Daphne genkwa

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Nomenclature

Other Names:

Historical Use of Daphne genkwa

Daphne genkwa in Traditional Chinese Medicine

Background

Chenyuanhua ³Âܾ»¨ Cuyuanhua ´×ܾ»¨ Chinese Name (pinyin): Yuanhua

Chinese Name  :

Common Name  :Genkwa Flower

Specific Name  : Flos genkwa

Scientific Name:
Collection  : The drug is collected in spring before flowering, remove from foreign matter and dried.

Description  : Usually 3 - 7 flowers, subtended from 1 - 2 bracts, in cluster in shoots, mostly fallen off and a single flower remained, clavate, frequently curve, 1 - 1.7cm long about 1.5mm in diameter, parianth tube purplish or greyish green externally, densely pubescent, 4 lobe at the apex, lobes purplish or yellowish brown, texture soft, odour slight, taste slightly pungent.

Identification  : 1.In surface view: Pollen grains yellow, subpherical, 23 - 45µm in diameter, exine with distinct reticulate sculptures. Lower surface of parianth bearing non-glandular hairs, unicellular, usually curved, 88 - 780µm long, 15 - 23µm in diameter, walls relatively thick, slightly warty.2.Heat under reflux 1g of powder with 10ml of ethanol for 1 hour and filter. Add 1 drop of the filtrate to filter paper and then 1 drop of 1% ferric chloride solution, a dirty green colour is produced. To 1ml of the filtrate, add small quantity of magnesium powder and 1 drop of hydrochloric acid, warm on a water bath if necessary, a red color is produced.

Processing  : Eliminate foreign matter.Processed with vinegar: stir fry as described under the method for stir frying with vinegar (Appendix ll D) until vinegar is absorbed entirely using 30kg of vinegar per 100 of Flos Genkwa.

Action  : To cause drastic purgation and expel the retained water, and to kill parasites.

Indication  : anasarca, hydrothorax and ascites with dyspnea, constipation and oliguria external: scabies, tinea, frostbite

Precautions  : Contraindicated in pregnancy. Incompatible with Radix Glycyrrhizae.

Dosage  : 1.5 to 3 g. Flos Genkwa (processed with vinegar): To be ground into powder, 0.6 to 0.9 g, once daily.

Storage  : Preserve in a ventilated dry place, protected from mould and moth.

Synonymns for Daphne genkwa

Patent Medicines and Medicines with Multiple Ingredients that include Daphne genkwa

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Daphne genkwa in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Yann-Lii Leu, Tong-Hong Wang, Chih-Ching Wu, Kuo-Yen Huang, Yu-Wen Jiang, Yi-Chiung Hsu, Chi-Yuan Chen
Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation.
Molecules: 2020, 25(4);
[PubMed:32093124] [WorldCat.org] [DOI] (I e)

Jie Wang, Qing-Bo Liu, Zi-Lin Hou, Shao-Chun Shi, Hui Ren, Guo-Dong Yao, Bin Lin, Xiao-Xiao Huang, Shao-Jiang Song
Discovery of guaiane-type sesquiterpenoids from the roots of Daphne genkwa with neuroprotective effects.
Bioorg. Chem.: 2020, 95;103545
[PubMed:31927316] [WorldCat.org] [DOI] (I p)

Li-Fang Chou, Chi-Yuan Chen, Wan-Hua Yang, Chin-Chuan Chen, Junn-Liang Chang, Yann-Lii Leu, Miaw-Jene Liou, Tong-Hong Wang
Suppression of Hepatocellular Carcinoma Progression through FOXM1 and EMT Inhibition via Hydroxygenkwanin-Induced miR-320a Expression.
Biomolecules: 2019, 10(1);
[PubMed:31877715] [WorldCat.org] [DOI] (I e)

Hua-Ding Zhao, Yan Lu, Min Yan, Chin-Ho Chen, Susan L Morris-Natschke, Kuo-Hsiung Lee, Dao-Feng Chen
##Title##
J. Nat. Prod.: 2020, 83(1);134-141
[PubMed:31860304] [WorldCat.org] [DOI] (I p)

Ying-Ying Zhang, Xin-Yue Shang, Xue-Wen Hou, Ling-Zhi Li, Wei Wang, Toshihiko Hayashi, Yan Zhang, Guo-Dong Yao, Shao-Jiang Song
Yuanhuatine from Daphne genkwa selectively induces mitochondrial apoptosis in estrogen receptor α-positive breast cancer cells in vitro.
Planta Med.: 2019, 85(16);1275-1286
[PubMed:31627219] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects