Dipsacus asperoides

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Nomenclature

Other Names:

Historical Use of Dipsacus asperoides

Dipsacus asperoides in Traditional Chinese Medicine

Background

Chuanduan ´¨¶Ï Chuanduanrou ´¨¶ÏÈâ Chinese Name (pinyin): Xuduan

Chinese Name  :

Common Name  :Dipsacus Root

Specific Name  : Radix dipsaci

Scientific Name:
Collection  : The drug is collected in autumn, removed from root stock and rootlet, baked to half dry, piled up until green colour is developed inside and then baked to dryness.

Description  : Cylindrical, somewhat flattened, some slightly curved, 5 - 15 cm long, 0.5 - 2 cm in diameter. Externally greyish brown or yellowish brown with slightly twisted longitudinal wrinkles and furrows, showing transversal lenticels and sparse rootlet scars. Texture soft and hardened after long storage, easily broken, fracture uneven, bark dark green or brown, the outer part brown or pale brown, wood yellowish brown, vessels bundle arranged radially. Odour slightly aromatic, taste bitter, slightly sweet then astringent.

Identification  : 1.Transverse section: Cork consisting of several layers of cells. Cortex narrow. Groups of sieve tubes sparsely scattered in phloem. Cambium ring distinct or less distinct. Xylem ray broad, vessels dense near the cambium and lessened inward often singly scattered or 2 - 4 grouped. Pith small and mostly absent in small roots. Parenchymatous cells containing clusters of calcium oxalate.Powder: Yellowish brown, clusters of calcium oxalate fairly abundant, 15 - 50 µm in diameter, scattered through out or embedded in shrunken parenchymatous cells. Sometimes several clusters arranged in dense slat shape. The walls of fusiform parenchymatous cells slightly thickened with fine oblique crisscross striations. Bordered pits and reticulated vessels up to 72 (-90) µm in diameter. Cork cells pale brown, subrectangul;ar, subsquare polygonal or long polygonal in surface view with thin walls.2.To 5 g of the powder add 2 ml of ammonia TS, stir well then add 50 ml of chloroform. Heat under reflux for 1 hour and filter. Add 10 ml of hydrochloric acid solution (1Õ100) to the filtrate, shake well. Separate the acid solution, make alkaline with ammonia TS, add 10 ml ofchloroform and shake well. Separate the chloroform solution, add 5 ml of hydrochloric acid solution (1Õ100) and shake well. Transfer the acid solution into three test tubes respectively, to the first test tube add potassium iodobismuthate TS, an orange yellow precipitate is produced, to the second tube add mercuric potassium iodide TS, a yellow turbidity is produced. To the third test tube add silicotungstic acid TS, a greyish white turbidity is produced.3.Shake well 3 g of the powder with 5 ml of the concentrated ammonia TS and 50 ml of chloroform, stand over night, filter, evaporate the filtrate to dryness, dissolve the residue in 0.5 ml of chloroform as the reference drug solution. Prepare a solution of Radix Dipsaci reference drug in the same manner as the reference drug solution. Carry out the method fro thin l;ayer chromatography (Appendix Vl B), using silica gel G prepared with 2% sodium hydroxide solution as the coating substance and benzene-acetone-methanol (8:3:0.5) as the mobile phase. Apply separately to the plate 10 µl each of the two solutions. After developing and removal of the plate, spray with dilute potassium iodobismuthate TS and then 5% solution of sodium nitrite in 70% ethanol, stand for a moment, examine under daylight. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference drug solution.Extractives: Carry out the hot extraction method as described under the determination of water soluble extractives (Appendix X A). Not less than 45.0%.

Processing  : Wash clean, soften thoroughly, cut into thin slices and dry.

Action  : To replenish the liver and the kidney, to strengthen the tendons and bones, to heal bone fractures, and to arrest excessive uterine bleeding.

Indication  : aching and weakness of the loins and knees; rheumatic arthralgia, abnormal uterine bleeding or excessive menstrual flow, uterine bleeding during pregnancy; traumatic injuries

Precautions  :

Dosage  : 9 to 15 g.

Storage  : Preserve in a dry place, protected from moth.

Synonymns for Dipsacus asperoides

Patent Medicines and Medicines with Multiple Ingredients that include Dipsacus asperoides

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Dipsacus asperoides in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Jianbo He, Xiaojuan Li, Ziyi Wang, Samuel Bennett, Kai Chen, Zhifeng Xiao, Jiheng Zhan, Shudong Chen, Yu Hou, Junhao Chen, Shaofang Wang, Jiake Xu, Dingkun Lin
Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis.
Front Pharmacol: 2019, 10;1344
[PubMed:31824310] [WorldCat.org] [DOI] (P e)

Na-Rae Shin, A Yeong Lee, Gunhyuk Park, Je-Won Ko, Jong-Choon Kim, In-Sik Shin, Joong-Sun Kim
##Title##
Int J Mol Sci: 2019, 20(8);
[PubMed:30991656] [WorldCat.org] [DOI] (I e)

Li Sun, Zhengwei Yuan, Lingyan Jian, Qinghua Jiang, Siwen Zhang, Jichun Tan
The Modified Bushen Antai Recipe Upregulates Estrogen and Progesterone Receptors at the Maternal-Fetal Interface in Pregnant Rats with Mifepristone-Induced Pregnancy Loss.
Evid Based Complement Alternat Med: 2019, 2019;8312020
[PubMed:30792746] [WorldCat.org] [DOI] (P e)

Anhui Gong, Tao Zhou, Chenghong Xiao, Weike Jiang, Yongqiang Zhou, Jinqiang Zhang, Qing Liang, Changgui Yang, Wei Zheng, Chenggang Zhang
Association between dipsacus saponin VI level and diversity of endophytic fungi in roots of Dipsacus asperoides.
World J. Microbiol. Biotechnol.: 2019, 35(3);42
[PubMed:30778697] [WorldCat.org] [DOI] (I e)

Yong-Sheng Wei, Yuan Yue, Cong Yao, Xiao-Zhuo Wang, Xiang Liu, Xian-You Qu
[A developmental research on wild Dipsacus asper in Chongqing Wulong district].
Zhongguo Zhong Yao Za Zhi: 2018, 43(24);4837-4841
[PubMed:30717528] [WorldCat.org] [DOI] (P p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects