Baphicacanthus cusia

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Nomenclature

Other Names:

Historical Use of Baphicacanthus cusia

Baphicacanthus cusia in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Qingdai

Chinese Name  :

Common Name  :Natural Indigo

Specific Name  : Indigo naturalis

Scientific Name:
Collection  :

Description  : Description: a deep blue powder, light and pufffy or irregular and porous masses, finely powdered on twisting, odour slightly grassy and taste weak.

Identification  : 1.Burn gently small quantity of powder, a purplish red smoke is produced.2.To a small quantity of the powder, add nitric acid dropwise, a brownish red or yellowish brown colour s produced with effervescence.3.To 50mg of the drug add 5ml of chloroform, stir well and filter, the filtrate used as the test solution. Dissolve indigo CRS and indirubin CRS in chloroform to prepare a solution containing 1mg of each per ml. Use as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and benzene-chloroform-acetone (5:4:1) as the mobile phase. Apply separately to the plate 5 - 10µl of each of the two solutions. After developing and removal of the plate, dry it in the air. The blue spot and pale purplish red spot in the chromatogram obtained with the test solution correspond in position and colour to the spots in the chromatogram obtained with the reference solution.Water soluble pigment: Shake 0.5g of the powder with 10 ml of water and allow to stand for a moment, the water layer shows no deep blue colour.Assay: Reference preparation: Sulfonate 20mg of indigo CRS accurately weighed in a flask by adding 15ml of sulfuric acid slowly and with a constant stiring gently on a water bath at 80ºC for 1 hour. Allow to cool, transfer the solution slowly to a 200ml volumetric flask containing a quality of water. Wash the flask and the residue with water. Combine the washing to a volumetric flask, add water to volume and mix well. Filter and discard the initial filtrate. Measure accurately 5ml of the successive filtrate to a 50ml volumetric flask, add water and mix well (containing 10µg of indigo per ml.Preparation of standard curve: Measure accurately 1.0, 2.0, 3.0, 4.0, and 5.0ml of the reference solution respectively into a 10ml volumetric flask, add water to volume and mix well. Carry out the method for spectrophotometry (Appendix V B). Measure the absorbance at 610nm and plot the standard curve using the absorbance as ordinate and concentration abscissa.Procedure: Weigh accurately 0.4g of the fine powder, carry out the procedure as described under reference preparation, beginning at the words "in a flask Media wiki admin 19:21, 27 November 2012 (EST)" to" discard the initial filtrate, measure accurately 5ml of the successive filtrate". Transfer the filtrate to a 50ml or 100ml volumetric flask (adjust the absorbance to be within 0.20 - 0.45), add water to volume and mix well. Measure the absorbance at 610nm and read out the weight of indigo (µg) in the test solution from the standard curve and calculate the percentage content of C16H10N2O2. It contains not less than 2.0% of Indigo.

Processing  :

Action  : To remove toxic heat, to reduce heat in blood, and to relieve convulsions.

Indication  : eruptive epidemic diseases; spitting of blood and epistaxis due to heat in the blood, chest pain and hemoptysis; ulcers in the mouth; mumps; pharyngitis, laryngitis; infantile convulsions

Precautions  :

Dosage  : 1.5 to 3 g, used for making pills or powder, appropriate quantity for exteranl use.

Storage  : Preserve in a dry place.

P256 2.jpg
Tcm308.jpg
P254 2.jpg

Nomenclature

Other Names:

Historical Use of Baphicacanthus cusia

Baphicacanthus cusia in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Nanbanlangen

Chinese Name  :

Common Name  :Baphicacanthus Root

Specific Name  : Rhizoma et radix baphicacanthis cusae

Scientific Name:
Collection  : The drug is collected in summer and autumn, deprive from the aerial part, wash clean and dried in the sun.

Description  : Description: Rhizome subrounded, mostly tortous, branched, 10 - 30 cm in diameter. Externally greyish brown, fine wrinkled longitudinally, nodes swollen bearing rootlets and remained with stem scars, outer bark easily exfoliated, bluish grey. Texture hard and fragile, easily broken, fracture uneven, bark bluish -grey., wood greyish-blue to pale yellowish brown and pith at the center. Root varying in thickness, curved and branched, rootlets slender and flexible. Odour slightly, taste weak.

