Crocus sativus

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P162 2.jpg
P162 1.jpg
Tcm316.jpg

Nomenclature

Other Names:

Historical Use of Crocus sativus

Crocus sativus in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Xihonghua

Chinese Name  :

Common Name  :Saffron

Specific Name  : Stigma croci

Scientific Name:
Collection  :

Description  : Linear, 3 branched about 3 cm long, dark red, the upper part broader and slightly flattened, the margin of apex irregularly dented with a short slit at the inner side, sometimes a small piece of yellow style remained at the lower end. Texture light, lax and soft without oily lustre, brittle and short after drying. Odor characteristic slightly irritant and taste slightly bitter.

Identification  : 1.Powder: Orange red. Epidermal cells long stripe shape in surface view, thin walled, slightly sinouos, sometimes the outer walls protruding and showing papillae with indistinct fine striations. Terminal epidermal cells of stigma papillated. 26 - 56 µm in diameter with sparse striations on surface. Parenchymatous cells crowded with crystals of calcium oxalate, granular, round fascicled fusiform or sub-square, 2 - 14µm in diameter.2.Macerate a small quantity of the drug in water, the orange yellow color descends vertically and diffuses slowly while the solution is yellow without precipitation. Stigma looks like a loudspeaker with short chink which is not broken in a short time when picked with a needle.3.Place a small quantity of the drug on a white porcelain plate, add 1 drop of sulfuric acid, a blue to purple color is produced which turns to reddish brown or brown gradually.4.Measure the absorbance of the solution obtained under the test for absorbance at 458 nm (Appendix V B), The ratio of the absorbance at 458 nm to that at 432 nm in 0.85 - 0.90.Loss on drying: After drying 2 g at 105ºC for 6 hours, loses not more than 12.0% of its weight (Appendix 1X G).Total ash: Not more than 7.5% (Appendix 1X K)Absorbance: Dry the drug in vacuum desiccator over silica gel for 24 hours and grind into fine powder. Weigh accurately 30 mg into a Soxhlet's extractor. Extract with 70 ml of ethanol under reflux and cool. Transfer the extract to a 100 ml volumetric flask, filter if necessary. Wash the extractor with methanol, transfer the washings into the volumetric flask, dilute with methanol; to volume and mix well. Measure accurately 5 ml to a 50ml volumetric flask, dilute with methanol to volume and mix well. Measure the absorbance at 432 nm (Appendix V B) not less than 0.5.

Processing  :

Action  : To activate blood circulation and eliminate blood stasis fter childbirth; eruptions in infectious diseases; emotional dejection, mani.

Indication  :

Precautions  : Used with caution in pregnancy.

Dosage  : 3 to 9 g.

Storage  : Preserve in tightly closed containers, stored in a cool and dry place, protected from light.

P162 2.jpg
P162 1.jpg
Tcm316.jpg

Nomenclature

Other Names:

Historical Use of Crocus sativus

Crocus sativus in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Xihonghua

Chinese Name  :

Common Name  :Saffron

Specific Name  : Stigma croci

Scientific Name:
Collection  :

Description  : Linear, 3 branched about 3 cm long, dark red, the upper part broader and slightly flattened, the margin of apex irregularly dented with a short slit at the inner side, sometimes a small piece of yellow style remained at the lower end. Texture light, lax and soft without oily lustre, brittle and short after drying. Odor characteristic slightly irritant and taste slightly bitter.

