Curculigo orchioides
Contents
Nomenclature
Other Names:
Historical Use of Curculigo orchioides
Curculigo orchioides in Traditional Chinese Medicine
Background
Chinese Name (pinyin): Xianmao
Chinese Name :
Common Name :Curculigo Rhizome
Specific Name : Rhizoma curculiginis
Scientific Name:
Collection : The drug is collected in autumn and winter, removed from root stock and fibrous root, washed clean and dried.
Description : Cylindrical, somewhat curved, 3 - 10 cm long, 4 - 8 mm in diameter. Externally blackish brown or brown, rugged with pitted fibrous root scars, showing longitudinal and transversal wrinkles. Texture hard and fragile, easily broken, fracture uneven, pale brown or brown and relatively darkened in colour near the center. Odour, slight, aromatic, taste bitterish and pungent.
Identification : 1.Transverse section: Cork consisting of 3 - 10 layers of cells. Cortex broad, occasionally showing root trace vascular bundles, some marginal cells containing prisms of calcium oxalate, endodermis distinct. Stele vascular bundles amphivasal or collateral, bundles scattered, mucilage cells numerous, scattered in parenchyma, subrounded, 60 - 200 µm in diameter containing raphides of calcium oxalate, 50 - 180µm long, Parenchymatous cells filled m with starch granules.2.Heat under reflux 2 g of the powder with 20 ml of ethanol on a water bath for 30 minutes and filter. Evaporate the filtrate to dryness, dissolve the residue in 1 ml of ethyl acetate, use the supernatant as the test solution. Dissolve curculigoside CRS ethyl acetate to produce a solution containing 0.1 mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G As the coating siubstance and ethyl acetate-methanol-formic acid (10:1:0.1) as the mobile phase. Apply separately to the plate 2 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and spray with a mixture of 2% solution of potassium ferrocyanide 2% solution of ferric chloride (1:1). The blue spot in the chromatogram obtained with the test solution corresponds in position and colour to the spot in the chromatogram obtained with the reference solution.Total ash: Not more than 10.0%
Processing : Eliminate foreign matter, wash clean, cut into sections and dry.
Action : To reinforce the kidney yang, to strenghten the tendons and bones, and to dispel cold-damp.
Indication : impotence; limpness of the limbs; arthritis of the lumbar and knee joints due to affection of cold-damp; watery diarrhea with aversion to cold
Precautions :
Dosage : 3 to 9 g.
Storage : Preserve in a dry place, proteted from mould and moth.
Synonymns for Curculigo orchioides
Patent Medicines and Medicines with Multiple Ingredients that include Curculigo orchioides
Pharmaceutical Information
Chemical Constituents
Evidence or the Use of Curculigo orchioides in the Treatment of Epilepesy
Basic Science
Animal Studies
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
Meta-Analysis
1st Five Results: pubmed search
Chenxia Lian, Wan Gong, Xuan Zhao, Peng Sun, Sijing Hu, Guifen Zhou, Qiaoyan Zhang, Luping Qin
Orcinol gentiobioside inhibits RANKL-induced osteoclastogenesis by promoting apoptosis and suppressing autophagy via the JNK1 signaling.
J Ethnopharmacol: 2024, 328;118060
[PubMed:38521429]
[WorldCat.org]
[DOI]
(I p)
Xia Liu, Mingchun Huang, Lijuan Wang, Jie Li, Weihui Wu, Qin Wang
Network pharmacology and experimental validation methods to reveal the active compounds and hub targets of Curculigo orchioides Gaertn in rheumatoid arthritis.
J Orthop Surg Res: 2023, 18(1);861
[PubMed:37957674]
[WorldCat.org]
[DOI]
(I e)
Fang Li, Hua Huang, Ping Zhao, Jie Jiang, Xufeng Ding, Donxgue Lu, Lijiang Ji
Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.
Int J Mol Med: 2023, 52(5);
[PubMed:37772380]
[WorldCat.org]
[DOI]
(I p)
Jun Gu Kim, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang
Molecular networking-assisted isolation of chlorophenolic glycosides from the rhizomes of Curculigo orchioides and their inhibitory effect on α-glucosidase.
Phytochemistry: 2023, 214;113820
[PubMed:37562563]
[WorldCat.org]
[DOI]
(I p)
Jing Wang, Junqiang Yang, Zonggui Tang, Yongbo Yu, Haiyun Chen, Qian Yu, Dawei Zhang, Chunyan Yan
Curculigo orchioides polysaccharide COP70-1 stimulates osteogenic differentiation of MC3T3-E1 cells by activating the BMP and Wnt signaling pathways.
Int J Biol Macromol: 2023, 248;125879
[PubMed:37473884]
[WorldCat.org]
[DOI]
(I p)
