Atractylodes chinensis

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Nomenclature

Other Names:

Historical Use of Atractylodes chinensis

Atractylodes chinensis in Traditional Chinese Medicine

Background

Maocangzhu é²ÔÊõ Zhicangzhu ÖƲÔÊõ Chinese Name (pinyin): Cangzhu

Chinese Name  :

Common Name  :Atractylodes Rhizome

Specific Name  : Rhizoma atracylodis

Scientific Name:
Collection  : The drug is collected in spring and autumn, removed from soil, dried and dashed to discard the fibrous roots.

Description  : Nodular slice or nodular cylindrical, 4 - 9 cm long, 1 - 4 cm in diameter. Externally blackish brown when peeled. Texture lax, fracture scattered with yellow oil cavities. Odour weakly aromatic, taste pungent and bitter.

Identification  : 1.Powder: Brown, needle crystals minute, 5 - 30 µm long, irregularly filled in parenchymatous cells. Fibres mostly in bundles, long fusiform up to 40 µm in diameter with rather thickened lignified walls. Stone cells fairly abundant, sometimes linking up with cork cell, polygonal sub rounded or sub rectangular. 20 - 80 µm in diameter with heavily thickened walls. Inulin frequently visible with radial striations on surface.2.Macerate 1 g of the powder with 5 ml of ether for about 5 minutes and filter. Add several drops of the filtrate to a white porcelain plate. After evaporating the ether, add 1 - 2 drops of a mixture freshly prepared with 2 g of p-dimethylaminobenzaldehyde. 3.3 ml of sulfuric acid and 0.4 ml of water and add 2 drops of ethanol, a rose red colour is produced.3.To 0.5 g of the powder add 2 ml of n-hexane, ultrasonicate for 15 minutes, filter and use the filtrate as the test solution. Prepare a solution of Rhizoma Atractylodis reference drug in the same manner as the reference drug solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and petroleum ether (60 - 90ºC)-ethyl acetate (20:1) as the mobile phase. Apply separately to the plate 10 µl of each of the two solutions. After developing and removal of the plate, dry it in the air and spray with 5% solution of p-dimethylaminobenzaldehyde in ethanol containing 10% sulfuric acid, visualized with a current of hot air. The spots in the chromatogram obtained with the test solution correspond in position and colour to the spot in the chromatogram obtained with the reference drug solution and same dirty green principal spot (atractydin) is shown in both chromatogram.Total ash: Not more than 7.0% (Appendix LX K)

Processing  : Rhizoma Atractylodis: Eliminate foreign matter, wash clean, soften thoroughly, cut into thick slices and dry.(stir fried with bran): stir fry the slices as described under the method for stir frying with bran (Appendix ll D) until its outer surface becomes deep yellow. Sub rounded or slated thick slice, scraps not more than 3%.

Action  : To remove damp and invigorate the funtion of the spleen, to dispel wind-cold, and to improve eyesight.

Indication  : epigastric distension and diarrhea; edema, particularly of the legs with lameness; rheumatic arthralgia; common cold; night blindness

Precautions  :

Dosage  : 3 to 9 g.

Storage  : Preserve in a cool and dry place.

Synonymns for Atractylodes chinensis

Patent Medicines and Medicines with Multiple Ingredients that include Atractylodes chinensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Atractylodes chinensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Liqiang Wang, Hui Zhang, Xi Wu, Ziyue Wang, Weiwei Fang, Mei Jiang, Haimei Chen, Linfang Huang, Chang Liu
Phylogenetic relationships of Atractylodes lancea, A. chinensis and A. macrocephala, revealed by complete plastome and nuclear gene sequences.
PLoS ONE: 2020, 15(1);e0227610
[PubMed:31990944] [WorldCat.org] [DOI] (I e)

Yang Cheng, Tianyang Chen, Xueli Yang, Jianhua Xue, Jianjie Chen
Atractylon induces apoptosis and suppresses metastasis in hepatic cancer cells and inhibits growth in vivo.
Cancer Manag Res: 2019, 11;5883-5894
[PubMed:31388314] [WorldCat.org] [DOI] (P e)

Dan Zhuang, Jing Qin, Hui-Yang Wang, Yi Zhang, Chun-Yao Liu, Qing-Qing Ding, Guang-Ping Lv
Oligosaccharide-based quality evaluation of Atractylodis rhizome and a strategy for simplifying its quality control.
BMC Chem: 2019, 13(1);92
[PubMed:31384839] [WorldCat.org] [DOI] (I e)

Yu Feng, Yan Chen, Binrui Yang, Qingping Lan, Tao Wang, Guozhen Cui, Zhitao Ren, I Cheong Choi, George Pak-Heng Leung, Fenggen Yan, Dacan Chen, Hon Ho Yu, Simon Ming Yuen Lee
Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat.
Biomed Res Int: 2019, 2019;7465272
[PubMed:31355279] [WorldCat.org] [DOI] (I e)

Toshinari Ishii, Tetsuya Okuyama, Nao Noguchi, Yuto Nishidono, Tadayoshi Okumura, Masaki Kaibori, Ken Tanaka, Susumu Terabayashi, Yukinobu Ikeya, Mikio Nishizawa
Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice.
J Nat Med: 2020, 74(1);51-64
[PubMed:31270736] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects