Curculigo orchioides

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Nomenclature

Other Names:

Historical Use of Curculigo orchioides

Curculigo orchioides in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Xianmao

Chinese Name  :

Common Name  :Curculigo Rhizome

Specific Name  : Rhizoma curculiginis

Scientific Name:
Collection  : The drug is collected in autumn and winter, removed from root stock and fibrous root, washed clean and dried.

Description  : Cylindrical, somewhat curved, 3 - 10 cm long, 4 - 8 mm in diameter. Externally blackish brown or brown, rugged with pitted fibrous root scars, showing longitudinal and transversal wrinkles. Texture hard and fragile, easily broken, fracture uneven, pale brown or brown and relatively darkened in colour near the center. Odour, slight, aromatic, taste bitterish and pungent.

Identification  : 1.Transverse section: Cork consisting of 3 - 10 layers of cells. Cortex broad, occasionally showing root trace vascular bundles, some marginal cells containing prisms of calcium oxalate, endodermis distinct. Stele vascular bundles amphivasal or collateral, bundles scattered, mucilage cells numerous, scattered in parenchyma, subrounded, 60 - 200 µm in diameter containing raphides of calcium oxalate, 50 - 180µm long, Parenchymatous cells filled m with starch granules.2.Heat under reflux 2 g of the powder with 20 ml of ethanol on a water bath for 30 minutes and filter. Evaporate the filtrate to dryness, dissolve the residue in 1 ml of ethyl acetate, use the supernatant as the test solution. Dissolve curculigoside CRS ethyl acetate to produce a solution containing 0.1 mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G As the coating siubstance and ethyl acetate-methanol-formic acid (10:1:0.1) as the mobile phase. Apply separately to the plate 2 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and spray with a mixture of 2% solution of potassium ferrocyanide 2% solution of ferric chloride (1:1). The blue spot in the chromatogram obtained with the test solution corresponds in position and colour to the spot in the chromatogram obtained with the reference solution.Total ash: Not more than 10.0%

Processing  : Eliminate foreign matter, wash clean, cut into sections and dry.

Action  : To reinforce the kidney yang, to strenghten the tendons and bones, and to dispel cold-damp.

Indication  : impotence; limpness of the limbs; arthritis of the lumbar and knee joints due to affection of cold-damp; watery diarrhea with aversion to cold

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a dry place, proteted from mould and moth.

Synonymns for Curculigo orchioides

Patent Medicines and Medicines with Multiple Ingredients that include Curculigo orchioides

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Curculigo orchioides in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Xue-Li Deng, Rui-Rong Zheng, Zhu-Zhen Han, Li-Hua Gu, Zheng-Tao Wang
##Title##
J Asian Nat Prod Res: 2020;1-8
[PubMed:32131631] [WorldCat.org] [DOI] (I a)

Quanlong Zhang, Lu Zhao, Yi Shen, Yuqiong He, Gang Cheng, Ming Yin, Qiaoyan Zhang, Luping Qin
Curculigoside Protects against Excess-Iron-Induced Bone Loss by Attenuating Akt-FoxO1-Dependent Oxidative Damage to Mice and Osteoblastic MC3T3-E1 Cells.
Oxid Med Cell Longev: 2019, 2019;9281481
[PubMed:31949885] [WorldCat.org] [DOI] (I e)

Jianbo He, Xiaojuan Li, Ziyi Wang, Samuel Bennett, Kai Chen, Zhifeng Xiao, Jiheng Zhan, Shudong Chen, Yu Hou, Junhao Chen, Shaofang Wang, Jiake Xu, Dingkun Lin
Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis.
Front Pharmacol: 2019, 10;1344
[PubMed:31824310] [WorldCat.org] [DOI] (P e)

Shirui Tan, Jian Xu, Aiyun Lai, Ruomei Cui, Ru Bai, Shu Li, Wei Liang, Guofang Zhang, Shaoquan Jiang, Shuang Liu, Mai Zheng, Wei Wang
Curculigoside exerts significant anti‑arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF‑κB signaling pathway.
Mol Med Rep: 2019, 19(3);2057-2064
[PubMed:30664158] [WorldCat.org] [DOI] (I p)

Xueqian Wang, Mengliu Zhang, Dawei Zhang, Xinluan Wang, Huijuan Cao, Qian Zhang, Chunyan Yan
Structural elucidation and anti-osteoporosis activities of polysaccharides obtained from Curculigo orchioides.
Carbohydr Polym: 2019, 203;292-301
[PubMed:30318216] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects