Brucea javanica
Contents
Nomenclature
Other Names:
Historical Use of Brucea javanica
Brucea javanica in Traditional Chinese Medicine
Background
Yadanyou Ñ»µ¨ÓÍ
Chinese Name (pinyin): Yadanzi
Chinese Name :
Common Name :Brucea Fruit
Specific Name : Fructus bruceae
Scientific Name:
Collection : The drug is collected in autumn when ripe, removed from foreign matter and dried in the sun.
Description : Ovoid, 6 - 10mm long, 4 - 7mm in diameter. Externally black or brown with raised reticulate wrinkles, lumina irregularly polygonal, obviously ribbed at both sides. Apex acuminate, base having a dented fruit stalk scar, shell hard and brittle. Seeds ovoid, 5 - 6mm long, 3 - 5mm in diameter, externally whitish or yellowish white with reticulate, testa thin, cotyledons milky white oily. Odorless, taste extremely bitter.
Identification : Powder opf pericarp: Epidermal cells polygonal, containing brown contents, parenchymatous cells polygonal, containing clusters of calcium oxalate up to 30µm in diameter and prisms. Stone cells subrounded or polygonal, 14 - 38µm in diameter.Powder of seed: yellowish white. The cells of testa polygonal, slightly elongated. The cells of endosperm and cotyledon containing aleurone grains.
Processing : Eliminate shells and foreign matter.
Action : To remove toxic heat, to stop malarial attacks, to relieve dysentery, and to cauterize vegetations.
Indication : dysentery, malaria
external: vegetation, corn
Precautions :
Dosage : 0.5 to 2 g to be taken after wrapped in Arillus Longan or in capsules; appropraite quantity for external use.
Storage : Preserve in a dry place.
Synonymns for Brucea javanica
Patent Medicines and Medicines with Multiple Ingredients that include Brucea javanica
Pharmaceutical Information
Chemical Constituents
Evidence or the Use of Brucea javanica in the Treatment of Epilepesy
Basic Science
Animal Studies
Cohort, Case-Control and Non-Randomized Trials
Randomized Controlled Trials
Meta-Analysis
1st Five Results: pubmed search
Li Sun, Yumeng Wang, Jia Li, Shiqing Xu, Shuang Xu, Jun Li
Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells.
Chem Biol Interact: 2024;110999
[PubMed:38608999]
[WorldCat.org]
[DOI]
(I a)
Nor Syaidatul Akmal Mohd Yousof, Adlin Afzan, Murizal Zainol, Syahrul Imran Abu Bakar, Mohd Ridzuan Mohd Abd Razak, Nur Hana Md Jelas, Nor Nadirah Abdullah, Geoffrey A Cordell, Nor Hadiani Ismail
Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes.
Fitoterapia: 2024, 175;105955
[PubMed:38604259]
[WorldCat.org]
[DOI]
(I a)
Xiaodong Li, Yuankuan Jiang, Ying Wang, Na Li, Shumeng Zhang, Kejia Lv, Renchuan Jia, Tianfu Wei, Xiaojie Li, Chuanchun Han, Jingrong Lin
KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma.
Biochem Pharmacol: 2024, 223;116197
[PubMed:38583810]
[WorldCat.org]
[DOI]
(I a)
BioMed Research International
Retracted: Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy.
Biomed Res Int: 2024, 2024;9826927
[PubMed:38550010]
[WorldCat.org]
[DOI]
(I e)
Pandu Ishaq Nandana, Haerani Rasyid, Prihantono Prihantono, Ika Yustisia, Lukman Hakim, Agussalim Bukhari, Eka Sunarwidhi Prasedya
Cytotoxicity and Apoptosis Studies of Brucein D against T24 Bladder Cancer Cells.
Asian Pac J Cancer Prev: 2024, 25(3);921-930
[PubMed:38546074]
[WorldCat.org]
[DOI]
(I e)