Identification  : 1.Powder: Orange red. Epidermal cells long stripe shape in surface view, thin walled, slightly sinouos, sometimes the outer walls protruding and showing papillae with indistinct fine striations. Terminal epidermal cells of stigma papillated. 26 - 56 µm in diameter with sparse striations on surface. Parenchymatous cells crowded with crystals of calcium oxalate, granular, round fascicled fusiform or sub-square, 2 - 14µm in diameter.2.Macerate a small quantity of the drug in water, the orange yellow color descends vertically and diffuses slowly while the solution is yellow without precipitation. Stigma looks like a loudspeaker with short chink which is not broken in a short time when picked with a needle.3.Place a small quantity of the drug on a white porcelain plate, add 1 drop of sulfuric acid, a blue to purple color is produced which turns to reddish brown or brown gradually.4.Measure the absorbance of the solution obtained under the test for absorbance at 458 nm (Appendix V B), The ratio of the absorbance at 458 nm to that at 432 nm in 0.85 - 0.90.Loss on drying: After drying 2 g at 105ºC for 6 hours, loses not more than 12.0% of its weight (Appendix 1X G).Total ash: Not more than 7.5% (Appendix 1X K)Absorbance: Dry the drug in vacuum desiccator over silica gel for 24 hours and grind into fine powder. Weigh accurately 30 mg into a Soxhlet's extractor. Extract with 70 ml of ethanol under reflux and cool. Transfer the extract to a 100 ml volumetric flask, filter if necessary. Wash the extractor with methanol, transfer the washings into the volumetric flask, dilute with methanol; to volume and mix well. Measure accurately 5 ml to a 50ml volumetric flask, dilute with methanol to volume and mix well. Measure the absorbance at 432 nm (Appendix V B) not less than 0.5.

Processing  :

Action  : To activate blood circulation and eliminate blood stasis fter childbirth; eruptions in infectious diseases; emotional dejection, mani.

Indication  :

Precautions  : Used with caution in pregnancy.

Dosage  : 3 to 9 g.

Storage  : Preserve in tightly closed containers, stored in a cool and dry place, protected from light.

P162 2.jpg
P162 1.jpg
Tcm316.jpg

Nomenclature

Other Names:

Historical Use of Crocus sativus

Crocus sativus in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Xihonghua

Chinese Name  :

Common Name  :Saffron

Specific Name  : Stigma croci

Scientific Name:
Collection  :

Description  : Linear, 3 branched about 3 cm long, dark red, the upper part broader and slightly flattened, the margin of apex irregularly dented with a short slit at the inner side, sometimes a small piece of yellow style remained at the lower end. Texture light, lax and soft without oily lustre, brittle and short after drying. Odor characteristic slightly irritant and taste slightly bitter.

Identification  : 1.Powder: Orange red. Epidermal cells long stripe shape in surface view, thin walled, slightly sinouos, sometimes the outer walls protruding and showing papillae with indistinct fine striations. Terminal epidermal cells of stigma papillated. 26 - 56 µm in diameter with sparse striations on surface. Parenchymatous cells crowded with crystals of calcium oxalate, granular, round fascicled fusiform or sub-square, 2 - 14µm in diameter.2.Macerate a small quantity of the drug in water, the orange yellow color descends vertically and diffuses slowly while the solution is yellow without precipitation. Stigma looks like a loudspeaker with short chink which is not broken in a short time when picked with a needle.3.Place a small quantity of the drug on a white porcelain plate, add 1 drop of sulfuric acid, a blue to purple color is produced which turns to reddish brown or brown gradually.4.Measure the absorbance of the solution obtained under the test for absorbance at 458 nm (Appendix V B), The ratio of the absorbance at 458 nm to that at 432 nm in 0.85 - 0.90.Loss on drying: After drying 2 g at 105ºC for 6 hours, loses not more than 12.0% of its weight (Appendix 1X G).Total ash: Not more than 7.5% (Appendix 1X K)Absorbance: Dry the drug in vacuum desiccator over silica gel for 24 hours and grind into fine powder. Weigh accurately 30 mg into a Soxhlet's extractor. Extract with 70 ml of ethanol under reflux and cool. Transfer the extract to a 100 ml volumetric flask, filter if necessary. Wash the extractor with methanol, transfer the washings into the volumetric flask, dilute with methanol; to volume and mix well. Measure accurately 5 ml to a 50ml volumetric flask, dilute with methanol to volume and mix well. Measure the absorbance at 432 nm (Appendix V B) not less than 0.5.

Processing  :

Action  : To activate blood circulation and eliminate blood stasis fter childbirth; eruptions in infectious diseases; emotional dejection, mani.

Indication  :

Precautions  : Used with caution in pregnancy.

Dosage  : 3 to 9 g.

Storage  : Preserve in tightly closed containers, stored in a cool and dry place, protected from light.

