10mg of icariin CRS previously dried to constant weight at 105ºC, dissolve and dilute with methanol to volume in a 20ml volumetric flask, mix well as the reference solution (containing 0.5mg of icariin per ml)Preparation standard curve: Transfer accurately 5ml of the reference preparation to a 100ml volumetric flask, add methanol to volume and mix well. Dilute, 0.0, 1.0, 2.0, 3.0, 5.0, 7.0, 9.0ml of the resulting solution to 10ml volumetric flasks separately. Add methanol to volumn and mix well. Measure the absorbance at 270nm (appendix VA), plot a standard curve with absorbance as ordinate and concentration as abscissa.Test preparation : T about 0.5g of the leaves in coarse powder, previously dried at 80ºC for 4 hours and accurately weighed, add 20ml of 70% ethanol, accurately measured in a round bottom flask, weigh and heat under reflux for 1 hour, allow to cool and weigh again, make up the loss in weight with 70% ethanol, shake thoroughly and filter. Discard the initial filtrate, collect the successive filtrate as the test preparationProcedure: Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and ethyl acetate-butanone-formic acid-water (5:3:1:1) as the mobile phase. Apply 100µl, accurately measured of the test preparation to the plate in strip and 10µl of reference preparation in spot 1.5cm beside the strip. After developing and removal of the plate, dry it in the air. Examine under ultra violet light (365nm). Scrape off and collect the strip of silica gel G showing dark red fluorescence corresponding in position to icariin in a 10ml test tube, scrape off the equal area of silica gel G from same plate and collect in another 10ml test tube as blank. Add 10ml, accurately measured of the methanol to each test tube, shake thoroughly, allow to stand for 2 hours and filter. Discard the initial filtrate and collect the successive filtrate. Measure the absorbance of the resulting solution at 270nm (Appendix V A). read out the weight (µg) of icariin in the test preparation from the standard curve and calculate the content of C33 H40 O15. The leaves previously dried at 80ºC for 4 hours contains not less then 1.0% of icariin (C33H40O15).

Processing  : Eliminate foreign matter, pick the leaves, spray with water, soften slightly, cut into slivers and dry.Herba Epimedii (processed): stir fry slivers with refined suet by gently heating until an even lustre is produced, remove and let cool. Using 20kg of refined suet per 100kg of herba epimedii.

Action  :

Indication  : impotence, seminal emission, weakness of the limbs; rheumatic or rheumatoid arthralgia with numbness and muscle contracture; climacteric hypertension

Precautions  :

Dosage  : 6-10g

Storage  :

Synonymns for Epimedium koreanum

Patent Medicines and Medicines with Multiple Ingredients that include Epimedium koreanum

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Epimedium koreanum in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Xin-Guang Sun, Ming Zhou, Bai-Ping Ma, Bao-Lin Guo
[Change of icariin content in five Epimedium species by heating process].
Zhongguo Zhong Yao Za Zhi: 2019, 44(9);1857-1861
[PubMed:31342713] [WorldCat.org] [DOI] (P p)

Jae-Yong Kim, Sang Hee Shim
Nutrients: 2019, 11(5);
[PubMed:31109081] [WorldCat.org] [DOI] (I e)

Huaran Zhang, Xuewei Wu, Jinxia Wang, Miaomiao Wang, Xiaoning Wang, Tao Shen, Shuqi Wang, Dongmei Ren
Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities.
Nat. Prod. Res.: 2019;1-8
[PubMed:30663372] [WorldCat.org] [DOI] (I a)

Hong Min Choi, Jeong Yoon Kim, Zuo Peng Li, Janar Jenis, Yeong Jun Ban, Aizhamal Baiseitova, Ki Hun Park
Molecules: 2019, 24(2);
[PubMed:30654565] [WorldCat.org] [DOI] (I e)

Yan-Dan Zhou, Jin-Gang Hou, Ge Yang, Shuang Jiang, Chen Chen, Zi Wang, Ying-Ying Liu, Shen Ren, Wei Li
Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway.
Biomed. Pharmacother.: 2019, 109;2309-2317
[PubMed:30551489] [WorldCat.org] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects