Cornus officinalis

Background

Shanyurou ɽÝÇÈâ Chinese Name (pinyin): Shanzhuyu

Chinese Name  :

Common Name  :Dogwood Fruit

Specific Name  : Fructus corni

Scientific Name:
Collection  : The fruit is collected in later autumn and early winter when the pericarp turns red, baked over a soft fir oe treated with boiling water for moment, removed from kern in time and dried.

Description  : Irregularly flaky or bladdery, 1 - 5cm long and 0.5 - 1cm wide. Externally purplish red to purplish black, shrunken, lustrous. Sometimes with a rounded scar or persistent calyx at the apex and scar of fruit stalk at the base. Texture soft, odor slight, taste sour astringent and slightly bitter.

Identification  : Powder: reddish brown. Epidermal cells of cells pericarp polygonal or subrectangular in surface view. 16 - 30µm in diameter, anitclinal walls beaded, outer periclinal walls granularly cutinized and thickened, lumen containing pale orange yellow contents. Cells of emsocarp, orange brown mostly shrunken. Clusters of calcium oxalate rare 12 - 32µm in diameter. Stone cells subsquare, ovoid or rectangular, pits obvious and with a large lumen.Foreign matter: (kerns and fruit stalks) not more than 3% (Appendix lX A).Assay: Place about 1g of the coarser powder, accurately weighed in a Soxhlet's extractor, heat under reflux with a quantity of ether for 4 hours. Recover ether from the extract and evaporate to dryness. Macerate the residue with two quantities, each of 15ml of petroleum ether (30 - 60ºC) for about 2 minutes each time, discard the petroleum ether solution. Dissolve the residue in a solution of dehydrated ethanol-chloroform (3:2) by gentle heat. Transfer the solution to a 5ml volumetric flask, dilute to volume, shake well, use as the test solution. Dissolve ursolic acid CRS, weighed accurately in dehydrated ethanol to produce a solution conataining 0.5mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B) using silica gel G as the coating substance and cyclohexane-chloroform-ethyl acetate (20:5:8) as the mobile phase. Apply separately 5µl and 10µl of the test solution and 4µl and 8µl of the reference solution to the plate. After develoipingg and removal of the plate, dry it in the air, spray with a 10% solution of sulfuric acid in ethanol, heat at 110ºC for 5 - 7 minutes until purplish red spots appear. Cover the plate with a piece of glass of the same size and fix with a tape. Carry out the method for thin layer chromatogaphy (thin layer chromatographic scanning mtahod) (Appendix Vl B), scan at the wave lengths of ?s 520nm and ?R 700 nm. Determine the integral absorbance value of the test solution and reference solution respectively and calculate the content of ursolic acid. It contains not less than 0.2% of ursolic acid (C30H48 O3).

Processing  : ulp of Fructus corni, eliminate foreign matter and remained kerns.Processed with wine: stew or steam the pulp as describe uunder the method for stewing with wine or steaming with wine (Appendix ll D) until the wine is absorbed entirely.

Action  : To replenish the liver and kidney, restrain seminal discharge and relieve collapse.

Indication  : dizziness, tinnitus, soreness in the loins and knees, impotence, seminal emission, enuresis, increased frequency of urination, excessive uterine bleeding and leukorrhea, collapse with profuse sweating diabetes

Precautions  :

Dosage  : 6 to 12 g.

Storage  : Preserve in a dry place, protected from moth.

Evidence or the Use of Cornus officinalis in the Treatment of Epilepesy

1st Five Results: pubmed search

Jinyi Zhang, Po Niu, Mingjie Li, Yuan Wang, Yao Ma, Pan Wang
##Title##
Molecules: 2024, 29(7);
[PubMed:38611753] [WorldCat.org] [DOI] (I e)

Hyun Hwangbo, Cheol Park, EunJin Bang, Hyuk Soon Kim, Sung-Jin Bae, Eunjeong Kim, Youngmi Jung, Sun-Hee Leem, Young Rok Seo, Su Hyun Hong, Gi-Young Kim, Jin Won Hyun, Yung Hyun Choi
Morroniside Protects C2C12 Myoblasts from Oxidative Damage Caused by ROS-Mediated Mitochondrial Damage and Induction of Endoplasmic Reticulum Stress.
Biomol Ther (Seoul): 2024;
[PubMed:38602043] [WorldCat.org] [DOI] (P a)

Jie Wang, Aoying Zhang, Yulong Hu, Xin Yuan, Yuanhao Qiu, Chunhong Dong
Polysaccharides from fructus corni: Extraction, purification, structural features, and biological activities.
Carbohydr Res: 2024, 538;109072
[PubMed:38484601] [WorldCat.org] [DOI] (I p)

Haotian Zheng, Linxin Yang, Huashang Huang, Yazhou Lin, Lin Chen
Morroniside improves AngII-induced cardiac fibroblast proliferation, migration, and extracellular matrix deposition by blocking p38/JNK signaling pathway through the downregulation of KLF5.
Naunyn Schmiedebergs Arch Pharmacol: 2024;
[PubMed:38472369] [WorldCat.org] [DOI] (I a)

Md Shimul Bhuia, Raihan Chowdhury, Iffat Ara, Md Mamun, Razina Rouf, Muahmmad Ali Khan, Shaikh Jamal Uddin, Md Abdul Kader Shakil, Solomon Habtemariam, Jannatul Ferdous, Daniela Calina, Javad Sharifi-Rad, Muhammad Torequl Islam
Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms.
Fitoterapia: 2024, 175;105896
[PubMed:38471574] [WorldCat.org] [DOI] (I a)