Identification  : Identification:1.Transverse section: Cork consisting of several rows of cells containing brown contents. Cortex broad having several rows of collenchyma outside, endodermis distinct, stone cells veisible. Phloem relatively narrow phloem fibres more frequent. Xylem broad all the cells in it lignified, vessels single or 2 - 4 grouped, arrange radially, xylem rays broad. In pith cells subrounded or polygonal, stone cells found occasionally. Some parenchymatous cells containing elliptical cystoliths.2.To 2 g of the powder add 20 ml of ethanol, heat under reflux for 1 hour, filter, apply several drops of filtrate to a filter paper, dry it in the air, examine under ultra violet light (365 nm), a purplish red fluorescent color appears. Evaporate the reamininr filtrate to dryness, dissolve the residue in 1 ml of glacial acetic acid, add 1 ml of acetic anhydride and several drops of sulfuric acid. The color of the solution turns gradually from yellow to red, purple, blue the to dark green.3.To 2 g of the powder add 20 ml of chloroform, heat under reflux for 1 hour, filter and concentrate the filtrate to 2 ml and use it as the test solution. Dissolve indigotine CRS and indirubin CRS in chloroform to produce a solution containing 1 mg of indigotine and 0.5 mg of indirubin per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel as the coating substance and benzene-chloroform-acetone (5:4:1) as the mobile phase. Apply separately 10 µl of each of the above two solutions to the plate. After developing and removal of the plate dry it in the air, examine immediately under daylight. The blue spot due to indigotine and purplish red spot due to indirubin I the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference solution respectively.Water: Not more than 12% (Appendix lX H, method 1)Total ash: Not more than 10% (Appendix 1X K)

Processing  : Eliminate foreign matter, wash clean, soften thoroughly, cut into thin slices and dry.

Action  :

Indication  : epidemic febrile diseases with eruption; erysipelas; influenza; epidemic encephalitis

Precautions  :

Dosage  :

Storage  :

Synonymns for Baphicacanthus cusia

Patent Medicines and Medicines with Multiple Ingredients that include Baphicacanthus cusia

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Baphicacanthus cusia in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Jian Yu, Yihan Zhang, Shuju Ning, Qi Ye, Hexin Tan, Ruibing Chen, Qitao Bu, Rui Zhang, Peimin Gong, Xiaoli Ma, Lei Zhang, Daozhi Wei
Molecular cloning and metabolomic characterization of the 5-enolpyruvylshikimate-3-phosphate synthase gene from Baphicacanthus cusia.
BMC Plant Biol.: 2019, 19(1);485
[PubMed:31706293] [WorldCat.org] [DOI] (I e)

Beixian Zhou, Xiaoli Liang, Qitong Feng, Jing Li, Xiping Pan, Peifang Xie, Zhihong Jiang, Zifeng Yang
Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling.
Eur. J. Pharmacol.: 2019, 860;172543
[PubMed:31323223] [WorldCat.org] [DOI] (I p)

Wenjin Lin, Wei Huang, Shuju Ning, Xiaogui Gong, Qi Ye, Daozhi Wei
Comparative transcriptome analyses revealed differential strategies of roots and leaves from methyl jasmonate treatment Baphicacanthus cusia (Nees) Bremek and differentially expressed genes involved in tryptophan biosynthesis.
PLoS ONE: 2019, 14(3);e0212863
[PubMed:30865659] [WorldCat.org] [DOI] (I e)

Meijuan Zeng, Yongjia Zhong, Shijie Cai, Yong Diao
Deciphering the bacterial composition in the rhizosphere of Baphicacanthus cusia (NeeS) Bremek.
Sci Rep: 2018, 8(1);15831
[PubMed:30361644] [WorldCat.org] [DOI] (I e)

Wenjin Lin, Wei Huang, Shuju Ning, Xiaohua Wang, Qi Ye, Daozhi Wei
De novo characterization of the Baphicacanthus cusia(Nees) Bremek transcriptome and analysis of candidate genes involved in indican biosynthesis and metabolism.
PLoS ONE: 2018, 13(7);e0199788
[PubMed:29975733] [WorldCat.org] [DOI] (I e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects