Clinopodium chinense

Background

Chinese Name (pinyin): Duanxueliu

Chinese Name  :

Common Name  :Clinopodium herb

Specific Name  : Herba clinopodii

Scientific Name:
Collection  : The drug is collected before flowering in summer, removed from soil and dried in the sun.

Description  : Stem square, furrowed on four sides, branches opposite, 30 - 90cm long, 1.5 - 4mm in diameter, the upper part densely covered with greyish white hairs, the lower part sparsely pubescent or nearly glabrous, interenodes 2 - 8cm long, externally greyish green or greenish brown, texture fragile, easily broken,fracturre uneven, medullated or hollowed in the center. Leaves opposite petioled, mostly crumpled and broken when whole, ovate, 2 - 5cm long, 1.5 - 3.2cm wide, margin sparsely serrate, the upper surface greenish brown, the lower surface greyish green, both surfaces densely covered with white hairs. Odour slightly aromatic, taste astringent and slightly bitter.

Identification  : 1.Surface view of leaf: Anticlinal walls of epidermal cells sinuous, stomata diacytic, non-glandular hairs slender, numerous, consisting of 1 - 9 cells up to 14440µm long, some basal cells expanded up to 102µm in diameter, cells of the middle part 10 - 55µm in diameter, some cells constricted with warty prominences on the surface, glandular scales with 7 - 11 celled head up to 60 µm in diameter and unicellular, very short stalk, small glandular hairs with a unicellular head, about 20µm in diameter and a unicellular stalk.2.To 1g of the powder, add 10ml of methanol, heat under reflux on a water bath for 30 minutes, filter. Carry out the method for column chromatography (Appendix Vl C), apply the filtrate to a pretreated neutral aluminum oxide column (10 - 15mm in internal diameter packed with 10g, 100 - 120 mesh) ellute with 40ml of 40% methanol. Collect the eluate. Evaporate the eluate to dryness on a water bath, dissolve the residue in 30ml of water, extract with two quantities of 20ml each of h-butanol saturated with water. Combine the h-butanol extracts, wash with two quantities of 20ml each of water. Discard the washings, evaporate the h-butanol extracts to dryness on a water bath, dissolve the residue in 1ml of methanol as the test solution. To clinopodium saponin CRS, add ethanol to produce a solution containing 2mg per ml as the reference solution. Carry out the method for thin layer chromatogram (Appendix Vl B) using silca gel G containing 1% sodium hydroxide solution as the coating substance and the lower layer of the mixture of chloroform ethyl acetate-water (15:40:22:10), after standing under 10ºC as the mobile phase. Apply separately to the plate 2µl of each of the two solutions. After developing and removal of the plate, dry it in the air, spray with 10% solution of sulfuric acid ethanol, heat at 110ºC for several minutes, a purplish blue spot in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference solution. Examine under ultra violet light (365nm), the spots show the same brownish red fluorescence.

Processing  : Eliminate foreign matter, soften briefly with water, cut into sections and dry in the sun.

Action  : To arrest bleeding.

Indication  : excessive menstrual discharge, hemorrhage from hysteromyoma, hematuria, epistaxis, gingival bleeding, traumatic bleeding

Precautions  :

Dosage  : 9 to 15 g; for external use, appropriate quantity to be ground into powder or the fresh herb to be pounded into topical application.

Storage  : Preserve in a dry place, protected from moisture.

Evidence or the Use of Clinopodium chinense in the Treatment of Epilepesy

1st Five Results: pubmed search

Zhang Hai-Jing, Chen Rong-Chang, Sun Gui-Bo, Yang Long-Po, Zhu Yin-di, Xu Xu-Dong, Sun Xiao-Bo
Corrigendum to "Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway" [Phytomedicine 40 (2018) 88-97].
Phytomedicine: 2024;155514
[PubMed:38490893] [WorldCat.org] [DOI] (I a)

Yumeng Wang, Kaicheng Du, Quanyou Wang, Xinyong Yang, Dali Meng
A multidimensional strategy for characterization, distinction, and quality control of two Clinopodium medicinal plants.
J Ethnopharmacol: 2024, 327;118019
[PubMed:38467319] [WorldCat.org] [DOI] (I p)

Mingyi Shen, Changwei Zheng, Zhijin Hao, Huijie Song, Yumeng Wang, Dali Meng
Undescribed compounds from Clinopodium chinense (Benth.) O. Kuntze and their coagulation activity studies.
Fitoterapia: 2024, 172;105736
[PubMed:37939735] [WorldCat.org] [DOI] (I p)

Zhonghao Sun, Zhaocui Sun, Daoshun Wu, Fan Yi, Haifeng Wu, Guoxu Ma, Xudong Xu
Gram-Scale Total Synthesis of TAB with Cardioprotective Activity and the Structure-Activity Relationship of Its Analogs.
Molecules: 2023, 28(13);
[PubMed:37446862] [WorldCat.org] [DOI] (I e)

Lili Li, Jiajia Qi, Hong Tao, Lele Wang, Lu Wang, Ning Wang, Qi Huang
Protective effect of the total flavonoids from Clinopodium chinense against LPS-induced mice endometritis by inhibiting NLRP3 inflammasome-mediated pyroptosis.
J Ethnopharmacol: 2023, 312;116489
[PubMed:37054825] [WorldCat.org] [DOI] (I p)