Atractylodes lancea

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Nomenclature

Other Names:

Historical Use of Atractylodes lancea

Atractylodes lancea in Traditional Chinese Medicine

Background

Maocangzhu é²ÔÊõ Zhicangzhu ÖƲÔÊõ Chinese Name (pinyin): Cangzhu

Chinese Name  :

Common Name  :Atractylodes Rhizome

Specific Name  : Rhizoma atracylodis

Scientific Name:
Collection  : The drug is collected in spring and autumn, removed from soil, dried and dashed to discard the fibrous roots.

Description  : Nodular slice or nodular cylindrical, 4 - 9 cm long, 1 - 4 cm in diameter. Externally blackish brown when peeled. Texture lax, fracture scattered with yellow oil cavities. Odour weakly aromatic, taste pungent and bitter.

Identification  : 1.Powder: Brown, needle crystals minute, 5 - 30 µm long, irregularly filled in parenchymatous cells. Fibres mostly in bundles, long fusiform up to 40 µm in diameter with rather thickened lignified walls. Stone cells fairly abundant, sometimes linking up with cork cell, polygonal sub rounded or sub rectangular. 20 - 80 µm in diameter with heavily thickened walls. Inulin frequently visible with radial striations on surface.2.Macerate 1 g of the powder with 5 ml of ether for about 5 minutes and filter. Add several drops of the filtrate to a white porcelain plate. After evaporating the ether, add 1 - 2 drops of a mixture freshly prepared with 2 g of p-dimethylaminobenzaldehyde. 3.3 ml of sulfuric acid and 0.4 ml of water and add 2 drops of ethanol, a rose red colour is produced.3.To 0.5 g of the powder add 2 ml of n-hexane, ultrasonicate for 15 minutes, filter and use the filtrate as the test solution. Prepare a solution of Rhizoma Atractylodis reference drug in the same manner as the reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and petroleum ether (60 - 90ºC)-ethyl acetate (20:1) as the mobile phase. Apply separately to the plate 10 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and spray with 5% solution of p-dimethylaminobenzaldehyde in ethanol containing 10% sulfuric acid, visualized with a current of hot air. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference drug solution and same dirty green principal spot (atractydin) is shown in both chromatogram.Total ash: Not more than 7.0% (Appendix LX K)

Processing  : Rhizoma Atractylodis: Eliminate foreign matter, wash clean, soften thoroughly, cut into thick slices and dry.(stir fried with bran): stir fry the slices as described under the method for stir frying with bran (Appendix ll D) until its outer surface becomes deep yellow. Sub rounded or slated thick slice, scraps not more than 3%.

Action  : To remove damp and invigorate the funtion of the spleen, to dispel wind-cold, and to improve eyesight.

Indication  : epigastric distension and diarrhea; edema, particularly of the legs with lameness; rheumatic arthralgia; common cold; night blindness

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a cool and dry place.

Synonymns for Atractylodes lancea

Patent Medicines and Medicines with Multiple Ingredients that include Atractylodes lancea

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Atractylodes lancea in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Elyza Aiman Azizah Nur, Taichi Ohshiro, Keisuke Kobayashi, Jing Wu, Elly Wahyudin, Huiping Zhang, Fumiaki Hayashi, Hirokazu Kawagishi, Hiroshi Tomoda
Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.
Bioorg. Med. Chem. Lett.: 2020;126997
[PubMed:32035699] [WorldCat.org] [DOI] (I a)

Liqiang Wang, Hui Zhang, Xi Wu, Ziyue Wang, Weiwei Fang, Mei Jiang, Haimei Chen, Linfang Huang, Chang Liu
Phylogenetic relationships of Atractylodes lancea, A. chinensis and A. macrocephala, revealed by complete plastome and nuclear gene sequences.
PLoS ONE: 2020, 15(1);e0227610
[PubMed:31990944] [WorldCat.org] [DOI] (I e)

Ka Woon Karen Chan, Hau Yin Chung, Wing Shing Ho
Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro.
Molecules: 2020, 25(1);
[PubMed:31947901] [WorldCat.org] [DOI] (I e)

Peifeng Zhang, Fang Zheng, Lei Chen, Xiaofang Lu, Wei Tian
CIP elicitors on the defense response of A. macrocephala and its related gene expression analysis.
J. Plant Physiol.: 2020, 245;153107
[PubMed:31881440] [WorldCat.org] [DOI] (I p)

Da Qing Yu, Xiao Jing Han, Ting Yu Shan, Rui Xu, Jin Hu, Wang Xing Cheng, Liang Ping Zha, Hua Sheng Peng
Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts.
Molecules: 2019, 24(24);
[PubMed:31842368] [WorldCat.org] [DOI] (I e)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects