Aristolochia manshuriensis

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Nomenclature

Other Names:

Historical Use of Aristolochia manshuriensis

Aristolochia manshuriensis in Traditional Chinese Medicine

Background

Chinese Name (pinyin): Guanmutong

Chinese Name  :

Common Name  :Manchurian Dutchmanspipe Stem

Specific Name  : Caulis aristolochiae manshuriensis

Scientific Name:
Collection  : The drug is collected in autumn and winter, remove from coarse bark and dried in the sun.

Description  : Long cylindrical, slightly twisted, 1-2m long, 1-6cm in diameter. Externally greyish-yellow or brownish yellow with swallow longitudinal grooves and adhering remains of brown patches of coarse bark. Nodes slightly swollen with a branch scar. Hard and light texture, uneasily broken, fracture yellow or pale yellow, bark narrow, wood broad and exhibiting vessels arranged in many rings, rays radial, pith indistinct. The drug giving off a smell like camphor on rubbing the remains of coarse bark. Odor slight and taste bitter.

Identification  : 1. Powder: pale yellow, most fiber tracheids in bundles, long fusiform, 11-20µm in diameter, the walls distinctly bordered pitted, the pit apertures oblique slit or crossed. Septate fibres 21-24 µm in diameter with distinct oblique pits. Stone cells infrequent, subsquare or subpolygonal with relatively thick walls. Clusters of calciums oxalate up to 40µmºººº in diameter. Bordered pitted vessels large up to 328 µm in diameter, mostly broken, bordered pits sorrounded, closely arranged, bordered pitted tracheids infrequent.3. Heat under reflux about 1g of the powder with 20ml of 70% ethanol for 15 minutes, cool and filter. Spot the filtrate on the filter paper, dry it in the air, a sky-blue fluorescence is produced under ultra violet light (365nm), add 1 drop of dilute hydrochloric acid to the spot and dry, a yellowish-green fluorescence is shown, which turns to sky-blue fluorescence again on exposing to ammonia vapour.4. Heat under reflux 1g of the powder with 50ml of ethanol on a water bath for 1 hour and filter. Evaporate the filtrate to dryness and dissolve the residue in 1ml of ethanol as the test solution. Prepare a solution of Caulis Aristolochiae Manshuriensis reference drug in the same manner as the reference drug solution. Dissolve aristolochic acid CRS in ethanol to produce a solution containing 0.5mg per ml as the reference solution. Carry out the method for thin layer chromatography (Appendix Vl B), using silica gel G as the coating substance and upper layer of toluene-ethyl acetate-water-formic acid (20:10:1:1) as the mobile phase. Apply in strips separately to the plate 3µl of the three solutions. After developing and removal of the plate, dry it in the air and examine under the day-light and ultra violet light (365nm) respectively. The strips in the chromatogram obtained with the test solution correspond in the position and colour to the strips in the chromatogram obtained with the reference drug solution and the reference solution repectively.Extractives: Carry out the cold extraction method as described under the determination of water-soluble extractivres (Appendix lX K) not less that 16.0%

Processing  : clean wash, soften thoroughly, cut into thin slices and dry in the sun.

Action  : To remove heat from the heart, to relieve dysuria and promote diuresis, to stimulate menstrual discharge, and to promote the flow of milk.

Indication  : ulcers in the mouth and on the tongue accompanied by fidgets and dark urine; edema, painful difficult urination; excessive leukorrhea; amenorrhea; lack of lactation; acute arthritis due to damp heat

Precautions  : Used with caution in pregnancy.

Dosage  : 3 to 6 g.

Storage  : Preserve in a ventilated dry place.

Synonymns for Aristolochia manshuriensis

Patent Medicines and Medicines with Multiple Ingredients that include Aristolochia manshuriensis

Pharmaceutical Information

Chemical Constituents

Evidence or the Use of Aristolochia manshuriensis in the Treatment of Epilepesy

Basic Science

Animal Studies

Cohort, Case-Control and Non-Randomized Trials

Randomized Controlled Trials

Meta-Analysis

1st Five Results: pubmed search

Lianmei Wang, Chunying Li, Jingzhuo Tian, Jing Liu, Yong Zhao, Yan Yi, Yushi Zhang, Jiayin Han, Chen Pan, Suyan Liu, Nuo Deng, Zhong Xian, Guiqin Li, Xin Zhang, Aihua Liang
##Title##
Pharm Biol: 2020, 58(1);98-106
[PubMed:31957525] [WorldCat.org] [DOI] (I p)

Wenjuan Duan, Yue Li, Hongjing Dong, Guohong Yang, Wei Wang, Xiao Wang
Isolation and purification of six aristolochic acids with similar structures from Aristolochia manshuriensis Kom stems by pH-zone-refining counter-current chromatography.
J Chromatogr A: 2019;460657
[PubMed:31685246] [WorldCat.org] [DOI] (I a)

Yuan Cui, Jiayin Han, Juan Ren, Huiming Chen, Baoliang Xu, Naining Song, Haishan Li, Aihua Liang, Guolin Shen
Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, β-oxidation of fatty acids and the TCA cycle in male mice.
Toxicol. Appl. Pharmacol.: 2019, 373;26-38
[PubMed:31009690] [WorldCat.org] [DOI] (I p)

Lianmei Wang, Xiaoshuang Ding, Chunying Li, Yong Zhao, Changan Yu, Yan Yi, Yushi Zhang, Yue Gao, Chen Pan, Suyan Liu, Jiayin Han, Jingzhuo Tian, Jing Liu, Nuo Deng, Guiqin Li, Aihua Liang
Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.
J Ethnopharmacol: 2018, 225;81-89
[PubMed:30008395] [WorldCat.org] [DOI] (I p)

O V Nakonechnaya, A V Kalachev
Pollen ultrastructure in Aristolochia manshuriensis and A. contorta (Aristolochiaceae).
Protoplasma: 2018, 255(5);1309-1316
[PubMed:29511834] [WorldCat.org] [DOI] (I p)

Safety

Allergies

Side Effect and Warnings

Pregnancy and Breastfeeding

Adverse Effects