Brucea javanica

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Other Names:

Historical Use of Brucea javanica

Brucea javanica in Traditional Chinese Medicine


Yadanyou Ñ»µ¨ÓÍ Chinese Name (pinyin): Yadanzi

Chinese Name  :

Common Name  :Brucea Fruit

Specific Name  : Fructus bruceae

Scientific Name:
Collection  : The drug is collected in autumn when ripe, removed from foreign matter and dried in the sun.

Description  : Ovoid, 6 - 10mm long, 4 - 7mm in diameter. Externally black or brown with raised reticulate wrinkles, lumina irregularly polygonal, obviously ribbed at both sides. Apex acuminate, base having a dented fruit stalk scar, shell hard and brittle. Seeds ovoid, 5 - 6mm long, 3 - 5mm in diameter, externally whitish or yellowish white with reticulate, testa thin, cotyledons milky white oily. Odorless, taste extremely bitter.

Identification  : Powder opf pericarp: Epidermal cells polygonal, containing brown contents, parenchymatous cells polygonal, containing clusters of calcium oxalate up to 30µm in diameter and prisms. Stone cells subrounded or polygonal, 14 - 38µm in diameter.Powder of seed: yellowish white. The cells of testa polygonal, slightly elongated. The cells of endosperm and cotyledon containing aleurone grains.

Processing  : Eliminate shells and foreign matter.

Action  : To remove toxic heat, to stop malarial attacks, to relieve dysentery, and to cauterize vegetations.

Indication  : dysentery, malaria external: vegetation, corn

Precautions  :

Dosage  : 0.5 to 2 g to be taken after wrapped in Arillus Longan or in capsules; appropraite quantity for external use.

Storage  : Preserve in a dry place.

Synonymns for Brucea javanica

Patent Medicines and Medicines with Multiple Ingredients that include Brucea javanica

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Brucea javanica in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials


1st Five Results: pubmed search

Can Luo, Yu Wang, Cheng Wei, Yuxin Chen, Zhaoning Ji
The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
Exp Ther Med: 2020, 19(1);273-279
[PubMed:31853299] [] [DOI] (P p)

Jian-Hui Xie, Zheng-Quan Lai, Xing-Han Zheng, Yan-Fang Xian, Qian Li, Siu-Po Ip, You-Liang Xie, Jian-Nan Chen, Zi-Ren Su, Zhi-Xiu Lin, Xiao-Bo Yang
Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling.
Int. J. Mol. Med.: 2019, 44(6);2015-2026
[PubMed:31638181] [] [DOI] (I p)

Yawen Li, Angelina Angelova, Fangzhou Hu, Vasil M Garamus, Changjun Peng, Na Li, Jianwen Liu, Dan Liu, Aihua Zou
Langmuir: 2019, 35(45);14532-14542
[PubMed:31635451] [] [DOI] (I p)

Shangyu Wang, Hongzhi Hu, Binlong Zhong, Deyao Shi, Xiangcheng Qing, Cheng Cheng, Xiangyu Deng, Zhicai Zhang, Zengwu Shao
Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway.
Cancer Med: 2019, 8(17);7345-7358
[PubMed:31631559] [] [DOI] (I p)

Jiyeon Baek, Hyejeong Jeong, Youngwook Ham, Yang Hee Jo, Miri Choi, Mingu Kang, Bora Son, Sangho Choi, Hyung Won Ryu, Janghwan Kim, Haihong Shen, Kongmany Sydara, Sang Woo Lee, Soo-Yong Kim, Sang-Bae Han, Sei-Ryang Oh, Sungchan Cho
Improvement of spinal muscular atrophy via correction of the SMN2 splicing defect by Brucea javanica (L.) Merr. extract and Bruceine D.
Phytomedicine: 2019, 65;153089
[PubMed:31563042] [] [DOI] (I p)



Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects