- 1 Nomenclature
- 2 Historical Use of Dipsacus japonicus
- 3 Background
- 4 Pharmaceutical Information
- 5 Evidence or the Use of Dipsacus japonicus in the Treatment of Epilepesy
- 6 Safety
Historical Use of Dipsacus japonicus
Dipsacus japonicus in Traditional Chinese Medicine
Chinese Name (pinyin): Xuduan
Chinese Name :
Common Name :Dipsacus Root
Specific Name : Radix dipsaci
Collection : The drug is collected in autumn, removed from root stock and rootlet, baked to half dry, piled up until green colour is developed inside and then baked to dryness.
Description : Cylindrical, somewhat flattened, some slightly curved, 5 - 15 cm long, 0.5 - 2 cm in diameter. Externally greyish brown or yellowish brown with slightly twisted longitudinal wrinkles and furrows, showing transversal lenticels and sparse rootlet scars. Texture soft and hardened after long storage, easily broken, fracture uneven, bark dark green or brown, the outer part brown or pale brown, wood yellowish brown, vessels bundle arranged radially. Odour slightly aromatic, taste bitter, slightly sweet then astringent.
Identification : 1.Transverse section: Cork consisting of several layers of cells. Cortex narrow. Groups of sieve tubes sparsely scattered in phloem. Cambium ring distinct or less distinct. Xylem ray broad, vessels dense near the cambium and lessened inward often singly scattered or 2 - 4 grouped. Pith small and mostly absent in small roots. Parenchymatous cells containing clusters of calcium oxalate.Powder: Yellowish brown, clusters of calcium oxalate fairly abundant, 15 - 50 µm in diameter, scattered through out or embedded in shrunken parenchymatous cells. Sometimes several clusters arranged in dense slat shape. The walls of fusiform parenchymatous cells slightly thickened with fine oblique crisscross striations. Bordered pits and reticulated vessels up to 72 (-90) µm in diameter. Cork cells pale brown, subrectangul;ar, subsquare polygonal or long polygonal in surface view with thin walls.2.To 5 g of the powder add 2 ml of ammonia TS, stir well then add 50 ml of chloroform. Heat under reflux for 1 hour and filter. Add 10 ml of hydrochloric acid solution (1Õ100) to the filtrate, shake well. Separate the acid solution, make alkaline with ammonia TS, add 10 ml ofchloroform and shake well. Separate the chloroform solution, add 5 ml of hydrochloric acid solution (1Õ100) and shake well. Transfer the acid solution into three test tubes respectively, to the first test tube add potassium iodobismuthate TS, an orange yellow precipitate is produced, to the second tube add mercuric potassium iodide TS, a yellow turbidity is produced. To the third test tube add silicotungstic acid TS, a greyish white turbidity is produced.3.Shake well 3 g of the powder with 5 ml of the concentrated ammonia TS and 50 ml of chloroform, stand over night, filter, evaporate the filtrate to dryness, dissolve the residue in 0.5 ml of chloroform as the reference drug solution. Prepare a solution of Radix Dipsaci reference drug in the same manner as the reference drug solution. Carry out the method fro thin l;ayer chromatography (Appendix Vl B), using silica gel G prepared with 2% sodium hydroxide solution as the coating substance and benzene-acetone-methanol (8:3:0.5) as the mobile phase. Apply separately to the plate 10 µl each of the two solutions. After developing and removal of the plate, spray with dilute potassium iodobismuthate TS and then 5% solution of sodium nitrite in 70% ethanol, stand for a moment, examine under daylight. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference drug solution.Extractives: Carry out the hot extraction method as described under the determination of water soluble extractives (Appendix X A). Not less than 45.0%.
Processing : Wash clean, soften thoroughly, cut into thin slices and dry.
Action : To replenish the liver and the kidney, to strengthen the tendons and bones, to heal bone fractures, and to arrest excessive uterine bleeding.
Indication : aching and weakness of the loins and knees; rheumatic arthralgia, abnormal uterine bleeding or excessive menstrual flow, uterine bleeding during pregnancy; traumatic injuries
Dosage : 9 to 15 g.
Storage : Preserve in a dry place, protected from moth.
Synonymns for Dipsacus japonicus
Patent Medicines and Medicines with Multiple Ingredients that include Dipsacus japonicus
Evidence or the Use of Dipsacus japonicus in the Treatment of Epilepesy
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
1st Five Results: pubmed search