P162 2.jpg
P162 1.jpg
Tcm316.jpg

Nomenclature

Other Names:

Historical Use of Crocus sativus

Crocus sativus in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Xihonghua

Chinese Name  :

Common Name  :Saffron

Specific Name  : Stigma croci

Scientific Name:
Collection  :

Description  : Linear, 3 branched about 3 cm long, dark red, the upper part broader and slightly flattened, the margin of apex irregularly dented with a short slit at the inner side, sometimes a small piece of yellow style remained at the lower end. Texture light, lax and soft without oily lustre, brittle and short after drying. Odor characteristic slightly irritant and taste slightly bitter.

Identification  : 1.Powder: Orange red. Epidermal cells long stripe shape in surface view, thin walled, slightly sinouos, sometimes the outer walls protruding and showing papillae with indistinct fine striations. Terminal epidermal cells of stigma papillated. 26 - 56 µm in diameter with sparse striations on surface. Parenchymatous cells crowded with crystals of calcium oxalate, granular, round fascicled fusiform or sub-square, 2 - 14µm in diameter.2.Macerate a small quantity of the drug in water, the orange yellow color descends vertically and diffuses slowly while the solution is yellow without precipitation. Stigma looks like a loudspeaker with short chink which is not broken in a short time when picked with a needle.3.Place a small quantity of the drug on a white porcelain plate, add 1 drop of sulfuric acid, a blue to purple color is produced which turns to reddish brown or brown gradually.4.Measure the absorbance of the solution obtained under the test for absorbance at 458 nm (Appendix V B), The ratio of the absorbance at 458 nm to that at 432 nm in 0.85 - 0.90.Loss on drying: After drying 2 g at 105ºC for 6 hours, loses not more than 12.0% of its weight (Appendix 1X G).Total ash: Not more than 7.5% (Appendix 1X K)Absorbance: Dry the drug in vacuum desiccator over silica gel for 24 hours and grind into fine powder. Weigh accurately 30 mg into a Soxhlet's extractor. Extract with 70 ml of ethanol under reflux and cool. Transfer the extract to a 100 ml volumetric flask, filter if necessary. Wash the extractor with methanol, transfer the washings into the volumetric flask, dilute with methanol; to volume and mix well. Measure accurately 5 ml to a 50ml volumetric flask, dilute with methanol to volume and mix well. Measure the absorbance at 432 nm (Appendix V B) not less than 0.5.

Processing  :

Action  : To activate blood circulation and eliminate blood stasis fter childbirth; eruptions in infectious diseases; emotional dejection, mani.

Indication  :

Precautions  : Used with caution in pregnancy.

Dosage  : 3 to 9 g.

Storage  : Preserve in tightly closed containers, stored in a cool and dry place, protected from light.

Synonymns for Crocus sativus

Patent Medicines and Medicines with Multiple Ingredients that include Crocus sativus

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Crocus sativus in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Roya Haghighi, Badraldin Ebrahim Sayed Tabatabaei, Sayed Ali Mohammad Mirmohammadi Maibody, Majid Talebi, R V Molina, Sergio G Nebauer, Begoña Renau-Morata
A flowering inhibitor of the temperature-dependent pathway in Crocus sativus L.
Mol. Biol. Rep.: 2020;
[PubMed:32065325] [WorldCat.org] [DOI] (I a)

Shokofeh Rahmani, Jamileh Saberzadeh, Mohammad Ali Takhshid
##Title##
Iran J Med Sci: 2020, 45(1);59-66
[PubMed:32038060] [WorldCat.org] [DOI] (P p)

Monica Bononi, Fernando Tateo, Barbara Scaglia, Giancarlo Quaglia
##Title##
Food Chem: 2020, 315;126292
[PubMed:32035314] [WorldCat.org] [DOI] (I p)

Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Yusra Al Dhaheri, Muneeb U Rehman, Ambreen Shoaib, Omar Sarheed, Salma Jabnoun, Maryam Razmpoor, Saiema Rasool, Bilal Ahmad Paray, Parvaiz Ahmad
##Title##
Plants (Basel): 2020, 9(2);
[PubMed:32019201] [WorldCat.org] [DOI] (P e)

Milad Iranshahy, Behjat Javadi
Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.
Iran J Basic Med Sci: 2019, 22(10);1102-1117
[PubMed:31998450] [WorldCat.org] [DOI] (P p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects